Physicochemical and Antibacterial Characterization of Nanofibrous Wound Dressing from Silk Fibroin-polyvinyl Alcohol- Elaeagnus Angustifolia Extract

Nourmohammadi, Jhamak; Hadidi, Meghdad; Nazarpak, Masoumeh Haghbin; Mansouri, Mona; Hasannasab, Maede

doi:10.1007/s12221-020-9428-4

Cited by 24 publications

(24 citation statements)

References 41 publications

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“…Polyvinyl alcohol (PVA) is widely used in biomedical applications due to its excellent biodegradability, biocompatibility, chemical resistance, and good fiber-forming properties [ 7 ]. Great attention has been directed towards hybrid polymer materials’ electrospinning with the utilization of some transition metal nanoparticles, e.g., Au, Pt, and Ag in the PVA nanofiber [ 8 ]. Among them, Ag is the most attractive metal because of its low human toxicity and strong activity against a wide spectrum of bacteria.…”

Section: Introductionmentioning

confidence: 99%

Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities

et al. 2022

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Healthcare textiles are gaining great attention in the textile industry. Electrospun nanofibers are considered the golden soldiers due to their strength, flexibility, and eco-friendly properties. The present study aimed to evaluate the potency of polyvinyl alcohol (PVA) nanofibers loaded with newly biosynthesized silver nanoparticles (Ag-NPs) as a wound healing dressing. Chocolate-band snail (Eobania vermiculata) mucus (which is part of the Mollusca defense system) was used as a novel reducing and stabilizing agent. Data indicated the effectiveness of Eobania vermiculata’s mucus in silver nanoparticle synthesis after a 24 h incubation time. The biosynthesized AgNPs-SM showed a 13.15 nm particle size, −22.5 mV ζ potential, and 0.37 PDI, which proved the stability of the synthesized nanoparticles. Eobania vermiculata mucus and AgNPs-SM showed potent antibacterial activity, especially against Pseudomonas aeruginosa. The electrospinning technique was applied in the fabrication of PVA/AgNPs-SM nanofibers, which were homogenous with a fine diameter of about 100–170 nm and showed a significantly high antimicrobial activity. In vitro and in vivo studies revealed that PVA/AgNPs-SM nanofibers were safe and efficiently enhanced the wound healing process (typical histological picture of the proliferative phase with compact and well aligned collagen fibers in the dermal tissue after 12 days) together with bacterial growth inhibition in the infected skin area.

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Section: Introductionmentioning

confidence: 99%

Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities

et al. 2022

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“…The antimicrobial polymeric electrospun fibers seen in Table 1 are used as wound dressings. [ 112–128 ] The physical and mechanical properties of diverse electrospun fiber are seen in Table 2 . [ 129–140 ]…”

Section: Antimicrobial Polymeric Nanofibermentioning

confidence: 99%

“…The antimicrobial polymeric electrospun fibers seen in Table 1 are used as wound dressings. [112][113][114][115][116][117][118][119][120][121][122][123][124][125][126][127][128] The physical and mechanical properties of diverse electrospun fiber are seen in Table 2. [129][130][131][132][133][134][135][136][137][138][139][140] Figure 9A illustrates a depiction of a polymeric antibacterial dressing intended to serve as a physical shield of the wound from microbial invasion while promoting fibroblast migration and differentiation.…”

Section: Alginate (Alg)mentioning

confidence: 99%

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Antimicrobial Synthetic and Natural Polymeric Nanofibers as Wound Dressing: A Review

et al. 2022

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Since ancient times, wound dressings have experienced many significant improvements. Evolution began using natural materials to merely cover wounds and advanced to used innovative techniques that can be customized to perform different impressive functions. Recent wound dressings, which are made of electrospun polymers, contain different active compounds, such as antimicrobial agents, that aid in wound healing and prevent dehydration and infection. The mentioned issues may influence the healing process, leading even to serious health risks for the patients. As a result, scientists are now working on novel wound bandages with improved antimicrobial properties. Electrospun polymeric nanofibers, because of their structural similarities to normal skin's extracellular matrix (ECM), bactericidal activity, and appropriateness to distribute bioactive molecules to the wound location, are regarded as good resources for enhancing skin regeneration and controlling wound infection. Herein, the latest findings on approaches for producing antimicrobial polymeric nanofibers using electrospinning and related processes are discussed. Recent advances in antibacterial biopolymeric nanofibers incorporating antimicrobial nanoparticles (silver, zinc oxide, copper oxide, etc.) are discussed. This review paper may raise significant issues, encourage additional research, and offer important insight into the potential area of antibacterial polymeric fibers.

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“…In recent decade, increase of drug effectiveness and decrease of side effects of high concentration drugs scattered on body cells have drawn lots of attention. Hence, local drug delivery, targeted drug delivery, drug release rate control, enhanced cell penetration and internalization have been the subject of numerous researches [1][2][3][4][5][6][7][8][9][10][11]. Diverse nanocarriers were used to achieve the mentioned goal such as metalorganic frameworks (MOFs) as the most tunable nanocarriers with tailored size of pores and functional groups and the uniform structure [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Single-step Synthesis and Characterization of Zr-MOF onto Wool Fabric: Preparation of Antibacterial Wound Dressing with High Absorption Capacity

et al. 2021

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Improvement of curative herbal extracts effectiveness through novel drug delivery systems is a field of study for the researches nowadays. Zirconium-based metal-organic frameworks (Zr-MOFs) are one of the most capable porous nanocarriers that need a biocompatible template to be used in biomedical applications. In this work, Zr-MOF was synthesized into the wool fabric through in-situ one-pot method with different molar ratios. The final fabrics were characterized thoroughly using various techniques and the effect of components on monodispersity and nucleation tendency of Zr-MOF onto the surface of wool were explained. The resultant fabric stablished absolute wash durability, increased air-permeability up to twice and reasonable hydrophilicity. Tensile strength and young modulus decreased 30 and 1244 % and strain increased 66 %. Salvia Officinalis (SO) and Calendula Officinalis (CO) extracts were loaded onto the modified fabrics with 1154 and 1842 % increased absorption capacity. The release profiles showed domination of diffusion mechanism. The wool-MOF-SO and CO displayed both 100 % antibacterial activity against Escherichia coli and 60.95 and 64.64 % against Staphylococcus aureus because of diverse antibacterial components. Calendula Officinalis proved biocompatibility with human skin however Salvia Officinalis exhibited high toxicity.

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Physicochemical and Antibacterial Characterization of Nanofibrous Wound Dressing from Silk Fibroin-polyvinyl Alcohol- Elaeagnus Angustifolia Extract

Cited by 24 publications

References 41 publications

Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities

Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities

Antimicrobial Synthetic and Natural Polymeric Nanofibers as Wound Dressing: A Review

Single-step Synthesis and Characterization of Zr-MOF onto Wool Fabric: Preparation of Antibacterial Wound Dressing with High Absorption Capacity

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