Physiological changes due to hepatotoxicity and the protective role of some medicinal plants

Seif, Howida S. Abou

doi:10.1016/j.bjbas.2016.03.004

Cited by 70 publications

(45 citation statements)

References 77 publications

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“…Activation of enzymes like CYP2E1 in the cytochrome P-450 system causes oxidative stress which plays a key role in liver damage. The injury inflicted on liver is enhanced further due to injury to bile duct cells and hepatocytes which in turn stimulates the accumulation of bile acid in the liver (Abou Seif, 2016). In our results, there was an increase in bilirubin in BB-induced rats, which may be due to the enhanced production of bilirubin in concert with other factors as observed in aspartame induced toxicity (Choudhary and Devi, 2014).…”

Section: Discussionsupporting

confidence: 57%

A biochemical approach to the anti-inflammatory, antioxidant and antiapoptotic potential of beta-carotene as a protective agent against bromobenzene-induced hepatotoxicity in female Wistar albino rats

Akkara¹,

Sabina²

2020

JAB

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Bromobenzene is a compound which has contributed much in understanding the mechanisms involved in xenobiotic hepatotoxicity induced by drugs and environment pollutants. In the present study, the protective and ameliorative effect of beta-carotene was investigated against bromobenzene-induced hepatotoxicity and compared with silymarin, a standard hepatoprotective reference drug. Beta-carotene (10 mg/kg b.w. p.o.) was administered to the rats for 9 days before intragastric intubation of bromobenzene (10 mmol/kg b.w.). Liver marker enzymes (aspartate transaminase, alanine transaminase and alkaline phosphatase), total protein content, bilirubin, total cholesterol, high-density lipoproteins, triglycerides, antioxidant status (reduced glutathione, superoxide dismutase, catalase, glutathione-S-transferase and glutathione peroxidase) were assessed along with histopathological analysis. ELISA was performed for analysing the levels of cytokines such as TNF-α, IL-1β and IL-6 in serum and in the liver. Caspase-3, COX-2 and NF-κB were evaluated by Western blotting. Administration of bromobenzene resulted in elevated levels of liver marker enzymes, bilirubin, lipid peroxidation and cytokines but deterioration in total protein content, antioxidant levels and histopathological conditions. Pre-treatment with beta-carotene not only significantly decreased the levels of liver markers, lipid peroxidation and cytokines but also improved histoarchitecture and increased antioxidant levels minimising oxidative stress, and reduced factors contributing to apoptosis. This significant reversal of the biochemical changes on pre-treatment with beta-carotene in comparison with rats administered with bromobenzene clearly demonstrates that beta-carotene possesses promising hepatoprotective effect through its antioxidant, anti-inflammatory and antiapoptotic activity and hence is suggested as a potential therapeutic agent for protection from bromobenzene.

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Section: Discussionsupporting

confidence: 57%

A biochemical approach to the anti-inflammatory, antioxidant and antiapoptotic potential of beta-carotene as a protective agent against bromobenzene-induced hepatotoxicity in female Wistar albino rats

Akkara¹,

Sabina²

2020

JAB

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“…Therefore those enzymes utilized as biochemical markers for chemicals or druginduced liver injury in a clinical setting. Some previous study pointed a decrease in those enzymes while hepatocurative substance or antioxidants were given to CCl4-induced animals (Abou Seif, 2016;Manfo et al, 2014;Reyes-Gordillo et al, 2012).…”

Section: Resultsmentioning

confidence: 98%

Hepatoprotective effects of Curcumin-Mesoporous Silica Nanoparticles on CCl 4 -induced Hepatotoxicity Wistar rats

Hadisoewignyo

Soeliono

Hartono

et al. 2019

Indonesian J. Pharm.

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It has been reported that curcumin has a hepatoprotective effect, but its low solubility limited its utilization. Recently there was so many emerging research of advanced curcumin formulation, such as nanoparticles curcumin. In our previous study, curcumin has been loaded into mesoporous silica nanoparticles (C-MSN). This study was performed to evaluate of C-MSN hepatoprotective effect in CCl4-induced rats. Sixteen rats were divided into four groups, namely normal and CCl4 control, curcumin, C-MSN group. Treatment was given according to its group for fourteen days consecutively. At day 14, three hours after the last administration, CCl4 (1.25mL/kgBB) were administered orally. Twelve hours later the rats were sacrificed, and blood samples were drawn from their hearts. Blood serum examination result revealed that C-MSN caused a significantly lower ALT and AST than CCl4 control group (851±271U/L vs 1734±275U/L; 295±155U/L vs 1348±235U/L; p<0.05). Its effect on hepatic serum level resembled curcumin group. However, the result was not supported by histology examination which showed a higher number of necrotic hepatic cells in C-MSN group than in the curcumin group (147±9 vs 80±16; p<0.05). From this study, it can be concluded that C-MSN revealed an excellent hepatoprotective property, but it was suspected that MSN itself has the toxic effect on the liver. A further study of MSN toxicity was needed to support its safety use.

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“…There is no evident cardiotoxicity observed, showing normal cardiac muscle fibers. The liver and kidney are important organs that are responsible for the metabolism, detoxification, storage, and excretion of xenobiotics and their metabolites and are susceptible to damage by external substances (Abou Seif, 2016). The central vein (V), hepatocytes (H), and sinusoids of the liver, tubules (R) and renal corpuscles of kidney are normal.…”

Section: Resultsmentioning

confidence: 99%

Mechanical performance and biocompatibility assessment of Zn‐0.05wt%Mg‐(0.5, 1 wt%) Ag alloys

Xiao

Zhu

et al. 2020

J Biomed Mater Res

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Zn alloys are emerging as promising degradable biomedical materials due to their tailorable mechanical properties and moderate biodegradable rate, compared with conventional biodegradable metallic materials. Ag, as an effective antibacterial and reinforcing element, was incorporated into Zn‐0.05Mg alloys. In the present work, the effects of the Ag addition on mechanical, cytotoxic, hemolytic, pyrogenic, histological behaviors of the animal were investigated. The compressive yielding strength is enhanced from 198 MPa for Zn‐0.05Mg alloy up to 224 and 234 MPa for Zn‐0.05Mg‐0.5Ag and Zn‐0.05Mg‐1Ag alloys, respectively. When the compressive strain was 65%, the strength of the Zn‐0.05Mg‐1.0Ag alloy reached 833 MPa, which was much higher than that of 721 MPa for Zn‐0.05Mg alloy. The relative growth rate (RGR) for the extracts of Zn‐0.05Mg‐1Ag alloy with the concentrations of 10, 50, and 100% after 5 days incubation reaches 98.5, 95.2, and 94.2%, which are higher than those in extracts of Zn‐0.05Mg‐0.5Ag alloy (98.2, 93.9, 92.1%). The hemolysis rate of the Zn‐0.05Mg alloys with 0.5 and 1 wt% Ag is 2.46 and 2.28%, respectively. The variations of body weight and temperature, postinjection symptoms, pathological morphologies of the visceral organs demonstrate that the alloys are nontoxic according to the toxicity rating standards. Zn‐0.05wt%Mg‐(0.5, 1 wt%) Ag alloys are experimentally safe materials and promising for the future application as biodegradable medical devices.

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Physiological changes due to hepatotoxicity and the protective role of some medicinal plants

Cited by 70 publications

References 77 publications

A biochemical approach to the anti-inflammatory, antioxidant and antiapoptotic potential of beta-carotene as a protective agent against bromobenzene-induced hepatotoxicity in female Wistar albino rats

A biochemical approach to the anti-inflammatory, antioxidant and antiapoptotic potential of beta-carotene as a protective agent against bromobenzene-induced hepatotoxicity in female Wistar albino rats

Hepatoprotective effects of Curcumin-Mesoporous Silica Nanoparticles on CCl 4 -induced Hepatotoxicity Wistar rats

Mechanical performance and biocompatibility assessment of Zn‐0.05wt%Mg‐(0.5, 1 wt%) Ag alloys

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