Physico-Chemical Properties of Low Density Lipoproteins in Normolipidemic Asian Indian Men

Abate, N.; Garg, Abhimanyu; Enas, E. A.

doi:10.1055/s-2007-979971

Cited by 10 publications

(4 citation statements)

References 21 publications

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“…In a recent study, prevalence of small, dense, LDL of 12.5%–14.2% was reported in migrant Indians, as compared with 15.7%–17.2% in rural Indians 21. In another study comparing normolipidemic migrant, Asian Indians and Caucasians, a 15% frequency of pattern B was reported in Indians as compared with 41% in Caucasians 22. Genetic makeup and environment factors are important determinants of sdLDL.…”

Section: Discussionmentioning

confidence: 95%

LDL particle heterogeneity, and its association with other established cardiovascular risk factors in a young Indian industrial population

et al. 2012

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Objective Low density lipoprotein (LDL) particles are heterogeneous in terms of size, density, chemical composition and electric charge with certain particle of LDL being more atherogenic than the others. The present study aimed to look at the LDL particle heterogeneity, particle size and association with other cardiovascular disease (CVD) risk factors in young Indian industrial population. Methodology 600 employees of an industry of Delhi, aged 20-39 years were selected for the study. Data on demographics, individual characteristics associated with major risk factors of CVD, past medical history, clinical and anthropometric profile was collected. Fasting glucose, lipid profile, apolipoprotein (A1, B, and E), lipoprotein (a), high sensitive C-reactive protein (hsCRP) and insulin were estimated. LDL particle size was determined in ethylenediamminetetraacetate (EDTA) plasma by 3% polyacrylamide gel electrophoresis. Result We found a prevalence of small dense LDL phenotype (LDL size ≤ 26.3) in 27.4% of males and 24.0% of females. The mean waist circumference, blood pressure, triglycerides (TAG), cholesterol, hsCRP, apolipoprotein (A1, B and E) and insulin were higher in males whereas mean high density lipoprotein was higher in females. Females also had a significantly higher mean LDL particle diameter as compared to males. Conclusion TAG, physical activity and lipoprotein (a) correlated with small dense LDL in this young Indian population.

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Section: Discussionmentioning

confidence: 95%

LDL particle heterogeneity, and its association with other established cardiovascular risk factors in a young Indian industrial population

et al. 2012

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“…A few earlier studies [13,14] compared small dense LDL distribution in migrant Indians and Europeans, but they showed contradictory results with one showing a higher frequency of small dense LDL in Indians [13] while the other reporting Indians to have larger LDL size [14]. However, both these studies merely looked at the frequency of LDL sub fractions in Indians and not specifically to its association with CAD.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Small Dense Low Density Lipoprotein and Coronary Artery Disease in North Indian Patients

et al. 2016

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Pathogenesis of coronary artery disease (CAD) is multi-factorial and several conventional risk factors have been ascribed; LDL-C being one of the important risk factor. However Indian population studies with established CAD often show LDL levels within normal range in patients with proven CAD. We hypothesized that Small dense low density lipoprotein (sdLDL) being more atherogenic might correlate more strongly to the occurrence and severity of CAD. The aim of the study was to evaluate the association between serum small dense LDL level and angiographically documented coronary artery disease. This is a cross sectional case control study in which sdLDL were measured in 126 patients with CAD and in 64 patients without CAD. Total cholesterol, HDL Cholesterol, LDL cholesterol and triglycerides were measured by standard methods along with other traditional risk factors. Direct quantitative measurement of sdLDL was done by enzymatic analysis. Mean sdLDL level was higher in patients with coronary stenosis than patients without coronary stenosis (16.3 ± 6.8 vs. 10.1 ± 5.7 mg/dL respectively, ( < 0.001). There was significant correlation between mean sdLDL and severity of CAD as assessed by syntax score with mean sdLDL level in low, intermediate and high syntax score being 15.0 ± 5.8, 20.1 ± 6.7 and 22.7 ± 7.3 mg/dL respectively ( value <0.001). A cut off value of 10.02 mg/dL was associated with presence of CAD (95 % CI 0.82-0.93, < 0.001) using ROC curve. In conclusion Indian patients with established CAD have higher sdLDL levels compared to individuals without CAD despite having comparable LDL levels.

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“…An elevation in the levels of cholesterol among higher SES groups indicated greater risk of CHD. Previous Indian research suggests that people with a cholesterol level greater than 300 mg% have four times the risk of CHD than people with less than 200 mg% 20 . Recent reports indicate that, Indian populations with a mean cholesterol level of 150 mg% or less have little risk of CHD 21,22 .…”

Section: Discussionmentioning

confidence: 99%

Socioeconomic status and the prevalence of coronary heart disease risk factors

Reddy

Rao

Reddy

2002

Asia Pac J Clin Nutr

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South Asian countries have a high prevalence of coronary heart disease (CHD) in line with their economic development. India, in particular, has a high burden of CHD. Hence, the aim of the present study was to assess the prevalence of CHD risk factors in a semiurban population of Andhra Pradesh, India, in different socioeconomic status (SES) groups. Information was collected on socioeconomic status, physical activity, cigarette smoking, body mass, blood pressure (BP) and serum lipid profiles among a healthy sample of 440 men and 210 women with an age range of 20-70 years. Mean levels of serum cholesterol (SC), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC) and skinfold ratio were found to be higher among women, whereas triglycerides (TG), systolic BP and diastolic BP were higher in men. No statistically significant differences in body mass index (BMI) or pulse rate were observed between the sexes. In men, a significant positive rank correlation (rho = P < 0.05) was observed between SES and SC, TG, systolic and diastolic BP, pulse rate and BMI, but in women, the same trend was found only with SC, TG, skinfold ratio and age. The prevalence (age standardized to the world population of Segi, 95% CI) of obesity was 14.37% (11.06-17.68), hypertension 13.13% (9.11-17.15), hypercholesterolemia 18.56% (13.88-23.24), hypertriglyceridemia 45.98% (36.47-55.49) and low HDLC 31.01% (24.25-37.77). In both sexes, the prevalence of hypercholesterolemia, hypertriglyceridemia and sedentary life style increased among higher SES groups (P < 0.05). Also, an increase in the level of social class was positively associated with mean levels of serum cholesterol and triglycerides in both men and women. The results demonstrate that higher SES groups have greater prevalence of CHD risk factors than lower SES groups. Preventive measures are required to reduce the risk factors among higher SES groups.

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Physico-Chemical Properties of Low Density Lipoproteins in Normolipidemic Asian Indian Men

Cited by 10 publications

References 21 publications

LDL particle heterogeneity, and its association with other established cardiovascular risk factors in a young Indian industrial population

LDL particle heterogeneity, and its association with other established cardiovascular risk factors in a young Indian industrial population

The Association Between Small Dense Low Density Lipoprotein and Coronary Artery Disease in North Indian Patients

Socioeconomic status and the prevalence of coronary heart disease risk factors

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