Physics at the Munich Tandem Accelerator Laboratory

Dollinger, G.

doi:10.1080/10619127.2018.1427405

Cited by 22 publications

(21 citation statements)

References 60 publications

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“…3 − States -Two previously observed states at 3223.72(5) keV and 5358 (11) keV are firmly assigned as 3 − states from the work presented here. The state at 3224 keV was tentatively assigned as 3 ± by Ref.…”

Section: Experimental Assignmentssupporting

confidence: 72%

“…The work presented here confirms both of those assignments with measured energies of 4051.83(9) keV and 4549(4) keV, respectively. Three additional 3 − states are reported (9) 3324.57 (20) 3593.85 (16) 3611.77 (8) 3825.45 (16) d) e) 4130.5 (4) 3791.95 (7) 3873.51 (11) 4051.83 (11) 4525 (4) 4549 ( here, at energies of 3791.95 (6) (8) keV. Three of the states agree with the firm spin/parity assignment in the evaluated data, and the state at 3593.85 (16) keV removes the ambuguity of multiple assignments given in the evaluation.…”

Section: Experimental Assignmentsmentioning

confidence: 99%

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High-resolution ( p,t ) reaction measurements as spectroscopic tests of ab-initio theory in the mid- pf shell

et al. 2019

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Detailed spectroscopic measurements of excited states in 50 Cr and 62 Zn were performed using 24 MeV (p,t) transfer reactions on 52 Cr and 64 Zn, respectively. In total, forty-five states in 50 Cr and sixty-seven states in 62 Zn were observed up to excitation energies of 5.5 MeV, including several previously unobserved states. These experimental results are compared to ab-initio shell-model calculations using chiral effective field theory (χ-EFT) with the valence-space in-medium similarity renormalization group (VS-IMSRG) method. This comparison demonstrates good agreement in the level orderings with these new theoretical methods, albeit with a slight over binding in the calculations. This work is part of a continued push to benchmark ab-initio theoretical techniques to nuclear structure data in 0 + → 0 + superallowed Fermi β decay systems.

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Section: Experimental Assignmentssupporting

confidence: 72%

Section: Experimental Assignmentsmentioning

confidence: 99%

High-resolution ( p,t ) reaction measurements as spectroscopic tests of ab-initio theory in the mid- pf shell

et al. 2019

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“…In addition, it has proven to deliver dose rates in a wide range from 0.01 Gy/s to about 1,000 Gy/s. But the proton energy is too low, as the tandem Van-de-Graaff accelerator, at which SNAKE is installed, delivers protons only up to an energy of about 25 MeV [82]. This corresponds to a water equivalent range of 0.64 cm [79] and thus is not sufficient for the treatment of tumors in deeper organs in mice or rats.…”

Section: Review Of Facilities In Operationmentioning

confidence: 99%

“…We suggest the usage of an existing high energy tandem accelerator and installing a LINAC at one of its high-energy beam lines. The total beam time can be shared between the preclinical experiments and other multidisciplinary research activities, such as material analysis and modification, fundamental radiobiology research or high resolution accelerator mass spectroscopy [82]. This approach would also distribute the running costs of such a facility among several other research partners.…”

Section: Design Idea Of a Research Facility For Preclinical Experimentsmentioning

confidence: 99%

Preclinical Challenges in Proton Minibeam Radiotherapy: Physics and Biomedical Aspects

et al. 2020

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The concept of spatial fractionation in radiotherapy was developed for better sparing of normal tissue in the entrance channel of radiation. Spatial fractionation utilizing proton minibeam radiotherapy (pMBRT) promises to be advantageous compared to X-ray minibeams due to higher dose conformity at the tumor. Preclinical in vivo experiments conducted with pMBRT in mouse ear models or in rat brains support the prospects, but the research about the radiobiological mechanisms and the search for adequate application parameters delivering the most beneficial minibeam therapy is still in its infancy. Concerning preclinical research, we consider glioma, non-small cell lung cancer and hepatocellular carcinoma as the most promising targets and propose investigating the effects on healthy tissue, especially neuronal cells and abdominal organs. The experimental setups for preclinical pMBRT used so far follow different technological approaches, and experience technical limitations when addressing the current questions in the field. We review the crucial physics parameters necessary for proton minibeam production and link them to the technological challenges to be solved for providing an optimal research environment. We consider focusing of pencil or planar minibeams in a scanning approach superior compared to collimation due to less beam halos, higher peak-to-valley dose ratios and higher achievable dose rates. A possible solution to serve such a focusing system with a high-quality proton beam at all relevant energies is identified to be a 3 GHz radio-frequency linear accelerator. We propose using a 16 MeV proton beam from an existing tandem accelerator injected into a linear post-accelerator, boosted up to 70 MeV, and finally delivered to an imaging and positioning end-station suitable for small animal irradiation. Ion-optical simulations show that this combination can generate focused proton minibeams with sizes down to 0.1 mm at 18 nA mean proton current - sufficient for all relevant preclinical experiments. This technology is expected to offer powerful and versatile tools for unleashing structured and advanced preclinical pMBRT studies at the limits and also has the potential to enable a next step into precision tumor therapy.

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“…It consists of two Side Coupled Drift Tube Linac (SCDTL) structures orignially designed from ENEA for the TOP-IMPLART project [ 20 ] and 4 Coupled Cavity Linac (CCL) structures. The advantage using an existing tandem accelerator (like the one situated at the Maier Leibnitz Laboratory in Garching [ 21 ]) as injector is the reduced costs compared to the full front-end linac system [ 19 , 20 ], since the radio-frequency quadrupole (RFQ) and the first modules of the linac can be omitted. Additionally, the tandem accelerator is perfectly suited to generate a bright and high intensity proton beam and can be used for other applications (e.g.…”

Section: Introductionmentioning

confidence: 99%

Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility

et al. 2021

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To demonstrate the large potential of proton minibeam radiotherapy (pMBRT) as a new method to treat tumor diseases, a preclinical proton minibeam radiation facility was designed. It is based on a tandem Van-de-Graaff accelerator providing a 16 MeV proton beam and a 3 GHz linac post-accelerator (designs: AVO-ADAM S.A, Geneva, Switzerland and ENEA, Frascati, Italy). To enhance the transmission of the tandem beam through the post-accelerator by a factor of 3, two drift tube buncher units were designed and constructed: A brazed 5-gap structure (adapted SCDTL tank of the TOP-IMPLART project (ENEA)) and a non-brazed low budget 4-gap structure. Both are made of copper. The performance of the two differently manufactured units was evaluated using a 16 MeV tandem accelerator beam and a Q3D magnetic spectrograph. Both buncher units achieve the required summed voltage amplitude of 42 kV and amplitude stability at a power feed of less than 800 W.

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Physics at the Munich Tandem Accelerator Laboratory

Cited by 22 publications

References 60 publications

High-resolution ( p,t ) reaction measurements as spectroscopic tests of ab-initio theory in the mid- pf shell

High-resolution ( p,t ) reaction measurements as spectroscopic tests of ab-initio theory in the mid- pf shell

Preclinical Challenges in Proton Minibeam Radiotherapy: Physics and Biomedical Aspects

Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility

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