Physicochemical Property and Antioxidative Activity of Hot-Water Extracts from Enzyme Hydrolysate of Astragalus membranaceus

권상철,; 최구희,; 황종현,; 이경행,

doi:10.3746/jkfn.2010.39.3.406

Cited by 15 publications

(4 citation statements)

References 10 publications

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“…Recently, there has been an increasing preference for foods that gratify palatability, nutrition, and physiologic functions to prevent aging and chronic diseases. Various studies are being made of functional foods and ingredients in academic and industrial circles ( Kwon et al, 2010 ). As the frequency of dine-out has increased all over the world, the consumption of fast foods and convenient meat products has increased rapidly, which implies a need for the production of functional fresh meat ( Zhang et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of Dietary Supplementation of the Combination of Gallic and Linoleic Acid in Thigh Meat of Broilers

Lee

Jung

Kim

et al. 2012

Asian Australas. J. Anim. Sci

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This study was performed to investigate the combined effect of dietary supplementation of gallic and linoleic acid (GL) on the antioxidative effect and quality of thigh meat from broilers. Broilers received 3 dietary treatments: i) commercial finisher diet (control), ii) 0.5% GL (gallic:linoleic acid = 1 M:1 M), and iii) 1.0% GL during the 22 to 36 d. The pH value of broiler thigh meat was increased by GL supplementation. Water holding capacity of the thigh meat was enhanced by the 1.0% dietary GL supplementation. Antioxidative effect (total phenolic content, DPPH radical scavenging activity, ABTS+ reducing activity, reducing power, and TBARS value) in the thigh from the broilers improved significantly with 1.0% GL. Linoleic acid and docosahexaenoic acids were higher in the broilers fed both levels of dietary GL. However, volatile basic nitrogen content and microbiological quality was not shown to be different between control and treated group. Results indicate that 1.0% dietary supplementation of GL can improve the antioxidant activity of broiler thigh meat and may enhance the meat quality.

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Section: Introductionmentioning

confidence: 99%

Effect of Dietary Supplementation of the Combination of Gallic and Linoleic Acid in Thigh Meat of Broilers

Lee

Jung

Kim

et al. 2012

Asian Australas. J. Anim. Sci

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“…Analisis penghambatan α-amilase dilakukan dengan menggunakan metode modifikasi dari Penelitian Kwon (Kwon et al, 2007). Sebanyak 50 µl sampel dicampur dengan 250 µl α-amilase dari babi pankreas kemudian ditambahkan 250 µl buffer sodium fosfat 0,02 M (pH 6,9).…”

Section: Metodeunclassified

Evaluation of the Anti-Diabetic Activity of Paliasa Leaf Ethanol Fraction (Kleinhovia hospita L) Through Inhibition of the Enzymes $\alpha$-Glucosidase and $\alpha$-Amylase

Rura,

Djabir,

Rahim

et al. 2023

JIKA

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Kleinhovia hospita has long been used to treat diseases, including diabetes mellitus. This study aimed to evaluate if the hypoglycemic effects of K. hospita extract and fractions were related to its inhibition on the activity of $\alpha$-amylase and $\alpha$-glycosidase enzymes. K. hospita leaves were extracted with 96% ethanol and then subjected to liquid-liquid partition using n-hexane, ethyl acetate, and water as solvents. The inhibitory capacity of ethanolic extract and its fractions were tested against $\alpha$-amylase and $\alpha$-glycosidase enzyme activity and compared to acarbose. The in vitro study revealed that the IC50 of ethanolic extract, hexane, ethyl acetate, and water fractions were 1496,8 µg/mL, 1266,7 µg/mL, 12577,5 µg/mL, and 5217,0 µg/mL, respectively, against alfa-amylase activity. Whereas, for $\alpha$-glycosidase activity, the IC50 values were 1341,2 µg/mL, 25470,0 µg/mL, 64450,0 µg/mL, and 1291,4 µg/mL, respectively. These values were markedly greater than those of the acarbose (7,4 and 5,5 µg/mL, respectively). From the research results, it was concluded that K. hospita leaf extract had a high IC50 value from K. hospita extracts and fractions, which indicated that the hypoglycemic effect of K. hospita was not related to the inhibition of the $\alpha$-amylase and $\alpha$-glycosidase enzymes.

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“…For centuries, some Asian countries have used Euonymus alatus (EA), an edible plant, for medicinal purposes in the treatment of several conditions, including cancer, hyperglycemia, menstrual discomfort, diabetic complications, and detoxification [ 1 , 2 ]. The Korean Food Code recognizes the young leaves of EA as registered food material.…”

Section: Introductionmentioning

confidence: 99%

“…Some components such as rutin, quercetin (QCT), and kaempferol extracted from Euonymus spp. have been reported to exhibit antioxidant activity [ 1 , 2 , 3 , 4 ]. Moreover, our previous studies demonstrated that the ethanolic extract of EA leaves can improve learning and memory impairment in scopolamine-treated mice and further promote Nrf2-mediated antioxidative activity in the hippocampal region [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Oral Administration of Euonymus alatus Leaf Extract Ameliorates Alzheimer’s Disease Phenotypes in 5xFAD Transgenic Mice

Kim,

Cho,

Jang

et al. 2024

Foods

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Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease and is frequently characterized by progressive and irreversible impairment of cognitive functions. However, its etiology remains poorly understood, limiting therapeutic interventions. Our previous study showed that the ethanol extract of Euonymus alatus leaves (EA) positively affected scopolamine-induced hypomnesia in the normal mouse model by promoting nuclear factor E2-related factor 2 (Nrf2) activation. Herein, we examined whether EA administration could ameliorate major AD phenotypes that are manifested in 5xFAD transgenic mice. Two-month-old mice were orally administered with EA at a dose of 50, 100, or 150 mg/kg body weight/day thrice a week for 14 weeks. We observed that EA administration improved behavioral deficits as assessed by the passive avoidance, Morris water maze, and Y-maze tasks; decreased the plasma levels of pro-inflammatory cytokines, including TNFα and IL-1β; decreased the protein expression levels of inflammatory mediators in the hippocampus; and attenuated histological damage and amyloid beta plaques in the hippocampal region of 5xFAD mouse brain. Interestingly, our data demonstrated that the effectiveness was partially attributed to quercetin, which was noted to be a component of EA. Hence, these findings suggest that a long-term administration of EA could alleviate AD symptoms and delay its progression.

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Physicochemical Property and Antioxidative Activity of Hot-Water Extracts from Enzyme Hydrolysate of Astragalus membranaceus

Cited by 15 publications

References 10 publications

Effect of Dietary Supplementation of the Combination of Gallic and Linoleic Acid in Thigh Meat of Broilers

Effect of Dietary Supplementation of the Combination of Gallic and Linoleic Acid in Thigh Meat of Broilers

Evaluation of the Anti-Diabetic Activity of Paliasa Leaf Ethanol Fraction (Kleinhovia hospita L) Through Inhibition of the Enzymes $\alpha$-Glucosidase and $\alpha$-Amylase

Oral Administration of Euonymus alatus Leaf Extract Ameliorates Alzheimer’s Disease Phenotypes in 5xFAD Transgenic Mice

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