Physicochemical characterization and in vitro behavior of daunorubicin-loaded poly(butylcyanoacrylate) nanoparticles

Simeonova, Margarita; Ivanova, Galya; Enchev, Venelin; Маркова, Н.; Kamburov, M.; Petkov, Christo; Devery, Aoife; O’Connor, Robert; Brougham, Dermot F.

doi:10.1016/j.actbio.2009.01.026

Cited by 47 publications

(41 citation statements)

References 28 publications

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“…All results indicated that PUE did not participate in the polymerization reaction and was only encapsulated in PBCN by possible intermolecular forces such as hydrogen bond. Similar results were obtained in the previous report [26].…”

Section: Characterization Of Pue-pbcn As Shown Insupporting

confidence: 93%

Enhancement of Oral Bioavailability of Puerarin by Polybutylcyanoacrylate Nanoparticles

Zhao

Liu

Sun

et al. 2011

Journal of Nanomaterials

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The interest using novel drug delivery systems to improve oral bioavailability of drug with poor solubility is increasing. In this study, a new oral delivery system, polybutylcyanoacrylate nanoparticles (PBCNs), was introduced to improve the oral bioavailability of puerarin (PUE). PUE-loaded PBCN was successfully prepared by anionic polymerization method. Characterization of PUE-loaded PBCN was evaluated with morphology, size, zeta potential, and in vitro release study. The PBCN loading PUE exhibited a spherical shape under transmission electron microscopy with an average size of 159.4 nm, and the zeta potential was −15.0 mV. The in vitro release of PUE-loaded PBCN showed an initial burst release followed by a sustained release. Physicochemical state of PUE in PBCN was investigated by differential scanning colorimetry, X-ray diffraction, and Fourier transform infrared spectroscopy. The results indicated that PUE in PBCN was in a noncrystalline state. The oral pharmacokinetic study in rats showed that the relative bioavailability of PUE-encapsulated PBCN to the crude PUE was more than 550%. It can be concluded that PBCN as an oral drug carrier can significantly improve the oral bioavailability of PUE.

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Section: Characterization Of Pue-pbcn As Shown Insupporting

confidence: 93%

Enhancement of Oral Bioavailability of Puerarin by Polybutylcyanoacrylate Nanoparticles

Zhao

Liu

Sun

et al. 2011

Journal of Nanomaterials

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“…Furthermore the authors reported a significant decrease of the systemic drug toxicity in mice and much higher antitumor efficacy in vivo of the nanoformulation compared to the free drug. Similar results have also been obtained with nanoformulations of other anticancer drugs: pirarubicin (Greish et al, 2005), tanespimycin (Larson et al, 2011), daunorubicin (Simeonova et al, 2009), etc. In all these cases, the obtained decrease of the drug cytotoxicity after association with nanocarriers has been explained with the long-term retention of significant quantities of drug bound to nanoparticles in the cellular environment.…”

Section: Discussionsupporting

confidence: 83%

Epirubicin loading in poly(butyl cyanoacrylate) nanoparticles manifests via altered intracellular localization and cellular response in cervical carcinoma (HeLa) cells

et al. 2014

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Our studies revealed decreased cytotoxicity of the nanoparticle-formulated epirubicin compared to the free drug as well as a noticeable change in the drug's intracellular localization. Epirubicin-loaded nanoparticles were internalized via endocytosis, accumulated inside endosomal vesicles and induced a two-fold stronger pro-apoptotic signal when compared to the free drug. The level of the tumor suppressor protein p53 in HeLa cells increased significantly upon treatment with free epirubicin, but remained relatively unchanged when cells were treated with equivalent dose of nanoparticle-loaded drug, suggesting a possible shift from p53-dependent DNA/RNA intercalation-based induction of cytotoxicity by free epirubicin to a caspase 3-induced cell death by the epirubicin-loaded PBCA formulation.

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“…37 % Entrapment efficiency Initial concentration of drug Drug content in the supernatant Initialconcentration of drug x 100 A fixed amount of BTZ (2 mM) was added to a 20 wt.% solution of HEDO in dimethylformamide, and the solution was kept overnight in a shaking incubator at room temperature to initiate complexation between the catechol functionalities and the boronic acid active site of BTZ.…”

Section: 6mentioning

confidence: 99%

A smart magnetic nanoplatform for synergistic anticancer therapy: manoeuvring mussel-inspired functional magnetic nanoparticles for pH responsive anticancer drug delivery and hyperthermia

et al. 2015

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We report the versatile design of a smart nanoplatform for thermo-chemotherapy treatment of cancer. For the first time in the literature, our design takes advantage of the outstanding properties of mussel-inspired multiple catecholic groups - presenting a unique copolymer poly(2-hydroxyethyl methacrylate-co-dopamine methacrylamide) p(HEMA-co-DMA) to surface functionalize the superparamagnetic iron oxide nanoparticles as well as to conjugate borate containing anticancer drug bortezomib (BTZ) in a pH-dependent manner for the synergistic anticancer treatment. The unique multiple anchoring groups can be used to substantially improve the affinity of the ligands to the surfaces of the nanoparticles to form ultrastable iron oxide nanoparticles with control over their hydrodynamic diameter and interfacial chemistry. Thus the BTZ-incorporated-bio-inspired-smart magnetic nanoplatform will act as a hyperthermic agent that delivers heat when an alternating magnetic field is applied while the BTZ-bound catechol moieties act as chemotherapeutic agents in a cancer environment by providing pH-dependent drug release for the synergistic thermo-chemotherapy application. The anticancer efficacy of these bio-inspired multifunctional smart magnetic nanoparticles was tested both in vitro and in vivo and found that these unique magnetic nanoplatforms can be established to endow for the next generation of nanomedicine for efficient and safe cancer therapy.

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Physicochemical characterization and in vitro behavior of daunorubicin-loaded poly(butylcyanoacrylate) nanoparticles

Cited by 47 publications

References 28 publications

Enhancement of Oral Bioavailability of Puerarin by Polybutylcyanoacrylate Nanoparticles

Enhancement of Oral Bioavailability of Puerarin by Polybutylcyanoacrylate Nanoparticles

Epirubicin loading in poly(butyl cyanoacrylate) nanoparticles manifests via altered intracellular localization and cellular response in cervical carcinoma (HeLa) cells

A smart magnetic nanoplatform for synergistic anticancer therapy: manoeuvring mussel-inspired functional magnetic nanoparticles for pH responsive anticancer drug delivery and hyperthermia

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