Physicochemical Aspects of Fluoride-Apatite Systems Relevant to the Study of Dental Caries

Moreno, E.C.; Kresak, M.; Zahradnik, R.T.

doi:10.1159/000260299

Cited by 259 publications

(131 citation statements)

References 7 publications

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“…Fluoride at concentrations below 105.3 ÌM reportedly reduced the rate of crystallization in the initial stage [Meyer and Nancollas, 1972], whereas higher concentrations enhanced the rate [Amjad and Nancollas, 1979]. Other reports indicate an increase in the rate of apatite crystal growth with fluoride concentrations as low as 5.3 ÌM [Moreno et al, 1977]. In the present study, fluoride at 40 ÌM significantly reduced the mineral induction time by dentin matrix.…”

Section: Discussionsupporting

confidence: 45%

In vitro Study of Remineralization of Dentin: Effects of Ions on Mineral Induction by Decalcified Dentin Matrix

et al. 2003

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We examined the effects of various ions on the mineralization of dentin matrix in vitro. Demineralized dentin matrix was incubated in a metastable calcium phosphate solution with or without silicate, fluoride, calcium, phosphate, magnesium or silver. Insoluble dentin matrix induced mineral formation after incubation for 10.2 h in the metastable solution without added ions. Silicate at 5 µM and fluoride at 40 µM significantly reduced the mineral induction time. At least 200 µM calcium or 100 µM phosphate was required to promote mineral induction. Conversely, magnesium and silver concentrations as low as 10 and 2 µM inhibited mineral induction. The mineral induced by each sample after incubation for 24 h was identified by its X-ray diffraction pattern as apatite. We concluded that silicate is a stronger inducer of remineralization of dentin matrix than fluoride, calcium or phosphate, and that magnesium and silver inhibit the induction of remineralization of dentin matrix.

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Section: Discussionsupporting

confidence: 45%

In vitro Study of Remineralization of Dentin: Effects of Ions on Mineral Induction by Decalcified Dentin Matrix

et al. 2003

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“…Fluoride ions release occurs via fluoride ion diffusion from the bulk of the OH group radius (1.4 A o ); the OH groups of hydroxyapatite crystals of enamel can be replaced by fluoride ions to form fluorapatite [15][16][17][18] . Due to lower solubility and lower crystal energy of fluorapatite in comparison to hydroxyapatite, enamel which uptakes fluoride at hydroxyl sites is more caries resistant and more durable against bacterial acid attacks 18,19) . Fluoride enhances the crystallinity of the hydroxyapatite crystals and affects the composition of bacterial plaque, which may alter carbohydrate metabolism in it.…”

Section: Discussionmentioning

confidence: 99%

Effects of incorporation of nano-fluorapatite particles on microhardness, fluoride releasing properties, and biocompatibility of a conventional glass ionomer cement (GIC)

Moshaverinia

Borzabadi‐Farahani

Sameni

et al. 2016

Dental Materials Journal

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Present study evaluated effects of addition of Nanoparticles fluorapatite (Nano-FA) on microhardness and fluoride release of a Glass Ionomer Cement (GIC, Fuji IX GP Fast). Forty-eight specimens prepared, divided equally into 4 groups (2 with Nano-FA); after 24 h and one week Vickers microhardness (HV) was measured. Nano-FA specimens were made from addition of nano-FA to Fuji IX powder (glass powder/Nano-FA ratio=20:1 wt/wt, 3.6:1 P/L ratio). At 24 h, mean (95% CI) HV for GIC and Nano-FA GIC were 40.

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“…Fluoride is a well-known cariostatic agent which is responsible for a major reduction in the prevalence of dental caries (2,12). The principal cariostatic effect of fluoride is considered to depend on its incorporation into the enamel crystal structure with a resulting decrease in acid susceptibility of the tooth mineral (14). Fluoride also has inhibitory effects on numerous enzymes (17) and on the fermentative activities and viability of oral microbes, including S. mutans (for reviews, see references 7, 11, 13, and 16).…”

mentioning

confidence: 99%

Role of the cell membrane in pH-dependent fluoride inhibition of glucose uptake by Streptococcus mutans

Germaine¹,

Tellefson²

1986

Antimicrob Agents Chemother

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The effect of pH on the fluoride sensitivity of glucose uptake by whole cells and glucose transport by permeabilized cells of Streptococcus mutans was compared. Whole cells exhibited a marked pH-dependent sensitivity to fluoride over the pH range 7.0 to 5.0. As the pH was decreased, fluoride sensitivity increased. In contrast, no significant effect of pH on the fluoride sensitivity of glucose transport (e.g., phosphorylation) by permeabilized cells energized with 2-phosphoglycerate was noted. The relative effect of pH on the fluoride sensitivity of whole cell glucose uptake and fermentation was similar. These data are consistent with the notion that the cell membrane is impermeable to the fluoride anion and that intracellular accumulation of fluoride depends on translocation of hydrogen fluoride across the membrane.Streptococcus mutans is a colonizer of the human tooth surface and is associated with the development of dental caries in humans (5,6,15). This organism is noted for its aciduric, as well as its acidogenic, properties relative to those of other common plaque microorganisms (8,9,15). Development of dental caries is thought to depend on the acid demineralization of tooth enamel as a direct result of the acidic fermentative activities of S. mutans and other plaque microbes (15). Plaque pH varies from near neutral values in the resting state (no fermentable substrates available) to well below pH 5 during periods of exposure to fermentable substrates (15). Fluoride is a well-known cariostatic agent which is responsible for a major reduction in the prevalence of dental caries (2, 12). The principal cariostatic effect of fluoride is considered to depend on its incorporation into the enamel crystal structure with a resulting decrease in acid susceptibility of the tooth mineral (14). Fluoride also has inhibitory effects on numerous enzymes (17) and on the fermentative activities and viability of oral microbes, including S. mutans (for reviews, see references 7, 11, 13, and 16). The fluoride sensitivity of S. mutans sugar fermentation and growth is generally increased as the pH is decreased (1,7,11,16). It has been suggested that the pH-dependent nature of fluoride sensitivity is based on the passive permeability of the cell membrane to HF and impermeability to fluoride anion (16). As the pH of the environment is decreased, the absolute concentration of HF is increased (pK, -3.45) and the pH difference across the cell membrane promotes accumulation of fluoride into the more alkaline cell cytoplasm. This model is supported by the observation that the intracellular accumulation of fluoride increases with the magnitude of the pH difference across the cell membrane of S. mutans (16). In light of these observations, we chose to investigate the role of the cell membrane in the pH sensitivity of fluoride inhibition of glucose uptake and transport by S. mutans over the pH range commonly encountered in plaque. If the model described above is correct, whole cell glucose uptake, but not glucose transport by permeabilized ...

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Physicochemical Aspects of Fluoride-Apatite Systems Relevant to the Study of Dental Caries

Cited by 259 publications

References 7 publications

In vitro Study of Remineralization of Dentin: Effects of Ions on Mineral Induction by Decalcified Dentin Matrix

In vitro Study of Remineralization of Dentin: Effects of Ions on Mineral Induction by Decalcified Dentin Matrix

Effects of incorporation of nano-fluorapatite particles on microhardness, fluoride releasing properties, and biocompatibility of a conventional glass ionomer cement (GIC)

Role of the cell membrane in pH-dependent fluoride inhibition of glucose uptake by Streptococcus mutans

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