Physicochemical properties, bioactive composition and antioxidant activities of noni fruit juices from different regions of cultivation

Kim, Ja-Min; Jo, Yong Jun; Hahn, Dongyup

doi:10.11002/kjfp.2017.24.7.1000

Cited by 7 publications

(3 citation statements)

References 22 publications

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“…This agrees with the results of Yan et al [17], who observed a high level of variation in seven phenolic constituents between eight brands of noni juice produced in China, Taiwan and Fiji. Similarly, Kim et al [31] observed that the processing methods had a significant impact on the total phenolic content and bioactivity of noni juice samples. Consequently, it is likely that this high level of variation in composition between brands can be attributed to the different starting materials and processes used in their manufacture.…”

Section: Quantitative Phenolic Profiling By Lc-msmentioning

confidence: 87%

An Analysis of Commercial Noni Juice: LC-MS/MS Phenolic Profiles and Cytotoxic Activity

2022

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Fermented juice from the noni tree (Morinda citrifolia) is a traditional medicinal product used by South Pacific Islanders to treat a wide range of ailments, including cancer, inflammation and obesity, as well as improving overall wellbeing. Many of its bioactive properties have been suggested to arise from the high antioxidant capacity and phenolic content found in the juice. However, there have been limited investigations into the phenolic profiles of noni juice produced locally in the Pacific. This study aimed to investigate the chemical composition and bioactive properties of noni juice. The first phase of this study used liquid chromatography with tandem mass spectrometry (LC-MS/MS) to characterise the phenolic composition of five brands of commercial noni juice produced in the South Pacific region. A total of 21 phenolic compounds were putatively identified, with the most abundant generally being rutin, 4-hydroxybenzoic acid and gentisic acid. Vastly differing phenolic profiles were found between the noni juice brands. Significant differences were also found in their antioxidant capacities and total phenolic contents. Of the three major phenolic compounds identified, gentisic acid showed the highest antioxidant activity (640% higher than Trolox). Additionally, the noni juice showed no significant anti-acetylcholinesterase activity and no to moderate cytotoxicity against two cancer cell lines (HeLa and HT29). These results indicate that the phytochemical profiles—and hence, the expected bioactive properties—are likely to vary significantly between different noni juice brands. Furthermore, the anti-cancer activity of non-concentrated noni juice appears to be relatively low.

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Section: Quantitative Phenolic Profiling By Lc-msmentioning

confidence: 87%

An Analysis of Commercial Noni Juice: LC-MS/MS Phenolic Profiles and Cytotoxic Activity

2022

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“…Upon the activation of macrophages by LPS, iNOS generates NO through the metabolism of L-arginine. While NO plays a crucial role in host defense and maintaining cell function, its overproduction in response to external stimuli can promote inflammatory reactions [41,42]. Inflammatory responses involve the secretion of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and inflammatory mediators like TNF-α, IL-6, and IL-1β [43].…”

Section: Discussionmentioning

confidence: 99%

Enhanced Anti-Inflammatory and Non-Alcoholic Fatty Liver Disease (NAFLD) Improvement Effects of Bacillus subtilis-Fermented Fagopyrum tataricum Gaertner

Park,

Kang,

Lee

2024

Fermentation

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In this study, we investigated the enhanced anti-inflammatory activity and the effects on non-alcoholic fatty liver disease (NAFLD) of fermented Fagopyrum tataricum (F. tataricum) Gaertner extract (FFT) through in vitro analysis. We utilized high-performance liquid chromatography (HPLC) to analyze the non-fermented F. tataricum Gaertner extract (NFT) and the marker components, rutin and quercetin in FFT, to confirm changes in composition due to fermentation. The anti-inflammatory activity of NFT and FFT was evaluated using a lipopolysaccharide (LPS)-induced RAW 264.7 cell inflammation model. Simultaneously, the NAFLD improvement effects were measured by evaluating lipid accumulation and the expression of lipid synthesis regulators in free fatty acid (FFA)-induced HepG2 cells. HPLC analysis confirmed an increase in rutin content after the fermentation of F. tataricum Gaertner. Upon treatment with NFT and FFT at a concentration of 400 μg/mL, LPS-induced nitric oxide (NO) production values in RAW 264.7 cells were reduced to 16.12 μM and 2.09 μM, respectively, indicating enhanced significant inhibition (p < 0.05) of NO production through fermentation. FFT demonstrated the significant inhibition (p < 0.05) of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) protein, and inflammatory cytokine mRNA expression through the nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways in LPS-induced RAW 264.7 cells. In FFA-induced HepG2 cells, FFT significant suppressed (p < 0.05) lipid accumulation and the expression of sterol regulatory element binding protein (SREBP)-1c, CCAAT/enhancer binding protein (C/EBP)α proteins, and acetyl-CoA carboxylase (ACC) mRNA. The results of this study suggest the potential utilization of FFT as a material for improving NAFLD.

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“…Noni ( Morinda citrifolia ) is a perennial plant belonging to the rubiaceous family and is a tropical fruit cultivated in Thailand, Indonesia, Hawaii, and Guam. It grows mainly in volcanic soils in coastal lowlands [ 1 ]. According to an Indonesian survey in 2014, 8,577,000 tons of noni were produced [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Feed Nutritional Value of Noni (Morinda citrifolia) Meal for Holstein Dairy Cows

Keum

Kim

Lee

et al. 2022

Animals

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In three consecutive studies, we evaluated the effects of noni (Morinda citrifolia) meal on rumen fermentation and degradation characteristics, production performance, physiological parameters, and milk fatty acid profile in Holstein dairy cows. In in vitro (first study) and in situ (second study) experiments, rumen fluids from two fistulated Holstein dairy cows were used. The concentration of noni meal added was 0 (control), 1, 3, 5, or 7% of the basal diet (DM basis). In the in situ experiment, wheat bran was used as a control. Triplicated bags were incubated for 0, 4, 8, 12, 24, 48, 72, or 96 h. In an in vivo experiment (third study), 38 Holstein cows (145 ± 87 days DIM; 1.8 ± 0.9 parity; 35.4 ± 6.3 kg/day milk yield) were equally assigned to the control and treatment groups (19 cows each). Basal feed and noni meal pellets (1.5% of total feed DM basis) were fed to the treatment group. The control group was also fed the basal feed and pellets containing 0% noni meal. There were no significant differences in in vitro dry matter digestibility, pH, total gas production (TGP), CH4, NH3-N, and volatile fatty acids (p > 0.05). In the in situ experiments, the crude protein (CP) rapidly soluble fraction ‘a’ (CP-a) was higher in noni meal than in wheat bran, and rumen degradable protein was also higher in noni meal than in wheat bran. In the in vivo experiments, when noni meal pellets were fed, there was no significant difference in milk yield and composition, but the triglyceride levels decreased (p < 0.05), the C18:1 fatty acid level increased (p < 0.05), and the C18:0 fatty acid level decreased (p < 0.05). Collectively, noni meal can be used as a feed ingredient up to 1.5% (total feed DM basis) in Holstein dairy cows and as feed supplementation to increase the C18:1 fatty acid level in milk.

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Physicochemical properties, bioactive composition and antioxidant activities of noni fruit juices from different regions of cultivation

Cited by 7 publications

References 22 publications

An Analysis of Commercial Noni Juice: LC-MS/MS Phenolic Profiles and Cytotoxic Activity

An Analysis of Commercial Noni Juice: LC-MS/MS Phenolic Profiles and Cytotoxic Activity

Enhanced Anti-Inflammatory and Non-Alcoholic Fatty Liver Disease (NAFLD) Improvement Effects of Bacillus subtilis-Fermented Fagopyrum tataricum Gaertner

Evaluation of the Feed Nutritional Value of Noni (Morinda citrifolia) Meal for Holstein Dairy Cows

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