Physicochemical properties and antioxidant activity of gamma-oryzanol-loaded liposome formulations for topical use

Viriyaroj, Amornrat; Ngawhirunpat, Tanasait; Sukma, Monrudee; Akkaramongkolporn, Prasert; Ruktanonchai, Uracha; Opanasopit, Praneet

doi:10.1080/10837450902911937

Cited by 3 publications

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“…Accompanied by the conversion of lamellar structures to vesicular particles, CHO and PA might be incorporated into the molecular spaces and so can meaningfully decrease the size of vesicular particles (Pezeshky et al, 2016). These results were similar to the results of Viriyaroj et al (2009) that stated the use of CHO in liposomal formulations led to the reduction of particle size.…”

Section: Particle Size Distribution Of Liposomessupporting

confidence: 80%

Controlled release and improved stability of vitaminD3within nanoliposomes stabilized by palmitic acid

Molaveisi¹,

Shahidi‐Noghabi²,

Naji‐Tabasi³

2021

Journal of Food Safety

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The entrapment of fat-soluble vitamins in liposomes is an effective technique to protect them from optical and chemical degradation and oxidation. In this study palmitic acid (PA) was incorporated into the liposomal membrane to increase the stability of the nanoliposomes loaded with vitamin D3 (VD3). The liposomal formulations were prepared by the thin-layer hydration method with different rations of soy phosphatidylcholine (SPC), cholesterol (CHO), and PA as membrane compounds. The encapsulation efficiency (EE%), particle size, particle size distribution, zeta potential, thermal properties, morphology, stability, antioxidant activity, moisture content, solubility, and in vitro release of nanoliposomes were studied. Results showed that the addition of PA to nanoliposomes in the proportions of 1% increased the EE, stability, antioxidant activity, moisture content, and solubility but reduced their particle size, particle size distribution, and zeta potential. Furthermore, the spectra of Fourier transform infrared (FTIR) spectroscopy showed that the complex formed between VD3 and PA was a physical interaction. The high release of VD3 (95.4%) in the intestine medium followed the Fickian diffusion mechanism. Generally, the incorporation of PA in nanoliposomes is a promising approach to improve the stability of VD3-loaded liposomes during storage.

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Section: Particle Size Distribution Of Liposomessupporting

confidence: 80%

Controlled release and improved stability of vitaminD3within nanoliposomes stabilized by palmitic acid

Molaveisi¹,

Shahidi‐Noghabi²,

Naji‐Tabasi³

2021

Journal of Food Safety

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“…EE of CO nanoliposome was calculated by the method reported for gamma‐oryzanol‐loaded liposome (Viriyaroj et al., 2009), with few modifications. CO was extracted from 1 mL dialysed liposome using 4 mL of chloroform by vortexing it for 5 min.…”

Section: Methodsmentioning

confidence: 99%

Nanoliposomal encapsulation of chia oil for sustained delivery of α‐linolenic acid

Choudhary

Dutta

Moses

et al. 2021

Int J of Food Sci Tech

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Summary Chia oil is a popular source of ω‐3 fatty acids, typically α‐linolenic acid. This study reports the encapsulation of chia oil in nanoliposome to protect ω‐3 fatty acids and to obtain a sustained release of chia oil during digestion. Nanoliposomal encapsulation was carried out using solvent evaporation, followed by sonication. The encapsulation process was conducted using different lipid contents, with different concentrations of soy phosphatidylcholine (S), Tween 80 (T) and volumes of the aqueous phase. The maximum encapsulation efficiency was found to be 88.31%, and the average particle size was 49.25 nm; a moderate repulsion among the particles was observed. Differential scanning calorimetry study revealed enhanced thermal stability of chia oil in nanoliposomes. A negligible release (3.39%) of encapsulated chia oil was observed in the simulated gastric fluid, and a 74.72% sustained release was recorded in the simulated intestinal fluid. This formulation can be a suitable supplement of ω‐3 fatty acids for food and therapeutic applications.

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“…A relative simple concept of packing an active molecule with a lipid component was first described by [1,2], after Bangham had described the characteristics of lamellae of swollen phospholipids in 1965 [3]. The idea of using liposomes as nanocarriers was then developed and improved by a thousand of laboratories all over the world and applied in varied different fields from cosmetic [4] to cancer treatment, and this review will mainly focus on this latter domain.…”

Section: Introductionmentioning

confidence: 99%

Anticancer Drugs in Liposomal Nanodevices: A Target Delivery for a Targeted Therapy

Urbinati

Marsaud²,

Renoir³

2012

CTMC

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For many years, nanocarriers have been investigated to modify pharmacokinetics and biodistribution of various active molecules. In the cancer domain, one of the biggest challenges still remains the improvement of the therapeutic index, often too low, for the majority of antitumor drugs. The application of nanotechnologies for the treatment and the diagnosis of cancers are nowadays currently developed, or under development, and liposomes play an important role in the history of nanodevices. Because of their high degree of biocompatibility, lipid nanosystems have been used to improve pharmacological profiles of various anticancer drugs otherwise discarded because of their low water solubility, poor bioavailability or either fragile and subjected to rapid biotransformations. This review aims at introducing an overview of the last 40 years of liposome researches until the last liposomal formulations commercially available or undergoing clinical trials. Liposome properties will be described, with a particular emphasis over the last generation of carriers appreciated for their active targeting characteristics. Researchers foresee a remarkable impact of nanotechnologies in the field of medicine; this review will try to summarize the main concepts over liposome domain, which can count on encouraging results as target therapy associated with targeted delivery.

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Physicochemical properties and antioxidant activity of gamma-oryzanol-loaded liposome formulations for topical use

Cited by 3 publications

References 0 publications

Controlled release and improved stability of vitaminD3within nanoliposomes stabilized by palmitic acid

Controlled release and improved stability of vitaminD3within nanoliposomes stabilized by palmitic acid

Nanoliposomal encapsulation of chia oil for sustained delivery of α‐linolenic acid

Anticancer Drugs in Liposomal Nanodevices: A Target Delivery for a Targeted Therapy

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