Physicochemical insights into the micelle-based drug-delivery of bioactive compounds to the carrier protein

The introduction of cancer therapeutics and nanotechnology has resulted in a paradigm shift from conventional therapy to precision medicine. Nanotechnology, an interdisciplinary field with a focus on biomedical applications, holds immense promise in bringing about novel approaches for cancer detection, diagnosis, and therapy. The past decade has witnessed significant research and material applications related to nanoparticles (NPs). NPs differ from small-molecule drugs as they possess unique physicochemical characteristics, such as a large surface-to-volume ratio, enabling them to penetrate live cells efficiently. Traditional cancer therapies, such as chemotherapy, radiation therapy, targeted therapy, and immunotherapy, have limitations, such as cytotoxicity, lack of specificity, and multiple drug resistance, which pose significant challenges for effective cancer treatment. However, nanomaterials have unique properties that enable new therapeutic modalities beyond conventional drug delivery in the fight against cancer. Moreover, nanoparticles (1–100 nm) have numerous benefits, such as biocompatibility, reduced toxicity, excellent stability, enhanced permeability and retention effect, and precise targeting, making them ideal for cancer treatment. The purpose of this article is to provide consolidated information on various bio-inspired nanoparticles that aid in cancer theranostics.

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Physicochemical insights into the micelle-based drug-delivery of bioactive compounds to the carrier protein

Abstract: Micelles can be effectively used as drug delivery systems due to their ability to encapsulate a wide range of drugs. In addition, they can carry and deliver the therapeutics to...

Cited by 3 publications

References 32 publications

Milk protein-based carrier system for encapsulation of dietary polyphenol rutin: Molecular-level interactions and enhanced bioactivities

Milk protein-based carrier system for encapsulation of dietary polyphenol rutin: Molecular-level interactions and enhanced bioactivities

Role of functional group orientation in the drug partitioning and micelle-mediated delivery of quinoline family drugs to the carrier protein

Recent Advancement of Bio-Inspired Nanoparticles in Cancer Theragnostic

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