Physiological and microvascular responses to hemoglobin concentration-targeted hemolytic anemia in rats

Nugent, William H.; Carr, Danuel A; Macko, Antoni R.; Song, Bjorn K.

doi:10.1152/japplphysiol.00767.2019

Cited by 3 publications

(3 citation statements)

References 45 publications

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“… 29 , 30 Anemia can also induce oxidative stress through endothelial damage. 31 , 32 In our study, decrease in Hb level was strongly associated with the decrease in cognitive function of patients in the CI group as compared to patients without cognitive impairment. Pearson correlation analysis in our study showed that in ischemic stroke patients, the serum APN and Hb levels were positively correlated with MOCA scores, indicating a linear relationship between serum APN and Hb levels and vascular cognitive impairment severity.…”

Section: Discussionsupporting

confidence: 52%

Predictive value of serum adiponectin and hemoglobin levels for vascular cognitive impairment in ischemic stroke patients

Li¹,

Zhu²,

Meng³

et al. 2022

Pak J Med Sci

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Objectives: To investigate the potential predictive value of serum adiponectin (APN) and hemoglobin (Hb) levels for the occurrence of vascular cognitive impairment in ischemic stroke patients. Methods: Eighty ischemic stroke patients, admitted to our hospital between June 2019 and November 2020, were retrospectively divided into no cognitive impairment (NCI) group (n=43) and cognitive impairment (CI) group (n=37) based on Montreal Cognitive Assessment (MoCA) scale scoring at three months follow-up. ELISA was used to assess serum Hb and APN levels and receiver operating characteristic (ROC) curves were created to evaluate correlation. Results: Serum APN and Hb levels were lower in the vascular cognitive impairment group compared to non-impaired counterparts. Pearson correlation analysis showed that both APN and Hb levels were positively correlated with MoCA scores. Area under curve analysis indicated predictive value for serum APN and Hb for predicting cognitive impairment in ischemic stroke patients. Conclusion: Serum APN and Hb levels in ischemic stroke patients have value for predicting vascular cognitive impairment and may be suitable for helping dictate treatment planning. doi: https://doi.org/10.12669/pjms.38.3.5204 How to cite this:Li Z, Zhu M, Meng C, Lin H, Huang L. Predictive value of serum adiponectin and hemoglobin levels for vascular cognitive impairment in ischemic stroke patients. Pak J Med Sci. 2022;38(3):705-710. doi: https://doi.org/10.12669/pjms.38.3.5204 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 52%

Predictive value of serum adiponectin and hemoglobin levels for vascular cognitive impairment in ischemic stroke patients

Li¹,

Zhu²,

Meng³

et al. 2022

Pak J Med Sci

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“…The clinically defined transfusion trigger in uncomplicated anemia is a hemoglobin level of 7 g/dL (18), which neither group reached, but comorbidities (e.g., hypovolemic shock), can elevate the transfusion trigger into the WB tHb range seen in this study. VS -101’s formulation was both effective in preventing shock from the aggressive ET and maintaining P ISF o 2 at BL levels for over 180 min, while LRS, despite a similar WB tHb, was permissive of shock and then failed to stabilize P ISF o 2 at a new steady state as seen in models of hemolytic anemia (14).…”

Section: Discussionmentioning

confidence: 99%

“…Measurements of the partial pressure of oxygen in interstitial fluid (P ISF O 2 ) of the exteriorized spinotrapezius muscle and the technical setup have been previously described in depth (13)(14)(15). Briefly, a phosphor (Oxyphore R0; Frontier Scientific, Newark, DE) bound to albumin (Bovine Serum Albumin; Sigma Aldrich, St Louis, MO) was topically diffused into the spinotrapezius' interstitium.…”

Section: Phosphorescence Quenching Microscopymentioning

confidence: 99%

Exchange Transfusion With vs-101: A New Pegylated-Hb Designed to Restore Perfusion and Increase O2 Carrying Capacity

Nugent,

Sheppard,

Vandegriff

et al. 2023

Shock

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Blood products are the current standard for resuscitation of hemorrhagic shock. However, logistical constraints of perishable blood limit availability and pre-hospital use meaning alternatives that provide blood-like responses remain an area of active investigation and development. VS-101 is a new PEGylated human hemoglobin-based oxygen carrier that avoids the logistical hurdles of traditional blood transfusion. This study sought to determine the safety and ability of VS-101 to maintain circulatory function and capillary oxygen delivery in a severe (50%) exchange transfusion (ET) model. Anesthetized, male Sprague Dawley rats were prepared for cardiovascular monitoring and phosphorescence quenching microscopy of interstitial fluid oxygen tension (PISFO2) in the spinotrapezius muscle. 50% isovolemic ET of estimated total blood volume with either Lactated Ringer’s (LRS; N = 8) or VS-101 (N = 8) at 1 mL/kg/min was performed, and animals were observed for 240 min. VS-101 maintained PISFO2 at baseline (BL) with a transient 18 ± 4 mmHg decrease (p < 0.05) in mean arterial pressure (MAP). In contrast, ET with LRS decreased PISFO2 by ~50% (p < 0.05) and MAP by 74 ± 10 mmHg (p < 0.05). All VS-101 animals survived 240 min, the experimental endpoint, while 100% of LRS animals expired by 142 min. VS-101 animals maintained normal tissue oxygenation through 210 min, decreasing by 25% (p < 0.05 vs. BL) thereafter, likely from VS-101 vascular clearance. No arteriolar vasoconstriction was observed following VS-101 treatment. In this model of severe exchange transfusion, VS-101 effectively maintained blood pressure, perfusion, and PISFO2 with no vasoconstrictive effects. Further elucidation of these beneficial resuscitation effects of VS-101 is warranted to support future clinical trials.

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Oxygenation through oral Ox66 in a two-hit rodent model of respiratory distress

Song,

Carr,

Bruce

et al. 2024

Artificial Cells, Nanomedicine, and Biotechnology

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Physiological and microvascular responses to hemoglobin concentration-targeted hemolytic anemia in rats

Abstract: Early, chronic compensation to severe hemolytic anemia is vascular, switching to cardiopulmonary support as hemoglobin levels decline. Oxygen delivery does not correlate with serum lactate level until total hemoglobin is reduced by 75%.

Cited by 3 publications

References 45 publications

Predictive value of serum adiponectin and hemoglobin levels for vascular cognitive impairment in ischemic stroke patients

Predictive value of serum adiponectin and hemoglobin levels for vascular cognitive impairment in ischemic stroke patients

Exchange Transfusion With vs-101: A New Pegylated-Hb Designed to Restore Perfusion and Increase O2 Carrying Capacity

Oxygenation through oral Ox66 in a two-hit rodent model of respiratory distress

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