Physiological Activity of the Glycyrrhiza uralensis Extracts as a Cosmetic Product

Abstract

Purpose: The aim of this study was to investigate the biological and cosmetic properties and the industrial value of the Glycyrrhiza uralensis (G. uralensis) extracts. Methods: The protective effects and anti-inflammatory efficacy of G. uralensis in HaCaT cells and RAW 264.7 cells against anti-oxidation and oxidative stress were analyzed, and the secretion of β-hexosaminidase, which plays a leading role in easing allergic symptoms, was measured. Moreover, anti-bacterial activity on human skin pathogens was measured. Ethanol (70%) and hot water extraction were performed to make the extracts from domestically grown G. uralensis. Results: The comparison revealed that the 70% ethanol extracts were excellent in as antioxidants. Results of the cell experiment using the G. uralensis extracts showed that there was no significant cytotoxicity in HaCaT, RAW 264.7, or RBL-2H3 cells. In HaCaT cells, there was a 28% increase in the protective effects against oxidative stress caused by hydrogen peroxide (H 2 O 2) using a concentration of 100 μg/mL of the 70% ethanol extracts. The anti-inflammatory efficacy of the G. uralensis extracts on RAW 264.7 cells was checked, and it was found that the production of nitric oxide (NO) was inhibited, even low concentrations. The secretion of β-hexosaminidase was also measured, and it was found that G. uralensis and the ethanol and hot water extracts inhibited the degranulation of immune cells, depending on concentrations levels. It was confirmed that G. uralensis 's antibacterial activity was even effective against Staphylococcus aureus (S. aureus), Staphylococcus epidermidis (S. epidermidis), and Propionibacterium acnes (P. acnes) depending on the concentrations of used. Conclusion: Based on the findings of this study, the G. uralensis extracts are recommended as ingredients for sensitive skin cosmetics. A systematic study on verifying the efficacy of the G. uralensis extracts is further required through tests on humans and animals in order to determine the possibility of its clinical use.

Comparison of halitosis according to herbal mouthwash containing Glycyrrhiza uralensis extract and saline mouthwash: A randomized, double‐blind, placebo‐controlled study

“…The methyl mercaptan reduction effect of Cheonggugamrosu , a mixture of dried clove buds, fruit of S. chinensis and G. uralensis , was 82.28%, while gargling mint reduced halitosis by 46.77% 25 . G. uralensis is widely used as a medicinal herb in Korea, China and Japan, and has been identified with anti‐allergic, anti‐inflammatory, 26 cell protection 27 and anticancer effects 28 . In addition, with regards to its effect on oral disease, the use of mouthwash containing G. uralensis is gaining attention as its anticaries 29 and antibacterial effects to bacterium‐causing periodontal disorders were reported 30 .…”

Comparison between the Biological Activities of Leaf and Flower Extracts of Osmanthus fragrans var. aurantiacus and Osmanthus asiaticus Lour. var. fragrans

“…화장품 원료 개발을 위한 생리활성 국내 연구는 천년초 열매 추출 물 (Ha & You, 2016), 파슬리 추출물 (Choi & Moon, 2017), 감초 추 출물 (Kim & Ryu, 2017), 발아 귀리 추출물 (Hwang et al, 2020), 커 피나무 잎 추출물 (Im & Doo, 2021) 등이 연구되었다.…”

Anti-oxidative and Anti-inflammatory Effects of Codonopsis lanceolata Skin Extracts

“…. 염증반응은 생체에 이물질이 감 염 또는 침입하였거나 물리 화학적 손상을 입었을 때 이를 방 어하기 위한 국소적 현상이지만, 과잉의 생체 방어 반응은 염 증 국소 주위에 있는 정상조직을 손상시켜 염증질환을 일으킨 다 (Kim & Ryu, 2017;Park et al, 2011 (Park & Kang, 2016). 생체 내 염증을 촉진하는 효소로는 cyclooxygenase-2 (COX-2)와 lipoxygenase (LOX)가 잘 알 려져 있으며, 이들 효소를 저해하는 물질은 염증성 질환을 저해 하는 항염증제로서 개발 가능성이 높다 (Kim & Jeong, 2014 (Kim & Chung, 1975;Kim et al, 2010a).…”