Physiological basis: how NREM sleep components can promote and REM sleep components can suppress seizure discharge propagation

Shouse, Margaret N.; Farber, Paul R.; Staba, Richard J.

doi:10.1016/s1388-2457(00)00397-7

Cited by 113 publications

(93 citation statements)

References 26 publications

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“…These notions emerge, in part, from seminal studies in the cat penicillin and amygdala kindling models of epilepsy by Shouse (1987) and Shouse et al (1989Shouse et al ( , 1990Shouse et al ( , 2000 in which a majority of seizures emerged from NREM and few seizures emerged from REM, attributed to differences in cortical synchrony between these states (Shouse et al, 1989(Shouse et al, , 2000but see Sinha, 2011). In contrast, the interpretation that hippocampal theta is antiepileptic derives from studies of the effect of induced medial-septum theta rhythm on ongoing status epilepticus (Miller et al, 1994), modulation of electrical stimulus induced afterdischarge threshold (Kumar and Raju, 2001) or modulation of interictal epileptiform discharge frequency (Colom et al, 2006;Kitchigina and Butuzova, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…There is an acknowledged relationship between state of vigilance (SOV), also known as sleep-wake state, and seizure onset in various human (Bazil and Walczak, 1997;Crespel et al, 2000;for review, see Dinner, 2002;Minecan et al, 2002;Malow, 2007;Kothare and Zarowki, 2011;Sinha, 2011) and experimental (Quigg et al, 2000;Shouse et al, 2000;Colom et al, 2006; for review, see Matos et al, 2011;Sinha, 2011) epilepsies. Additionally, epilepsy, in turn, alters sleep patterns (Cepeda et al, 1982;Ayala-Guerro et al, 2002;Matos et al, 2010; for review, see Matos et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…There is consensus that epileptic seizures often arise from nonrapid eye movement sleep (NREM) and relaxed wake and rarely from rapid eye movement sleep (REM) or active wake states in animals (Miller et al, 1994;Shouse et al, 2000;Colom et al, 2006) and humans (Crespel et al, 2000;Herman et al, 2001;Minecan et al, 2002;Malow 2007;Ng and Pavlova, 2013). However, the relationships between SOV and seizure onset seem to be dependent on the etiology of the epilepsy model or syndrome.…”

Section: Introductionmentioning

confidence: 99%

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Rapid Eye Movement Sleep and Hippocampal Theta Oscillations Precede Seizure Onset in the Tetanus Toxin Model of Temporal Lobe Epilepsy

Sedigh-Sarvestani¹,

Thuku²,

Sunderam³

et al. 2014

J. Neurosci.

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Improved understanding of the interaction between state of vigilance (SOV) and seizure onset has therapeutic potential. Six rats received injections of tetanus toxin (TeTX) in the ventral hippocampus that resulted in chronic spontaneous seizures. The distribution of SOV before 486 seizures was analyzed for a total of 19 d of recording. Rapid eye movement sleep (REM) and exploratory wake, both of which express prominent hippocampal theta rhythm, preceded 47 and 34%, for a total of 81%, of all seizures. Nonrapid eye movement sleep (NREM) and nonexploratory wake, neither of which expresses prominent theta, preceded 6.8 and 13% of seizures. We demonstrate that identification of SOV yields significant differentiation of seizure susceptibilities, with the instantaneous seizure rate during REM nearly 10 times higher than baseline and the rate for NREM less than half of baseline. Survival analysis indicated a shorter duration of preseizure REM bouts, with a maximum transition to seizure at ϳ90 s after the onset of REM. This study provides the first analysis of a correlation between SOV and seizure onset in the TeTX model of temporal lobe epilepsy, as well as the first demonstration that hippocampal theta rhythms associated with natural behavioral states can serve a seizure-promoting role. Our findings are in contrast with previous studies suggesting that the correlations between SOV and seizures are primarily governed by circadian oscillations and the notion that hippocampal theta rhythms inhibit seizures. The documentation of significant SOV-dependent seizure susceptibilities indicates the potential utility of SOV and its time course in seizure prediction and control.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Rapid Eye Movement Sleep and Hippocampal Theta Oscillations Precede Seizure Onset in the Tetanus Toxin Model of Temporal Lobe Epilepsy

Sedigh-Sarvestani¹,

Thuku²,

Sunderam³

et al. 2014

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Generalized synchrony present in the NREM phase could enhance the propagation of post-synaptic responses (including epileptogenic discharges), concomitant with the muscular tonus that would facilitate the stereotypical movement that is observed during most seizures. Conversely, the REM phase would make such muscular events less likely to occur, as a result of the pattern of asynchronic discharges between neurons and the profound inhibition of motoneurons [41].…”

Section: Effects Of Sleep On Epilepsymentioning

confidence: 99%

The relationship between sleep and epilepsy: Evidence from clinical trials and animal models

Matos

Andersen

Valle

et al. 2010

Journal of the Neurological Sciences

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“…[17][18][19] A Academia Americana de Medicina do Sono criou o termo epilepsia relacionada ao sono (sleep-related epilepsy-SRE) para designar aquelas epilepsias, nas quais, mais de 70% das crises ocorrem durante o sono 20 tendo sido o resultado de uma série de descrições de síndromes epilépticas claramente relacionadas ao sono, iniciada pela descrição da epilepsia de lobo frontal noturna autossômica dominante. 21 Desde este relato, vários tipos de epilepsias têm sido descritos com origem cortical e etiologias variáveis, as quais se apresentam com crises, exclusiva ou predominantemente, durante o sono.…”

Section: Fisiopatologia E Definições: Sono E Epilepsiaunclassified

Avaliação da arquitetura do sono em crianças com epilepsia refratária

Pereira

Kaemmerer

Palmini

et al. 2011

J. epilepsy clin. neurophysiol.

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RESuMOIntrodução: Há um interesse crescente nas relações entre sono e epilepsia incentivado pela compreensão de que existem interações potencialmente relevantes nas duas direções. Embora o papel do sono na hipersincronização e a crescente preocupação na geração de crises sejam bem conhecidos, o grau no qual o sono pode facilitar ou induzir a um fenômeno epileptogênico, nas epilepsias lesionais, permanece indefinido. As epilepsias lesionais parecem apresentar um mecanismo particular de epileptogenicidade e o esclarecimento do papel da macro e microarquitetura do sono pode auxiliar na antecipação e monitorização de fenômenos epilépticos relacionados ao sono, conforme a etiologia da epilepsia. Objetivo: revisar e discutir as relações entre sono e epilepsia na infância e adolescência relacionando as alterações estruturais do sono à etiologia da epilepsia. Métodos: revisão bibliográfica utilizando o banco de dados Medline, abrangendo os estudos publicados nos últimos quinze anos, com as palavras-chave (unitermos) sono e epilepsia. Conclusões: epilepsia refratária durante a infância parece influenciar a organização do sono principalmente naqueles pacientes com etiologia lesional. A definição do tipo de epilepsia pode ser importante na antecipação dos distúrbios de sono nesta população.unitermos: sono, epilepsia, displasia cortical, padrão cíclico alternante. ABSTRACT Evaluation of sleep architecture in children with refractory epilepsyIntroduction: There has been a growing interest in the relations between sleep and epilepsy, kindled by the realization that there are many potentially relevant two-way interactions. Even though the hyper-synchronizing role of sleep and its attending increase in the probability of seizure generation are well known, the degree to which sleep may facilitate or induce epileptogenic phenomena in lesional epilepsies remains unclear. The lesional epilepsies seems to have intrinsic epileptogenic properties and the knowledge about sleep macro and microarchiteture could help clinician to anticipate and monitor sleep-related epileptic phenomena according to the etiology of the epilepsy Objective: Discuss the relationship between sleep and epilepsy in childhood and adolescence. Methods: Literature review in journals indexed through Medline, from the last 15 years. Conclusion: Refractory epilepsy during childhood influences sleep organization mainly in patients with lesional etiology. The definition of the type of epilepsy is important to anticipate sleep disorders in this population.

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Physiological basis: how NREM sleep components can promote and REM sleep components can suppress seizure discharge propagation

Cited by 113 publications

References 26 publications

Rapid Eye Movement Sleep and Hippocampal Theta Oscillations Precede Seizure Onset in the Tetanus Toxin Model of Temporal Lobe Epilepsy

Rapid Eye Movement Sleep and Hippocampal Theta Oscillations Precede Seizure Onset in the Tetanus Toxin Model of Temporal Lobe Epilepsy

The relationship between sleep and epilepsy: Evidence from clinical trials and animal models

Avaliação da arquitetura do sono em crianças com epilepsia refratária

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