Physicochemical Properties and Biological Activities of Novel Hydrazonate Copper Complexes

Abstract

The objective of this research was to elucidate the biological effect of novel compounds derived from natural product of syringaldehyde through novel semi-synthetic method in order to investigate the physicochemical properties and biological activities by using DPPH and FRAP techniques and its antibacterial activities against Klebsiella spp., Pseudomonas aeruginosa, Bacillus cereus, and Staphylococcus aureus. Moreover, to examine its ability against breast cancer cell line (MCF-7). The results showed that the syringaldehyde hydrazonate copper complexes possessed the covalent bonds with square-planar structure. In terms of antioxidant DPPH activities, it was found that syringaldehyde hydrazone possessed high potency against DPPH free radicals, with respect to syringaldehyde hydrazonate copper complexes. On the other hand, all compounds possessed low reducing properties for changing Fe 3+ to Fe 2+ in FRAP technique. For antibacterial activities revealed that the ligand L1 and L5 possessed high effect on Pseudomonas aeruginosa, but for all copper complexes possessed high potent antibacterial susceptibility to four bacteria with concentration dependence. For anti-breast cancer cell line (MCF-7), it was found that all compounds possessed high potent anticancer susceptibility with low IC 50 , especially, compound exhibit highly potency effective is C5 (IC 50 9.75 μM). The tendency of anticancer effect from high to low was C5 > C2 > C1 > C4 > C3. Therefore, all synthetic compounds obtained from the present research possibly develop as the antibacterial drugs and the drugs for curing the diseases caused by free radicals, including breast cancer in metastatic phase. The most important feature of these drugs was the high specificity to the target and harmless to the normal cells.

Synthesis and Physico-Chemical Characterizations of Novel Hydrazone Ligands and Their Metal Complexes against Hormone-Dependent and Independent Cancers

“…Add sample element 5 µL diluted by DMSO 5% mixed with 384-well plated and incubate at a temperature of 37˚C with 5% of CO 2 for 3 days, then add solution resazurin 62.5 µg/mL 12.5 µL, incubate 4 hours at a temperature of 37˚C. Then draw a graph for the relation between the concentration and the value of the response of cell inhibition [11] [12] [13].…”

A Novel Method of Self-Cross-Linking of Syringaldehyde with Activated Methoxy Groups via Cross-Coupling for Lignin-Based Wood Adhesives

“…37 Hence, the SA model compound is a potential lignin compound with a methoxy group in two meta positions, due to numerous studies of SA depolymerization from lignin with stable conditions and high yield. 38 SA has been studied for its biological effects using a semisynthetic method, 39 and the excellent performance of SA has indicated the application potential of this compound in thermoset polymer. 40−42 The objectives of this work are to activate the methoxy groups of the SA model compound and to cross-link the activated SA to build thermosetting polymers with a network structure as lignin-based adhesives for bonding wood.…”

“…Hence, the SA model compound is a potential lignin compound with a methoxy group in two meta positions, due to numerous studies of SA depolymerization from lignin with stable conditions and high yield . SA has been studied for its biological effects using a semisynthetic method, and the excellent performance of SA has indicated the application potential of this compound in thermoset polymer. − …”