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The objective of this research was to elucidate the biological effect of novel compounds derived from natural product of syringaldehyde through novel semi-synthetic method in order to investigate the physicochemical properties and biological activities by using DPPH and FRAP techniques and its antibacterial activities against Klebsiella spp., Pseudomonas aeruginosa, Bacillus cereus, and Staphylococcus aureus. Moreover, to examine its ability against breast cancer cell line (MCF-7). The results showed that the syringaldehyde hydrazonate copper complexes possessed the covalent bonds with square-planar structure. In terms of antioxidant DPPH activities, it was found that syringaldehyde hydrazone possessed high potency against DPPH free radicals, with respect to syringaldehyde hydrazonate copper complexes. On the other hand, all compounds possessed low reducing properties for changing Fe 3+ to Fe 2+ in FRAP technique. For antibacterial activities revealed that the ligand L1 and L5 possessed high effect on Pseudomonas aeruginosa, but for all copper complexes possessed high potent antibacterial susceptibility to four bacteria with concentration dependence. For anti-breast cancer cell line (MCF-7), it was found that all compounds possessed high potent anticancer susceptibility with low IC 50 , especially, compound exhibit highly potency effective is C5 (IC 50 9.75 μM). The tendency of anticancer effect from high to low was C5 > C2 > C1 > C4 > C3. Therefore, all synthetic compounds obtained from the present research possibly develop as the antibacterial drugs and the drugs for curing the diseases caused by free radicals, including breast cancer in metastatic phase. The most important feature of these drugs was the high specificity to the target and harmless to the normal cells.

The X-ray crystal structures of two ciprofloxacin compounds, viz. [Cu(cfH) 2 (Cl) 2 ] Á 2MeOH Á 6H 2 O (2) and [Cu(cfH)(phen)Cl]BF 4 Á 4H 2 O (3) are reported. Complex (2) has a distorted octahedral geometry, whereas for the nitrogen adduct (3) a distorted square-pyramidal geometry is seen. Significant enhancement in the antimycobacterial activity of the copper conjugates correlates with their copper redox couples (Cu 2+ /Cu + ) probably due to its relevance to intracellular accumulations and subsequent role in generating oxidative stress.

Many kinds of rice are processed in the processing of rice landraces. The farmers can earn more money by milling rice for milled rice, brown rice, and germinated brown rice. The aims of this study were to 1) investigate the chemical compositions, nutritional properties, and biological activities of antioxidants, and 2) to develop health supplements for the elderly together with village community. The native rice selected by the committee was categorized into three types: the Jib rice, the Black Fragrant rice (Oryza sativa), and the Dok-makam rice for analysis in this study. The results showed that the Dok-makam rice had the greatest protein, calcium, fiber, vitamins B1, sodium, amylose, and niacin. The most total fat, calcium, iron, zinc, and copper energy is provided by the Black Fragrant rice (Oryza sativa). The Jib rice contains the most carbohydrate, potassium, and magnesium. In terms of antioxidant capacity, it was found that the three native rice cultivars had enough antioxidant capacity. However, the Black Fragrant rice (Oryza sativa) had the highest antioxidant capacity followed by the Jib rice, and the Dok-makam rice.