Physicochemical and mechanical properties of CO2 laser-modified biodegradable polymers for medical applications

Kobielarz, Magdalena; Gazińska, Małgorzata; Tomanik, Magdalena; Stępak, Bogusz; Szustakiewicz, Konrad; Filipiak, Jarosław; Antończak, Arkadiusz J.; Pezowicz, Celina

doi:10.1016/j.polymdegradstab.2019.05.010

Cited by 13 publications

(21 citation statements)

References 42 publications

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“…However, due to the action of the laser beam on the polymer material, photochemical degradation of the material may occur [ 24 , 25 ], significantly affecting the material properties of the polymer. Only a few studies have focused on assessing the impact of irradiation of biodegradable polymers with a CO 2 laser on their mechanical [ 15 , 22 ] or physicochemical properties [ 16 , 32 ]. The use of a low value of accumulated fluence strengthens and stiffens the material, which is visible in uniaxial tensile tests [ 22 ] and under hydrolytic degradation [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…The tests were carried out using PLLA (L210S, Evonik Industries AG, Essen, Germany), which underwent the process of formation described in detail in previous studies by our group [ 21 , 22 ]. Briefly, thin films of the material were produced by heating the granulate to a temperature of 200 °C, followed by melt processing.…”

Section: Methodsmentioning

confidence: 99%

“…One way to structure the surfaces of biodegradable polymers is to irradiate the materials with a CO 2 laser beam [ 16 , 17 , 18 , 19 , 20 , 21 ]. It is known that a CO 2 laser surface irradiation causes formation of nano- and microstructures on the surfaces of the treated materials [ 10 , 21 ] which can alter their mechanical characteristics [ 21 , 22 ]. However, the use of a laser treatment process, due to the associated thermal effects, may adversely affect the material and change its properties [ 16 , 21 , 23 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

“…Performing further research for such a large number of cases/fluences would be redundant, as certain regularities were observed for specific ranges of fluence. Therefore, we limited our considerations to three characteristic surface fluences: 24, 48, and 71 J/cm 2 [ 21 , 22 ]. The first fluence (24 J/cm 2 ) is the maximum value of the energy density at which neither surface layer melting nor ablation was observed.…”

Section: Introductionmentioning

confidence: 99%

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Laser Texturing as a Way of Influencing the Micromechanical and Biological Properties of the Poly(L-Lactide) Surface

et al. 2020

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Laser-based technologies are extensively used for polymer surface patterning and/or texturing. Different micro- and nanostructures can be obtained thanks to a wide range of laser types and beam parameters. Cell behavior on various types of materials is an extensively investigated phenomenon in biomedical applications. Polymer topography such as height, diameter, and spacing of the patterning will cause different cell responses, which can also vary depending on the utilized cell types. Structurization can highly improve the biological performance of the material without any need for chemical modification. The aim of the study was to evaluate the effect of CO2 laser irradiation of poly(L-lactide) (PLLA) thin films on the surface microhardness, roughness, wettability, and cytocompatibility. The conducted testing showed that CO2 laser texturing of PLLA provides the ability to adjust the structural and physical properties of the PLLA surface to the requirements of the cells despite significant changes in the mechanical properties of the laser-treated surface polymer.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Laser Texturing as a Way of Influencing the Micromechanical and Biological Properties of the Poly(L-Lactide) Surface

et al. 2020

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“…The problem of the biocompatibility of materials is a matter of great importance in medical materials science. To increase the biocompatibility of implants, ______________________________ additional coatings [7], [11] and surface modifications [10], [14] are applied to their surface. There has been a recent growth in interest regarding calcium-phosphate (СаР) and hydroxyapatite Ca 10 (PO 4 ) 6 (OH) 2 (HA) coatings, which significantly increase the adhesive strength of implants with bone tissue [5], [19], [22].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the adhesion properties of calcium-phosphate coating to titanium substrate with regards to the parameters of high-frequency magnetron sputtering

Kenzhegulov

Mamaeva

Panichkin

et al. 2020

Acta Bioeng Biomech

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Purpose: The main goal of the work was to find the interconnection between the high-frequency magnetron sputtering parameters and the adhesion properties of CaP coatings formed on the surface of titanium substrate. Methods: Calcium-phosphate coatings, similar in composition to hydroxyapatite, were generated by high-frequency magnetron sputtering on titanium substrate at different values of high-frequency specific power over times of one and two hours. Afterwards, the generated coatings were studied using the method of X-ray phase analysis, and sclerometric tests (scratch test) were carried out. The adhesion strength of the deposited coatings was tested for different coating thicknesses from 0.45 to 1.1 × 10–3 mm. Results: According to the results of sclerometry, it was found that with an increase in the high-frequency specific power of plasma to 3.15 W/cm2, the adhesion strength of the calcium-phosphate coating also increases. For all the coatings, the critical loads at which the coating completely exfoliated from the substrate were determined. Conclusions: According to the research results, the most optimal conditions for obtaining high-adhesive calcium-phosphate coatings were determined.

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3D Printing in Biocatalysis and Biosensing: From General Concepts to Practical Applications

Nyenhuis,

Heuer,

Bahnemann

2024

Chemistry An Asian Journal

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3D printing has matured into a versatile technique that offers researchers many different printing methods and materials with varying properties. Nowadays, 3D printing is deployed within a myriad of different applications, ranging from chemistry to biotechnology – including bioanalytics, biocatalysis or biosensing. Due to its inherent design flexibility (which enables rapid prototyping) and ease of use, 3D printing is facilitating the relatively quick and easy creation of new devices with unprecedented functions. This review article describes how 3D printing can be employed for research in the fields of biochemistry and biotechnology, and specifically for biocatalysis and biosensor applications. We survey different relevant 3D printing techniques, as well as the surface activation and functionalization of 3D‐printed materials. Finally, we show how 3D printing is used for the fabrication of reaction ware and enzymatic assays in biocatalysis research, as well as for the generation of biosensors using aptamers, antibodies, and enzymes as recognition elements.

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Physicochemical and mechanical properties of CO2 laser-modified biodegradable polymers for medical applications

Cited by 13 publications

References 42 publications

Laser Texturing as a Way of Influencing the Micromechanical and Biological Properties of the Poly(L-Lactide) Surface

Laser Texturing as a Way of Influencing the Micromechanical and Biological Properties of the Poly(L-Lactide) Surface

Investigation of the adhesion properties of calcium-phosphate coating to titanium substrate with regards to the parameters of high-frequency magnetron sputtering

3D Printing in Biocatalysis and Biosensing: From General Concepts to Practical Applications

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