Physiological and haematological parameters of bitches affected with pyometra

Jena, Basanti; Rao, K. Sadasiva; Reddy, K. C. S.; Raghavender, K.B.P.

doi:10.5455/vetworld.2013.409-412

Cited by 6 publications

(6 citation statements)

References 3 publications

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“…Fever is an inconsistent condition usually related to bacterial infection, uterine inflammation, and septicemia [11,18]. In this study, pyometra did not influence fever and agreed with previous studies [18,22,23]. The influence of pyometra on other clinical signs (e.g., anorexia, depression, vomit, PU, PD, and abdominal pain) varied, which was similar to previous studies [18,24,25].…”

Section: Discussionsupporting

confidence: 92%

First report on clinical aspects, blood profiles, bacterial isolation, antimicrobial susceptibility, and histopathology in canine pyometra in Thailand

Lansubsakul

Sirinarumitr

et al. 2022

Vet World

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Background and Aim: Canine pyometra, either the closed (closed pyometra [CP]) or open (open pyometra [OP]) cervix type, is a frequent uterine disease in intact old age bitches. Therefore, early diagnosis and appropriate medical and surgical treatments are crucial to avoid the life-threatening condition in these bitches. This study aimed to investigate clinical alterations, blood parameters, causative bacteria, antimicrobial susceptibility, and uterine histopathology obtained during aseptic surgical treatment on bitches with pyometra. Materials and Methods: Sixty bitches of various breeds and ages with presumptive pyometra diagnoses were included in the study. The diagnoses were based on history, clinical examination, blood parameters, radiography, and ultrasonography. All pyometra bitches were ovariohysterectomized as an emergency surgical treatment. In addition, uterine content and tissues were submitted for bacterial isolation, antimicrobial susceptibility, and uterine histopathological analysis. Results: Except for abdominal CP distention, no specific clinical signs were linked to the pyometra type. The mean values of total white blood cell count (WBC) and plasma protein were predominantly raised in pyometra bitches regarding hematological parameters. Leukocytosis was found in both types; however, the WBC in CP was markedly higher than in OP. The mean value of blood urea nitrogen increased in the CP group. Klebsiella pneumoniae and Escherichia coli were the most frequent causative bacteria isolated in CP and OP, respectively. All isolated bacteria were 100% susceptible to imipenem, meropenem, and carbapenem. Marbofloxacin was the second most effective drug against isolated bacteria from both groups. Uncomplicated cystic endometrial hyperplasia (CEH) was not presented in the CP group. CEH and chronic endometritis (type IV), the most severe uterine histopathological changes, were discovered in the CP and OP. Conclusion: The CP and OP groups presented leukocytosis, increased plasma protein, and CEH and chronic endometritis. Depression, abdominal distention, and enlarged uterine size were the major characteristics of the CP group. Furthermore, abdominal distension is presented in other abnormalities in clinical practices, providing a differential diagnosis. Drugs in the carbapenem group were the most effective against isolated bacteria; however, they are not routinely used due to bacterial resistance concerns. Thus, marbofloxacin was recommended as an alternative medical treatment because it is convenient to manage by both oral and injection routes.

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Section: Discussionsupporting

confidence: 92%

First report on clinical aspects, blood profiles, bacterial isolation, antimicrobial susceptibility, and histopathology in canine pyometra in Thailand

Lansubsakul

Sirinarumitr

et al. 2022

Vet World

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“…In our study, two segmented neutrophils were found significantly lower in PG before and after OVH. Lymphopenia, eosinophilia, and monocytosis were seen in PG before OVH and this result within the accordance with a similar study [37] . Different breeds of dogs that have different cytokines, hormones and humoral factors, and many different breeds were included in our study and in our opinion this heterogeneity might affected some of our results.…”

Section: Discussionsupporting

confidence: 81%

Köpeklerde Pyometranın Bazı Oksidatif Stres Parametreleri, İnflamatorik Mediyatörler ve Nötrofil Segmentasyonu Üzerine Etkileri

Karabulut¹,

Ateş²,

Yılmaz³

et al. 2016

Kafkas Univ Vet Fak Derg

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“…Most bacteria isolated from uterine content are gram negative bacteria that release lipopolysaccharidestructured endotoxin from their cell walls [1,3,5] . Multiple organ failure due to sepsis [6] and death may be observed in this disease [7][8][9] . Previous studies have shown that the mortality rate caused by pyometra is about 4-26% [7,9,10] .…”

Section: Introductionmentioning

confidence: 99%

Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri

Demırel¹,

Vural²,

Vural³

et al. 2018

Kafkas Univ Vet Fak Derg

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The object of this study was to compare the histopathologic change in uterus as well as the findings of clinical and bacteriological of twentyfour bitches with pyometra. Uterine lesions were grouped as acute endometritis, subacute endometritis, acute metritis, subacute metritis. Complete blood-count, blood biochemical parameters and toxin levels were determined. Only alkaline phosphatase levels were significantly different between all groups (P<0.01). Blood endotoxin level was different between the acute and subacute endometritis groups (P<0.01), and subacute endometritis and acute metritis groups (P<0.01). All bitches in the subacute endometritis group recovered. Three bitches in the acute endometritis group, two bitches in the acute metritis group and one bitch in the subacute metritis group died. The blood endotoxin level was determined to be quite high in the dead bitches. There was a difference in the levels of blood urea nitrogen (P<0.05), creatinine (P<0.01), and toxin (P<0.0001) between the dead and surviving bitches. In conclusion, the prognosis of pyometra may be recovered in bitches diagnosed with subacute endometritis associated with low levels of circulating endotoxin. The endotoxemic bitches that have blood endotoxin level above 0.96 EU/mL along with significantly increased alkaline phosphatase, blood urea nitrogen, and creatinine concentration would likely end up with a mortality outcome for acute endometritis, acute metritis, or subacute metritis. These parameters may serve as good prognostic markers in bitches with pyometra. Keywords: Bacteriology, Bitch, Histopathology, Prognosis, Pyometra Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri ÖzBu çalışmanın amacı, pyometralı yirmi dört köpeğin uteruslarındaki histopatolojik değişikliklerin karşılaştırılmasıdır. Uterus lezyonları akut endometritis, subakut endometritis, akut metritis, subakut metritis olarak gruplandırıldı. Tam kan sayımı, kan biyokimyasal parametreler ve toksin seviyeleri belirlendi. Tüm gruplar arasındaki farklılık sadece alkalen fosfotaz seviyesinde önemliydi (P<0.01). Kan endotoksin seviyesi, akut ve subakut endometritis grupları (P<0.01) ile subakut endometritis ve akut metritis grupları (P<0.01) arasında farklıydı. Subakut endometritis grubundaki tüm köpekler iyileşti. Akut endometritis grubunda üç köpek, akut metritis grubunda iki köpek ve subakut metritis grubunda ise bir köpek öldü. Kan endotoksin seviyesinin ölen köpeklerde oldukça yüksek seviyede olduğu belirlendi. Ölen ve yaşayan köpekler arasında kan üre nitrojen (P<0.05), kreatinin (P<0.01) ve toksin (P<0.0001) seviyelerinin farklı olduğu görüldü. Sonuç olarak, dolaşımdaki endotoksinin düşük seviyesi ile ilişkili olarak subakut endometritis tanısı konulan köpeklerde pyometranın prognozunun iyileştirilebileceği düşünüldü. Yüksek seviyede alkalen fosfotaz, kan üre azotu ve kreatinin konsantrasyonu ile birlikte 0.96 EU/mL'nin üstündeki kan endotoksin düzeyine sahip endotoksemik köpeklerde akut endometritis, akut metritis veya ...

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Physiological and haematological parameters of bitches affected with pyometra

Cited by 6 publications

References 3 publications

First report on clinical aspects, blood profiles, bacterial isolation, antimicrobial susceptibility, and histopathology in canine pyometra in Thailand

First report on clinical aspects, blood profiles, bacterial isolation, antimicrobial susceptibility, and histopathology in canine pyometra in Thailand

Köpeklerde Pyometranın Bazı Oksidatif Stres Parametreleri, İnflamatorik Mediyatörler ve Nötrofil Segmentasyonu Üzerine Etkileri

Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri

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