Physicochemical effects of terpenes on organogel for transdermal drug delivery

Lim, Perry Fung Chye; Liu, Xiang Yang; Kang, Lifeng; Ho, Peiying; Chan, Sui Yung

doi:10.1016/j.ijpharm.2008.02.021

Cited by 34 publications

(11 citation statements)

References 16 publications

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“…GPI is an organogelator, which is an amino-acid-type gelator. For improving the penetration rate of bioactive agents except limonene, some other penetration enhancers like farnesol, cineole and linalool can also be used to incorporate in GPI organogels 20 .…”

Section: Premium Lecithin Organogels (Prlos)mentioning

confidence: 99%

Untitled

2018

IJPSR

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Pluronic lecithin organogels (PLOs) are thermodynamically stable, biocompatible, viscoelastic with improve drug permeation and localised action. PLOs have gained much popularity compared with other traditional topical and transdermal drug delivery system owing to their lower cost, flexibility of dose and longer contact time. PLOs enhances the permeability of drugs because of desired drug partitioning, modification of skin barrier system by its components and biphasic drug solubility that is it enhanced solubility of poorly soluble drugs and increased penetrability of hydrophilic drugs. In this review we discuss the insights of PLOs as topical and transdermal drug delivery system. QUICK RESPONSE CODE

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Section: Premium Lecithin Organogels (Prlos)mentioning

confidence: 99%

Untitled

2018

IJPSR

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“…Presence of shear thinning behavior with thixotropic properties is considered to be essential property for topical formulations. [43] In addition to this, the semi-solid nature of MG and GG gels at low shear rates allow their long-term stability during storage. [43,44] 3.9.…”

Section: Rheological Studiesmentioning

confidence: 99%

“…[43] In addition to this, the semi-solid nature of MG and GG gels at low shear rates allow their long-term stability during storage. [43,44] 3.9. Spreadability studies The % spreadability with respect to varying weights has been shown in Figure 10.…”

Section: Rheological Studiesmentioning

confidence: 99%

Development of mustard oil- and groundnut oil-based span 40 organogels as matrices for controlled drug delivery

Satapathy

Sagiri

Pal

et al. 2013

Designed Monomers and Polymers

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The present study deals with the development and characterization of sorbitan monopalmitate (SM) organogels using mustard oil (MO) and groundnut oil (GO) as the apolar phase. In both the cases, the organogels containing ≥ 20% (w/w) SM were found to be stable for prolonged period. The microscopic studies showed the presence of aggregates of tubular shaped gelator fibers in the gel architecture. Fourier transform infrared spectroscopy indicated formation of intermolecular hydrogen bonding amongst the oil and gelator molecules. Differential scanning colorimetry studies indicated that the thermal stability of GO organogels was found to be more than the MO organogels. Gels showed pseudoplastic flow, with shear thinning and thixotropic behavior. The drug release from the organogels followed Higuchian kinetics with non-Fickian diffusion. The pH values of organogels were found to be near the human skin pH and highly hemocompatible. Metronidazole loaded organogels have shown good antimicrobial activity against Bacillus subtilis. Based on the preliminary studies, the developed organogels may be tried as drug carriers.

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“…The ability of limonene to control the growth of bacteria, yeast and spoilage microflora of fruit juices has already been demonstrated in vitro, indicating the promising use of this EO as a strategy to extend microbial shelf‐life of food products (Conte and others ; Bevilacqua and others 2010). However, there are practical challenges in using EO in foods: they are readily oxidized or hydrolyzed to give off flavors, and because of their relative hydrophobicity and insolubility in water (that is, log P = 4.83) they can be hard to incorporate into aqueous foods (Lim and others ; Liang and others ). Both of these challenges can be overcome by encapsulating EO in emulsions.…”

Section: Introductionmentioning

confidence: 99%

Essential Oils Against Pathogen and Spoilage Microorganisms of Fruit Juices: Use of Versatile Antimicrobial Delivery Systems

Trinetta

Morgan

Coupland

et al. 2017

Journal of Food Science

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Essential oils (EO) are increasingly used as natural antimicrobial compounds, however the effect of delivery system to enhance their antimicrobial activity has not been widely studied. Limonene (0 to 10 μL/mL) was added to microbial suspensions (∼10 CFU/mL) of selected foodborne pathogens (Listeria monocytogenes Scott A, Salmonella enterica Typhimurium, Escherichia coli and Staphylococcus aureus), and spoilage microorganisms (Lactobacillus plantarum, Saccharomyces cerevisiae, and Candida albicans). S. aureus was found to be the most sensitive foodborne pathogen while Salmonella enterica showed continued growth under all concentrations. Stable nanoemulsions and solid lipid nanoparticles (SLN) (d ∼ 170 nm) were prepared using an alkane carrier oil (n-tetradecane and n-eicosane, respectively). Interfacial effects and homogenous distribution of limonene in nanoemulsions improved its (8 and 12 μL/mL) antimicrobial effect against S. aureus. Higher aqueous concentrations as a result of expulsion from SLN further enhanced the antimicrobial activity pronounced at higher limonene concentrations. Therefore, our findings confirm that the emulsion-based delivery systems are able to effectively distribute limonene inside a microbial suspension to improve its antimicrobial activity.

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Physicochemical effects of terpenes on organogel for transdermal drug delivery

Cited by 34 publications

References 16 publications

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Untitled

Development of mustard oil- and groundnut oil-based span 40 organogels as matrices for controlled drug delivery

Essential Oils Against Pathogen and Spoilage Microorganisms of Fruit Juices: Use of Versatile Antimicrobial Delivery Systems

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