Physicochemical characterization of indomethacin polymorphs and the transformation kinetics in ethanol.

Kaneniwa, Nobuyoshi; Otsuka, Makoto; Hayashi, Tetsuo

doi:10.1248/cpb.33.3447

Cited by 152 publications

(139 citation statements)

References 0 publications

Supporting

Mentioning

123

Contrasting

Unclassified

Order By: Relevance

“…2) were identical to those reported previously. 9,10,16,17) The results of TG and HPLC suggested that each of the polymorphs was not solvated and did not decompose.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A Novel Method for Estimation of Transition Temperature for Polymorphic Pairs in Pharmaceuticals Using Heat of Solution and Solubility Data.

Urakami

Shono

Higashi

et al. 2002

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

“…2) were identical to those reported previously. 9,10,16,17) The results of TG and HPLC suggested that each of the polymorphs was not solvated and did not decompose.…”

Section: Resultsmentioning

confidence: 99%

“…Acetazolamide Polymorphs: Form A was prepared by the method of Umeda 16) as follows. Acetazolamide (5 g) was dissolved in 700 ml of methanol at 65°C, and the solution was cooled slowly and maintained at 5°C overnight.…”

Section: Methodsmentioning

confidence: 99%

A Novel Method for Estimation of Transition Temperature for Polymorphic Pairs in Pharmaceuticals Using Heat of Solution and Solubility Data.

Urakami

Shono

Higashi

et al. 2002

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

“…Fig. 2 shows the X-ray diffractograms of pure indomethacin and pure excipients, a physical mixture of the conventional formulation (indomethacin, avicel and silica) and liquisolid formula- (16)(17)(18)(19). As it is clear from Fig.…”

Section: Resultsmentioning

confidence: 99%

Liquisolid technique as a tool for enhancement of poorly water-soluble drugs and evaluation of their physicochemical properties

Javadzadeh¹,

Siahi²,

Asnaashari³

et al. 2007

Acta Pharmaceutica

View full text Add to dashboard Cite

The potential of liquisolid systems to improve the dissolution properties of a water-insoluble agent (indomethacin) was investigated. In this study, different formulations of liquisolid tablets using different co-solvents (non-volatile solvents) were prepared and the effect of aging on the dissolution behaviour of indomethacin liquisolid compacts was investigated. To evaluate any interaction between indomethacin and the other components in liquisolid formulations, X-ray powder diffraction (XPD) and differential scanning calorimetry (DSC) were used. Dissolution test was carried out at two different pH, 1.2 and 7.2, to simulate the stomach or intestine fluid, respectively. The results showed that liquisolid formulations exhibited significantly higher drug dissolution rates at pH 1.2 and 7.2 compared to compacts prepared by the direct compression technique. The enhanced rate of indomethacin dissolution from liquisolid tablets was probably due to an increase in wetting properties and surface area of drug particles available for dissolution. In order to investigate the effect of aging on the hardness and dissolution rate of liquisolid compacts, the formulations were stored at 25°C /75% relative humidity for a period of 12 months. The results showed that aging had no significant effect on dissolution profiles of liquisolid tablets. Liquisolid compacts containing propylene glycol as vehicle produced higher dissolution rates in comparison with liquisolid compacts containing PEG 400 or Tween 80 of the same concentration. The DSC and XPD results showed no changes in crystallinity of the drug and interaction between indomethacin and excipients (Avicel and silica) during the process.

show abstract

“…Otsuka et al [24] reported the isolation of Form B of phenobarbital by adding a saturated methanolic solution of the compound drop-wise into water, whereas Form E was obtained by replacing methanol with dioxane. The α-form of indomethacin has been prepared by dissolving the compound in methanol and precipitating with water [25].…”

Section: Art Of Synthesis Of Desired Polymorphs: a Reviewmentioning

confidence: 99%

Art of Synthesis of Desired Polymorphs: A Review

Tandon¹,

Tandon²,

Gupta³

2017

Asian J. Chem.

View full text Add to dashboard Cite

Polymorphism plays an important role in drug solubility and availability. The study of the polymorphism of active pharmaceutical ingredients has become crucial for the synthesis of active pharmaceutical ingredients. This review provides observations, synthetic methods and characterization techniques for polymorphs using the latest analytical techniques. The desired polymorph can be obtained by choosing the proper nucleation mechanism.

show abstract

Physicochemical characterization of indomethacin polymorphs and the transformation kinetics in ethanol.

Cited by 152 publications

References 0 publications

A Novel Method for Estimation of Transition Temperature for Polymorphic Pairs in Pharmaceuticals Using Heat of Solution and Solubility Data.

A Novel Method for Estimation of Transition Temperature for Polymorphic Pairs in Pharmaceuticals Using Heat of Solution and Solubility Data.

Liquisolid technique as a tool for enhancement of poorly water-soluble drugs and evaluation of their physicochemical properties

Art of Synthesis of Desired Polymorphs: A Review

Contact Info

Product

Resources

About