Physiological changes in the bloodstream of chick embryos exposed to teratogenic doses of hypoxia

Grabowski, Casimer T.

doi:10.1016/0012-1606(66)90064-9

Cited by 64 publications

(22 citation statements)

References 14 publications

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“…The influence of hypoxia has been examined previously in chick embryos older than those used in the present study. Nevertheless, the described abnormalities are similar to those of embryos developed in DME under an air mixture in our experiments, e.g., slow development, impaired growth, and abnormal heart formation (Grabowski and Schroeder, 1968;Altimiras and Phu, 2000). It also has been shown that cervical flexure depends on oxygen supply to the embryo (Manner et al, 1995).…”

Section: Discussionsupporting

confidence: 85%

Cardiac looping in experimental conditions: Effects of extraembryonic forces

Voronov

Taber

2002

Developmental Dynamics

105

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The chick embryo is a popular experimental model used to study the mechanisms of cardiac looping. To facilitate oxygen transport, researchers typically culture the embryo on the surface of the medium. Such preparations, however, expose the embryo and the heart to surface tension that is not present in ovo. This study investigates the influence that surface and extraembryonic membrane tensions have on looping morphology. To eliminate surface tension, we developed a technique in which the embryo is cultured under a thin layer of fluid. To eliminate membrane tension, the membrane was removed. Our results show that both tensions can affect looping, with surface tension potentially having a much greater effect. Moreover, we show that surface tension can alter results in one classic looping experiment.

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Section: Discussionsupporting

confidence: 85%

Cardiac looping in experimental conditions: Effects of extraembryonic forces

Voronov

Taber

2002

Developmental Dynamics

105

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“…This pattern was observed also by Grabowski [1964Grabowski [ , 1966 and Grabowski and Chernoff[ 1970] in chick and rat embryos treated with different teratogenic agents; it could be related to an increase in extracellular and circulating fluids (edema and hypervolemia) that could result in alterations of blood pressure and flow patterns. It is well known that these hemodynamic factors are very important in molding the embryonic cardiovascular sys tem [Jaffee, 1965[Jaffee, , 1977.…”

Section: Discussionmentioning

confidence: 52%

Morphogenesis of Aortic Arch Malformations in Rat Embryos after Maternal Treatment with Glycerol Formal during Pregnancy

Giavini¹,

Vismara²

1981

Cells Tissues Organs

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The morphogenesis of the aortic arch system was studied in rat embryos whose mothers had been treated with glycerol formal (GF) during pregnancy. The fetuses were removed from the uterus on days 13–17 of gestation and India ink was injected into their vascular system while they were still alive. The teratogenic effect of GF manifests itself by developmental retardation of the aortic arch system, vessel dilatation and persistence or anomalous regression of embryonic vessels. These conditions result in several aortic arch malformations: right aortic arch, double aortic arch and persistence of the 3rd aortic arch.

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“…where chick embryos exposed to teratogenic doses of hypoxia were analysed (Grabowski and Schroeder, 1968). Following this studies relating to preimplantation embryonic development were published (Colly-d'Hooghe, Valleron, Malaise, 1977;Milligan, Harris, Dennis, 1978;Lueck and Aladjem, 1980;Massip and Mulnard, 1980;Milligan, Harris, Dennis, 1980;Schatten and Schatten, 1980;Alexandre and Mulnard, 1988).…”

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confidence: 99%