Physiological changes in pregnancy

Bisphenol A (BPA) pharmacokinetics with daily oral bolus or continuous exposure via silastic capsules in pregnant rhesus monkeys: Relevance for human exposures

“…In women, these include expansion of body fluids, an increase of cardiac output (+30–50%), alteration of regional blood flow, an increase of glomerular filtration rate (GFR), and changes of the activity of hepatic drug metabolizing enzymes that can affect the clearance of chemicals. These effects are most pronounced in the last part of pregnancy during the period of rapid fetal growth [43, 44]. …”