Physiological Factors Affecting Salivary Flow Rate, Oral Sugar Clearance, and the Sensation of Dry Mouth in Man

Dawes, C.

doi:10.1177/00220345870660s107

Cited by 376 publications

(285 citation statements)

References 43 publications

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“…The volume of saliva was reduced by approximately 75%. In human beings, the symptoms of xerostomia can be observed when the salivary flow is reduced by 40 to 50% 5,8 . After surgery, the oral cavity of the mice was dry, presenting only residual viscous saliva and food on mucous tissue and teeth.…”

Section: Discussionmentioning

confidence: 99%

Oral candidosis by Candida albicans in normal and xerostomic mice

et al. 2004

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The aim of this study was to analyze the effect of sialoadenectomy on the development of oral candidosis after one or four inoculations of Candida albicans. Initially, a suspension containing 10(8) cells/ml of C. albicans ATCC 36801 was prepared. Seventy-eight sialoadenectomized mice and a similar amount of mice with normal salivary flow received a single inoculation of C. albicans suspension. Another group with a similar number of mice received 4 inoculations. The control group consisted of 6 sialoadenectomized mice and 6 mice with normal salivary flow that were not inoculated with C. albicans. Candidosis development was studied histologically in the tongue of the animals 1, 2, 3, 5, and 8 days after inoculation and at 15-day intervals up to 165 days. According to the results obtained, it could be concluded that sialoadenectomy and a higher frequency of yeast inoculation influenced the presence and extension of candidosis lesions.

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Section: Discussionmentioning

confidence: 99%

Oral candidosis by Candida albicans in normal and xerostomic mice

et al. 2004

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“…These plastic cylinders (containing saliva) were then weighed and the flow rate was calculated in g/ml which is almost equivalent to ml/min [7].…”

Section: Estimation Of Flow Rate Of Salivamentioning

confidence: 99%

Evaluation of Flow Rate, pH, Buffering Capacity, Calcium, Total Proteins and Total Antioxidant Capacity Levels of Saliva in Caries Free and Caries Active Children: An In Vivo Study

Preethi¹,

Dodawad

Anand³

2010

Ind J Clin Biochem

110

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The purpose of this study was to evaluate the relationship between the physicochemical properties of saliva such as flow rate, pH, buffering capacity, calcium level, total protein and total antioxidant levels in caries free and caries active children. The present study included one hundred and twenty healthy children who were divided into two groups; group I and group II comprising of age groups 7-10 and 11-14 years, respectively. Both the groups were then sub-divided equally according to gender. They were further divided into caries free and caries active with 15 children in each group. Unstimulated saliva was collected by suction method and flow rates were determined. The samples were then analyzed for pH, buffering capacity, total protein, calcium and total antioxidant capacity. The data was statistically analyzed using student t test (unpaired). The results revealed that when all these parameters were compared among the caries free and caries active children, flow rate, pH, buffering capacity were slightly reduced in caries active children, but total protein and total antioxidant capacity of saliva increased significantly in caries active children and the total calcium decreased significantly in caries active children. Within the limitation of this study, we conclude that, the physicochemical properties of saliva play a major role in the development of caries.

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“…As causas podem ser decorrentes de alguma infecção presente, alterações provenientes do uso de um determinado medicamento, do tipo de tratamento realizado, entre outros. A coleta da saliva contribui, portanto, para monitorar o estado da saúde e da doença de um indivíduo de forma a detectar problemas de forma rápida e eficácia (DAWES, 1987;SLAVKIN, 1999).…”

Section: Discussionunclassified

Saúde Bucal E Qualidade De Vida No Paciente Pós-Radioterapia De Câncer De Cabeça E Pescoço

Oliveira

Teixeira

Rubira

et al. 2017

Iniciac cient Cesumar

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RESUMO:A radioterapia no paciente com câncer de cabeça e pescoço pode resultar em muitas consequências negativas, como a hipossalivação. Sem a proteção da saliva há um risco aumentado de cáries e doenças periodontais que podem causar a perda dentária e consequentemente influenciam no impacto da saúde bucal na qualidade de vida. O objetivo desse estudo foi avaliar o impacto da saúde bucal na qualidade de vida dos pacientes pós-radioterapia de câncer de cabeça e pescoço por meio das avaliações de fluxo salivar e edentulismo. A amostra foi composta por 19 indivíduos com idade a partir de 18 anos e diagnóstico de câncer de cabeça e pescoço. A radioterapia do tipo Intensidade Modulada (IMRT) foi o tratamento mais realizado 16 (68,4%). Referente ao tempo pós-radioterapia, nove (47,4%) haviam terminado o tratamento há um ano. Quanto ao impacto da saúde bucal na qualidade de vida, 15 (79,9%) apresentaram algum impacto. O maior número de pacientes, sete (36,8 %), não usava algum tipo de prótese e nove (47,4%) necessitavam de uma combinação de reabilitações. Encontraram-se 15 (78,9%) pacientes com fluxo salivar classificado como muito baixo e quatro (21,1 %) mostraram melhor fluxo salivar após cinco anos da radioterapia. O teste de Coeficiente de Correlação de Pearson mostrou correlação entre a necessidade de prótese e a idade (p=0,006; r=0,4734) e a necessidade de prótese e o fluxo salivar dos pacientes (p=0,03; r=0,3672). As complicações da radioterapia em cabeça e pescoço acarretam uma série de consequências físicas e psicológicas. O tempo após a radioterapia parece influenciar, em alguns casos, a melhora do fluxo salivar e em menos de um ano de tratamento não há impacto da saúde bucal na qualidade de vida. São necessários estudos longitudinais com essa população para a verificação dos efeitos da radioterapia ao longo dos anos. PALAVRAS-CHAVE:Neoplasias de cabeça e pescoço; Radioterapia; Saúde bucal; Qualidade de vida. MOUTH HEALTH AND LIFE QUALITY IN THE PATIENT HEAD AND NECK CANCER AFTER RADIOTHERAPYABSTRACT: Radiotherapy in a patient with head and neck cancer may produce several negative consequences, such as hypo-salivation. Due to lack of protection by saliva, increase in the number of caries and other periodontal diseases is a risky problem which may cause teeth loss and may impact life quality through mouth health. The impact of mouth health on life quality of post-radiotherapy patients with head and neck cancer is evaluated by evaluating saliva flow and toothlessness. Sample comprised 19 individuals, over 18 years, diagnosed with head and neck cancer. Modulated Intensity Radiotherapy featured in 16 (68.4%) patients, of whom nine (47.4%) ended treatment one year before. Fifteen patients (79.9%) experienced mouth health impacting their life quality. Seven patients (36.8%) did not wear any prosthesis and nine (47.4%) required a combination of rehabilitations. Fifteen (78.9%) patients had low saliva flow and four (21.1%) had better saliva flow after five years of radiotherapy. Pearson´s Coefficient of Co-relation r...

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Physiological Factors Affecting Salivary Flow Rate, Oral Sugar Clearance, and the Sensation of Dry Mouth in Man

Cited by 376 publications

References 43 publications

Oral candidosis by Candida albicans in normal and xerostomic mice

Oral candidosis by Candida albicans in normal and xerostomic mice

Evaluation of Flow Rate, pH, Buffering Capacity, Calcium, Total Proteins and Total Antioxidant Capacity Levels of Saliva in Caries Free and Caries Active Children: An In Vivo Study

Saúde Bucal E Qualidade De Vida No Paciente Pós-Radioterapia De Câncer De Cabeça E Pescoço

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