1996
DOI: 10.1055/s-2008-1067974
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Physiologic Basis of Ovulation Induction

Abstract: Optimal regimens for ovulation induction depend on a sound, fundamental understanding of the physiology of ovulation. This chapter will review the endocrinology of folliculogenesis, with particular emphasis on the signaling pathways activated by FSH and LH. Important new information regarding the molecular mechanisms of signal transduction and the biologic responses that are produced will also be presented. Ultimately, a clearer understanding of mechanisms regulating the selection and promotion of the dominant… Show more

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Cited by 24 publications
(8 citation statements)
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“…The production of estradiol in the human ovary results from a cooperation of teca and granulosa cells (15); in clinical practice, serum estradiol is an established variable to detect multiple follicular development.…”
Section: Discussionmentioning
confidence: 99%
“…The production of estradiol in the human ovary results from a cooperation of teca and granulosa cells (15); in clinical practice, serum estradiol is an established variable to detect multiple follicular development.…”
Section: Discussionmentioning
confidence: 99%
“…On the basis of their morphology, follicles were subdivided in three categories, with category 1 follicles showing the best morphologic features. On Day 0, only category 1 follicles were selected, but follicle categories were reassigned on evaluation Days 1,2,4,7,or 10. Although 67% of the follicles survived 10 days of IVC, the number of follicles exhibiting a normal morphology decreased significantly from Day 7 onward and the apoptotic index increased significantly from Day 10.…”
Section: Introductionmentioning
confidence: 99%
“…However, the number of primordial follicles is still believed to be limited in most species, despite several reports on oogenesis after birth in mice and prosimian primates [6][7][8][9]. In vivo, from the first ovulatory cycle until menopause, only a small fraction of primordial follicles will ultimately reach the preovulatory stage, whereas the remaining follicles will degrade by atresia [10]. Although cryopreservation of early preantral ovarian follicles in situ can play a crucial role in restoring female fertility after a successful radiotherapy and/or chemotherapy [11][12][13][14][15], subsequent ovarian tissue autotransplantation bears the risk of reintroducing cancer cells [16].…”
Section: Introductionmentioning
confidence: 99%
“…The preovulatory surge of luteinizing hormone (LH) induces a series of ovulatory changes culminating in the rupture of the follicle in mammals (Richards and Hedin, 1988;Irianni and Hodgen, 1992;Erickson, 1996). This process has been compared to an inflammatory response, in which the key regulators appear to be prostaglandins (PGs), plasminogen activators, steroids, and collagenase (Espey, 1980;Irianni and Hodgen, 1992).…”
mentioning
confidence: 99%