Physiological activity of streptothricin antibiotics.

The Biological Function of the Bacterial Isochorismatase-Like Hydrolase SttH

“…Streptothricins (STs) produced by Streptomyces strains are broad-spectrum antibiotics effective against both prokaryotes and eukaryotes. [1][2][3][4][5][6][7][8] All STs consist of a carbamoylated D-gulosamine to which a homopolymer of 1 to 7 -lysine residues and a streptolidine lactam group, an amide form of the unusual amino acid streptolidine, are attached ( Fig. 1).…”

Isolation of Two Streptothricin-like Antibiotics, Nos. 6241-A and B, as Inhibitors of de novo Starch Synthesis and Their Herbicidal Activity

“…4 ) Takemoto et ai. 5 ) and Kubo et ai. 6 ) have reported the plant growth inhibitory activity of racemomycin D, which contains four moles of fJ-Iysine.…”

Selective toxicity alteration of a highly toxic antibiotic by an enzyme catalyzing antibiotic modification

“…All STs consist of a carbamoylated D-gulosamine to which the -lysine homopolymer (1 to 7 residues) and the amide form of the unusual amino acid ''streptolidine lactam'' are attached. STs inhibit protein biosynthesis in prokaryotic cells; in addition, they strongly inhibit the growth of eukaryotes such as yeasts (Goldstein & McCusker, 1999;Hentges et al, 2005;Shen et al, 2005), fungi (Idnurm et al, 2004), protozoa (Joshi et al, 1995), insects (Takemoto et al, 1980) and plants (Chamberlain et al, 1994). Therefore, STs are used as effective selective agents for recombinant DNA work in some of these organisms.…”