Physicochemical model of retention for capillary supercritical fluid chromatography

Luffer, Debra R.; Ecknig, Wilhelm; Novotný, Miloš V.

doi:10.1016/s0021-9673(01)93069-9

Cited by 22 publications

(7 citation statements)

References 21 publications

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“…This can be realized, for example, under linear chromatographic conditions, as the Henry's constant of a solute decreases when the density of the supercritical eluent increases. 7 The same phenomenon has been observed under nonlinear competitive conditions, i.e., when the column is overloaded, where an increase of the supercritical eluent density corresponds to a decrease of the adsorbed loading. Juding from these observations, it can be concluded that a decreasing pressure gradient along the four sections of a SMB unit operated under supercritical conditions (i.e., SF-SMB in the pressure-gradient mode) yields decreasing elution strength and therefore better performance than a SF-SMB unit operated in the isocratic mode, i.e., with uniform pressure.…”

Section: Introductionmentioning

confidence: 54%

“…In addition, the easy tunability of the properties of a supercritical solvent is particularly attractive in SMB processes where each of the four sections of the unit plays a different role and, therefore, requires a different elution strength to achieve optimal performance. This can be realized, for example, under linear chromatographic conditions, as the Henry's constant of a solute decreases when the density of the supercritical eluent increases . The same phenomenon has been observed under nonlinear competitive conditions, i.e., when the column is overloaded, where an increase of the supercritical eluent density corresponds to a decrease of the adsorbed loading.…”

Section: Introductionmentioning

confidence: 74%

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Enantioseparation through Supercritical Fluid Simulated Moving Bed (SF-SMB) Chromatography

Denet¹,

Hauck²,

Nicoud³

et al. 2001

Ind. Eng. Chem. Res.

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In this work, the first enantioseparation in a SF-SMB unit, i.e., a simulated moving bed (SMB) operated under supercritical conditions, is reported. Complete separation of the two enantiomers of tetralol was achieved both in the pressure-gradient mode (where a pressure gradient is imposed along the four sections of the unit) and in the isocratic mode (where the pressure is kept constant). However, an almost 3-fold increase in productivity could be achieved in the pressure-gradient rather than the isocratic mode. The obtained results are explained and rationalized using recently developed design criteria for SMBs, the so-called "triangle theory", which have been properly extended to allow for different pressure values in the different sections of the unit.

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Section: Introductionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 74%

Enantioseparation through Supercritical Fluid Simulated Moving Bed (SF-SMB) Chromatography

Denet¹,

Hauck²,

Nicoud³

et al. 2001

Ind. Eng. Chem. Res.

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“…Many studies applied EM that predicts the behaviors of a system based on empirical observations to explain pSFC chromatographic behaviors of many compound groups (e.g. tocopherols, alkanes, PAHs, hexadecane, fluoranthene, phenolic derivatives, carboxylic methyl esters, triglycerides, organic acids, amines, and amides) 114,116–128 …”

Section: Psfc Retention Mechanism Studiesmentioning

confidence: 99%

A review of retention mechanism studies for packed column supercritical fluid chromatography

Si-Hung

Bamba

2021

Analytical Science Advances

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The packed column supercritical fluid chromatography has risen as a promising alternative separation technique to the conventional liquid chromatography and gas chromatography. Although the packed column supercritical fluid chromatography has many advantages compared to other chromatographic techniques, its separation mechanism is not fully understood due to the complex combination effects of many chromatographic parameters on separation quality and the lacking of global strategies for studying separation mechanisms. This review aims to provide recent information regarding the chromatographic behaviors and the effects of the parameters on the separation, discuss the results, and point out the remaining bottlenecks in the packed column supercritical fluid chromatography retention mechanism studies.

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“…The solute volatility depends on the Eq2 where a and b are temperature-dependent constants. Luffer and co-workers (11) expanded Equation 2to develop an em pirical equation for the capacity factor of polycyclic aromatic hydrocarbons. The logarithm of the capacity factor was also shown to correlate with density (at constant temperature) in a quadratic form (12,13).…”

Section: Eqlmentioning

confidence: 99%

An Empirical Approach for Predicting Retention Characteristics in Supercritical Fluid Chromatography

Mitra¹,

Shi²,

Du³

1996

Journal of Chromatographic Science

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The retention process in supercritical fluid chromatography depends on the solute volatility as well as the strength of the mobile phase. When the capacity factor is plotted as a function of temperature at constant pressure, the curve passes through a maximum point. At higher temperatures, the capacity factor decreases as the temperature increases, and at lower temperatures the opposite is observed. This makes prediction of the capacity factor in supercritical fluid chromatography complicated. Rigorous thermodynamic equations to predict retention characteristics result in complex equations. A simple empirical approach for prediction of the capacity factor as a function of mobile phase density and column temperature is presented.

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Physicochemical model of retention for capillary supercritical fluid chromatography

Cited by 22 publications

References 21 publications

Enantioseparation through Supercritical Fluid Simulated Moving Bed (SF-SMB) Chromatography

Enantioseparation through Supercritical Fluid Simulated Moving Bed (SF-SMB) Chromatography

A review of retention mechanism studies for packed column supercritical fluid chromatography

An Empirical Approach for Predicting Retention Characteristics in Supercritical Fluid Chromatography

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