Physicochemical investigations of biogenic chitosan-silver nanocomposite as antimicrobial and anticancer agent

Nithya, A.; Kumari, Henry Linda Jeeva; Mohan, Singaravelu Chandra; Kandasamy, Ruckmani; Jothivenkatachalam, Kandasamy

doi:10.1016/j.ijbiomac.2016.07.003

Cited by 79 publications

(35 citation statements)

References 48 publications

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“…Similar antibacterial effectiveness was also exhibited by nanocomposites of chitosan and nanosilver, which demonstrated significant antimicrobial activity against Gram-negative Salmonella and a potent anticancer effect [21], reduced fungal growth and caused morphological and ultrastructural changes in the pathogen [22], and were effective against S. aureus, Bacillus sp., E. coli, Proteus sp., Pseudomonas sp., Serratia sp., and Klebsiella sp. and the fungal pathogens Aspergillus niger, Aspergillus flavus, Aspergillus fumigatus, and Candida albicans [23].…”

Section: Introductionmentioning

confidence: 56%

Electrophoretic Deposition and Characteristics of Chitosan–Nanosilver Composite Coatings on a Nanotubular TiO2 Layer

et al. 2020

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The surface treatment of titanium implants has been applied mainly to increase surface bioactivity and, more recently, to introduce antibacterial properties. To this end, composite coatings have been investigated, particularly those based on hydroxyapatite. The present research was aimed at the development of another coating type, chitosan–nanosilver, deposited on a Ti13Zr13Nb alloy. The research comprised characterization of the coating’s microstructure and morphology, time-dependent nanosilver dissolution in simulated body fluid, and investigation of the nanomechanical properties of surface coatings composed of chitosan and nanosilver, with or without a surface-active substance, deposited at different voltages for 1 min on a nanotubular TiO2 layer. The microstructure, morphology, topography, and phase composition were examined, and the silver dissolution rate in simulated body fluid, nanoscale mechanical properties, and water contact angle were measured. The voltage value significantly influenced surface roughness. All specimens possessed high biocompatibility. The highest and best adhesion of the coatings was observed in the absence of a surface-active substance. Silver dissolution caused the appearance of silver ions in solution at levels effective against bacteria and below the upper safe limit value.

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Section: Introductionmentioning

confidence: 56%

Electrophoretic Deposition and Characteristics of Chitosan–Nanosilver Composite Coatings on a Nanotubular TiO2 Layer

et al. 2020

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“…The sharp peak at 1375 cm −1 is attributed to the C-N stretching vibration. The bands at 1048 cm −1 and 1083 cm −1 are assigned to the stretching vibrations of C-O-C and C-OH, respectively [24,25]. These results demonstrated that biomolecules of the yeast extract were responsible for the biosynthesis of Ag NPs.…”

Section: Structural Characterization Of Ag Npsmentioning

confidence: 73%

Biosynthesis and Antibacterial Activity of Silver Nanoparticles Using Yeast Extract as Reducing and Capping Agents

Shu¹,

He²,

et al. 2020

Nanoscale Res Lett

145

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Biosynthesis for the preparation of antimicrobial silver nanoparticles (Ag NPs) is a green method without the use of cytotoxic reducing and surfactant agents. Herein, shape-controlled and well-dispersed Ag NPs were biosynthesized using yeast extract as reducing and capping agents. The synthesized Ag NPs exhibited a uniform spherical shape and fine size, with an average size of 13.8 nm. The biomolecules of reductive amino acids, alpha-linolenic acid, and carbohydrates in yeast extract have a significant role in the formation of Ag NPs, which was proved by the Fourier transform infrared spectroscopy analysis. In addition, amino acids on the surface of Ag NPs carry net negative charges which maximize the electrostatic repulsion interactions in alkaline solution, providing favorable stability for more than a year without precipitation. The Ag NPs in combination treatment with ampicillin reversed the resistance in ampicillinresistant E. coli cells. These monodispersed Ag NPs could be a promising alternative for the disinfection of multidrugresistant bacterial strains, and they showed negligible cytotoxicity and good biocompatibility toward Cos-7 cells.

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“…129 Chitosan/TiO 2 / Ag nanocomposites exhibited effective antibacterial activity via ROS generation, lactate dehydrogenase release and inhibited bacterial adhesion. 130 Chitosan/Ag nanocomposites were effective against Salmonella sp., 131 whereas the activity of chitosan-TiO 2 :Cu nanocomposite against E. coli and S. aureus was enhanced in the presence of light. 132 Chitosan/ calcium silicate nanocomposites doped with Ag + exhibited antibacterial activity against S. aureus and P. aeruginosa.…”

Section: Polymeric Nanocomposites and Nanomaterials Conjugated With Amentioning

confidence: 97%

Nanomaterials for alternative antibacterial therapy

Hemeg

2017

IJN

441

262

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Despite an array of cogent antibiotics, bacterial infections, notably those produced by nosocomial pathogens, still remain a leading factor of morbidity and mortality around the globe. They target the severely ill, hospitalized and immunocompromised patients with incapacitated immune system, who are prone to infections. The choice of antimicrobial therapy is largely empirical and not devoid of toxicity, hypersensitivity, teratogenicity and/or mutagenicity. The emergence of multidrug-resistant bacteria further intensifies the clinical predicament as it directly impacts public health due to diminished potency of current antibiotics. In addition, there is an escalating concern with respect to biofilm-associated infections that are refractory to the presently available antimicrobial armory, leaving almost no therapeutic option. Hence, there is a dire need to develop alternate antibacterial agents. The past decade has witnessed a substantial upsurge in the global use of nanomedicines as innovative tools for combating the high rates of antimicrobial resistance. Antibacterial activity of metal and metal oxide nanoparticles (NPs) has been extensively reported. The microbes are eliminated either by microbicidal effects of the NPs, such as release of free metal ions culminating in cell membrane damage, DNA interactions or free radical generation, or by microbiostatic effects coupled with killing potentiated by the host’s immune system. This review encompasses the magnitude of multidrug resistance in nosocomial infections, bacterial evasion of the host immune system, mechanisms used by bacteria to develop drug resistance and the use of nanomaterials based on metals to overcome these challenges. The diverse annihilative effects of conventional and biogenic metal NPs for antibacterial activity are also discussed. The use of polymer-based nanomaterials and nanocomposites, alone or functionalized with ligands, antibodies or antibiotics, as alternative antimicrobial agents for treating severe bacterial infections is also discussed. Combinatorial therapy with metallic NPs, as adjunct to the existing antibiotics, may aid to restrain the mounting menace of bacterial resistance and nosocomial threat.

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Physicochemical investigations of biogenic chitosan-silver nanocomposite as antimicrobial and anticancer agent

Cited by 79 publications

References 48 publications

Electrophoretic Deposition and Characteristics of Chitosan–Nanosilver Composite Coatings on a Nanotubular TiO2 Layer

Electrophoretic Deposition and Characteristics of Chitosan–Nanosilver Composite Coatings on a Nanotubular TiO2 Layer

Biosynthesis and Antibacterial Activity of Silver Nanoparticles Using Yeast Extract as Reducing and Capping Agents

Nanomaterials for alternative antibacterial therapy

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