Physiologic Reactions After Proton Beam Therapy in Patients With Prostate Cancer: Significance of Urinary Autoactivation

Shimizu, Masakazu; Sasaki, Ryohei; Miyawaki, Daisuke; Nishimura, Hideki; Demizu, Yusuke; Akagi, Takashi; Suga, Daisaku; Sakamoto, Hiroo; Murakami, Masao; Sugimura, Kazuro; Hishikawa, Yoshio

doi:10.1016/j.ijrobp.2009.02.085

Cited by 5 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We evaluated the irradiated area by autoactivation imaging using positron-emission tomography/computed tomography (PET/CT) on the first day of PBT [ 41 ]. Autoactivation PET is suboptimal for evaluating irradiated dose or position in detail, thus we used this image for rough irradiated position confirmation.…”

Section: Methodsmentioning

confidence: 99%

Proton Beam Therapy without Fiducial Markers Using Four-Dimensional CT Planning for Large Hepatocellular Carcinomas

Shibata

Takamatsu

Yamamoto

et al. 2018

Cancers

View full text Add to dashboard Cite

We evaluated the effectiveness and toxicity of proton beam therapy (PBT) for hepatocellular carcinomas (HCC) >5 cm without fiducial markers using four-dimensional CT (4D-CT) planning. The subjects were 29 patients treated at our hospital between March 2011 and March 2015. The median total dose was 76 Cobalt Gray Equivalents (CGE) in 20 fractions (range; 66–80.5 CGE in 10–32 fractions). Therapy was delivered with end-expiratory phase gating. An internal target volume (ITV) margin was added through the analysis of respiratory movement with 4D-CT. Patient age ranged from 38 to 87 years (median, 71 years). Twenty-four patients were Child–Pugh class A and five patients were class B. Tumor size ranged from 5.0 to 13.9 cm (median, 6.9 cm). The follow-up period ranged from 2 to 72 months (median; 27 months). All patients completed PBT according to the treatment protocol without grade 4 (CTCAE v4.03 (draft v5.0)) or higher adverse effects. The two-year local tumor control (LTC), progression-free survival (PFS), and overall survival (OS) rates were 95%, 22%, and 61%, respectively. The LTC was not inferior to that of previous reports using fiducial markers. Respiratory-gated PBT with 4D-CT planning without fiducial markers is a less invasive and equally effective treatment for large HCCs as PBT with fiducial markers.

show abstract

Section: Methodsmentioning

confidence: 99%

Proton Beam Therapy without Fiducial Markers Using Four-Dimensional CT Planning for Large Hepatocellular Carcinomas

Shibata

Takamatsu

Yamamoto

et al. 2018

Cancers

View full text Add to dashboard Cite

show abstract

“…Several researchers have investigated whether AAPET is useful for treatment verification with proton beam therapy and Cion RT and they have concluded that AAPET verification is useful and reliable (28,29). However, owing to the large size of the instrumentation, current research with AAPET is mainly conducted with PET installed in a room separate from the irradiation room.…”

Section: Discussionmentioning

confidence: 99%

“…However, AAPET has the disadvantage of large instrument size; thus, it is difficult to install an AAPET device in the treatment room, requiring patients to be transported from the treatment room for the imaging. This generates a time lag between the C-ion irradiation and AAPET imaging, which allows transport of the activated elements with annihilation gammarays to unirradiated tissues via biofluids (29) and results in blurring of the obtained image. Therefore, it is not advisable to use AAPET for C-ion RT verification, unless the device is sufficiently downsized for in-room installation.…”

Section: Introductionmentioning

confidence: 99%

Use of a Si/CdTe Compton Camera for In vivo Real-Time Monitoring of Annihilation Gamma Rays Generated by Carbon Ion Beam Irradiation

et al. 2020

View full text Add to dashboard Cite

The application of annihilation gamma-ray monitoring to the adaptive therapy of carbon ion radiotherapy (C-ion RT) requires identification of the peak intensity position and confirmation of activated elements with annihilation gamma-rays generated at the C-ion-irradiated site from those transported to unirradiated sites. Real-time monitoring of C-ion-induced annihilation gamma-rays was implemented using a Compton camera in a mouse model. An adult C57BL/6 mouse was anesthetized, and C-ion beams were directed into the abdomen at 1 × 10 9 particles/s for 20 s. The 511 keV annihilation gamma-rays, generated by the interaction between the irradiated C-ion beam and the target mouse, were detected using a silicon/cadmium telluride (Si/CdTe) Compton camera for 20 min immediately after irradiation. The irradiated site and the peak intensity position of 511 keV gamma emissions due to C-ion beam irradiation on a mouse were observed at the abdomen of the mouse by developing Compton images. Moreover, the positron emitter transport was observed by evaluating the range of gamma-ray emission after the C-ion beam irradiation on the mouse. Our data suggest that by confirming the peak intensity and beam range of C-ion RT with Si/CdTe-based Compton camera, it would be possible to reduce the intra-fractional and inter-fractional dose distribution degradation. Therefore, the results of this study would contribute to the future development of adaptive therapy with C-ion RT for humans.

show abstract

“…In the present study, we evaluated the target and GI tract by autoactivation imaging using positron emission tomography–CT. The data acquisition started 5 to 10 minutes after proton beam irradiation to assess the irradiated area on the first day of PBT [ 36 ]. Differences in the position or shape and total dose of the target or GI tract were evaluated by rigid fusion techniques using MIM Maestro.…”

Section: Methodsmentioning

confidence: 99%

Respiratory-Gated Proton Beam Therapy for Hepatocellular Carcinoma Adjacent to the Gastrointestinal Tract without Fiducial Markers

Mizuhata

Takamatsu

Shibata

et al. 2018

Cancers

View full text Add to dashboard Cite

The efficacy of proton beam therapy (PBT) for hepatocellular carcinoma (HCC) has been reported, but insertion of fiducial markers in the liver is usually required. We evaluated the efficacy and toxicity of respiratory-gated PBT without fiducial markers for HCC located within 2 cm of the gastrointestinal tract. From March 2011 to December 2015 at our institution, 40 patients were evaluated (median age, 72 years; range, 38–87 years). All patients underwent PBT at a dose of 60 to 80 cobalt gray equivalents (CGE) in 20 to 38 fractions. The median follow-up period was 19.9 months (range, 1.2–72.3 months). The median tumor size was 36.5 mm (range, 11–124 mm). Kaplan–Meier estimates of the 2-year overall survival, progression-free survival, and local tumor control rates were 76%, 60%, and 94%, respectively. One patient (2.5%) developed a grade 3 gastric ulcer and one (2.5%) developed grade 3 ascites retention; none of the remaining patients developed grade >3 toxicities (National Cancer Institute Common Terminology Criteria for Adverse Events ver. 4.0.). This study indicates that PBT without fiducial markers achieves good local control without severe treatment-related toxicity of the gastrointestinal tract for HCC located within 2 cm of the gastrointestinal tract.

show abstract

Physiologic Reactions After Proton Beam Therapy in Patients With Prostate Cancer: Significance of Urinary Autoactivation

Cited by 5 publications

References 16 publications

Proton Beam Therapy without Fiducial Markers Using Four-Dimensional CT Planning for Large Hepatocellular Carcinomas

Proton Beam Therapy without Fiducial Markers Using Four-Dimensional CT Planning for Large Hepatocellular Carcinomas

Use of a Si/CdTe Compton Camera for In vivo Real-Time Monitoring of Annihilation Gamma Rays Generated by Carbon Ion Beam Irradiation

Respiratory-Gated Proton Beam Therapy for Hepatocellular Carcinoma Adjacent to the Gastrointestinal Tract without Fiducial Markers

Contact Info

Product

Resources

About