2013
DOI: 10.4236/anp.2013.24046
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Physiological Fluid Specific Agglomeration Patterns Diminish Gold Nanorod Photothermal Characteristics

Abstract: Investigations into the use of gold nanorods (Au-NRs) for biological applications are growing exponentially due to their distinctive physicochemical properties, which make them advantageous over other nanomaterials. Au-NRs are particularly renowned for their plasmonic characteristics, which generate a robust photothermal response when stimulated with light at a wavelength matching their surface plasmon resonance. Numerous reports have explored this nanophotonic phenomenon for temperature driven therapies; howe… Show more

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Cited by 12 publications
(14 citation statements)
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“…This is due to the fact that NP properties are strongly dependent on their surrounding environment [30,31]. DLS analysis indicated that the particles did agglomerated in SF media, with an approximate hydrodynamic diameter of 150 nm.…”
Section: Characterization and Dosage Selection Of Agnpsmentioning
confidence: 97%
See 1 more Smart Citation
“…This is due to the fact that NP properties are strongly dependent on their surrounding environment [30,31]. DLS analysis indicated that the particles did agglomerated in SF media, with an approximate hydrodynamic diameter of 150 nm.…”
Section: Characterization and Dosage Selection Of Agnpsmentioning
confidence: 97%
“…During this process, endosomes progress into lysosomes, introducing the internalized AgNPs to a low pH environment. Environmental factors have been shown to dramatically alter NP behavior, including increased rates of ionic dissolution [31,30,38], thereby intensifying ion-dependent effects. The question then arises of whether this continual ion release could potentially result in modifications to cell functionality and basal stress levels over time.…”
Section: Sustained Effects By Internalized Agnpsmentioning
confidence: 99%
“…For example, the inclusion of physiological fluids, either artificially synthesized or procured from an in vivo source, replicates an environment that NPs will likely encounter. Current studies using physiological fluids have demonstrated that environmental factors modulate both NP-NP and NPcell interactions [17][18][19]. Moreover, the cardiovascular system surrounds all tissues, producing either direct or indirect fluid movement.…”
Section: Introductionmentioning
confidence: 99%
“…Modification to the protein corona and NP properties were observed following incubation in interstitial and lysosomal fluids (Figures 3-5). Interstitial fluid is the most prevalent fluid in an in vivo system and is known to impact NP characteristics [22,23], but its influence on the protein corona had been previously unexplored. As artificial interstitial fluid had no protein component, a significant concentration gradient existed between the corona and the environment: providing a driving force for protein dissociation.…”
Section: Discussionmentioning
confidence: 99%
“…Following the formation of a corona, the influences of both shear stress and fluid environment on the corona-NP complex were evaluated. Artificial biological fluids have previously been utilized to explore NP behavior and were chosen for this study due to their ability to mimic an in vivo environment while allowing for accurate and reproducible characterization of NP response and the surrounding corona [22][23][24]. We identified that exposure to these target physiological variables disrupted the corona structure and altered target NP parameters.…”
mentioning
confidence: 99%