Physiological inducers of the acrosome reaction

Hoshi, Motonori; Matsui, Taei; Nishiyama, Isa; Amano, Toshikazu; Okita, Yoshihito

doi:10.1016/0922-3371(88)90095-0

Cited by 17 publications

(15 citation statements)

References 14 publications

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“…A variety of ligands have been reported to modulate AR exerting their effects by means of receptors at the level of the spermatozoon plasma membrane (Ohzu and Yanagimachi, 1982;Meizel, 1985;Hoshi et al, 1988;Morales et al, 1992;Llanos et al, 1993;Llanos et al, 1995;DelRío et al, 2007;Vigil et al, 2008). Some of these compounds are distributed in specifi c sectors of the female reproductive tract, probably exerting an in situ AR control (DelRío et al, 2007).…”

Section: Modulators Of Armentioning

confidence: 99%

Modulation of spermatozoon acrosome reaction

Vigil¹,

Orellana²,

Cortés³

2011

Biol. Res.

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Spermatozoon acrosome reaction is an exocytotic event of the utmost importance for the development of mammalian fertilisation. Current evidence shows that the triggering of the acrosome reaction (AR) could be regulated by the action of diverse compounds, namely, metabolites, neurotransmitters and hormones. The aim of the present review is to describe the modulating effects of several compounds that have been classifi ed as inductors or inhibitors of acrosome reaction. Among AR inductors, it is necessary to mention progesterone, angiotensin II, atrial natriuretic peptide, cathecolamines, insulin, leptin, relaxin and other hormones. Regarding the inhibitors, oestradiol and epidermal growth factor are among the substances that retard AR. It is worth mentioning that gamma-aminobutyric acid, a neurotransmitter known to be an inhibitor in the central nervous system, has been shown to induce AR. The multiple hormones located in the fl uids of the female reproductive tract are also likely to act as subtle regulators of AR, constituting a fundamental aspect for the development of successful fertilisation. Finally, it is necessary to emphasise that the study of regulation exerted by hormones and other compounds on AR is essential for further understanding of mammalian reproductive biology, especially spermatozoon physiology.

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Section: Modulators Of Armentioning

confidence: 99%

Modulation of spermatozoon acrosome reaction

Vigil¹,

Orellana²,

Cortés³

2011

Biol. Res.

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“…These factors act at the correct time and place in or around egg-jelly, thereby leading to successful fertilization. Carbohydrate components are responsible for the activity of these molecules in some cases (SeGall and Lennarz, 1979;Keller and Vacquier, 1994a;Hoshi et al, 1988;Hoshi et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

“…It contains a large amount of carbohydrates (Bonnell et al, 1993) and several factors for inducing chemotaxis (sea urchin: Ward et al, 1985;Xenopus laevis: Al-Anzi and Chandler, 1998), initiation/activation of motility (Discoglossus pictus: Campanella and Gabbiani, 1979;sea urchin: Suzuki and Garbers, 1984;Suzuki, 1990; Cynops pyrrhogaster : Ukita et al, 1999) and acrosome reaction (starfish: Hoshi et al, 1988;sea urchin: Keller and Vacquier, 1994a; Cynops pyrrhogaster: Onitake et al, 2000) in sperm. Egg-jelly also sustains cations that support the induction of the sperm-egg interaction (Bufo japonicus: Ishihara et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

Organization of Carbohydrate Components in the Egg-Jelly Layers of the Newt, Cynops pyrrhogaster

2001

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“…In sea urchins, the AR occurs when spermatozoa reach the extracellular matrix of the egg (jelly coat) and fucose sulfate polymer in the jelly is the AR inducer (Kopf and Garbers, 1980). In starfish, the mixture of the glycoprotein (acrosome reaction-inducing substance: ARIS) and the steroid saponin (Co-ARIS), or a peptide comprised of 34 amino acids (asterosap) are potent in inducing the AR (Hoshi et al, 1988;Nishigaki et al, 1996). Similarly, the 300 kDa glycoprotein secreted from the oviductal pars recta, referred to as ARISX, is an authentic AR inducer in Xenopus laevis (Ueda et al, 2003), whereas progesterone is reported to have a AR inducing action in mouse and human sperm (Roldan et al, 1994;Osman et al, 1989).…”

Section: Sperm Acrosome Reactionmentioning

confidence: 99%

Sperm-Egg Interaction during Fertilization in Birds

et al. 2016

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Fertilization in animals that employ sexual reproduction is an indispensable event for the production of the next generation. A significant advancement in our understanding of the molecular mechanisms of sperm-egg interaction in mammalian species was achieved in the last few decades. However, the same level of knowledge has not been accumulated for birds because of egg size and the difficulty in mimicking the physiological polyspermy that takes place during normal fertilization. In this review, we summarize the current understanding of sperm-egg interaction mechanism during fertilization in birds, especially focusing on sperm-egg binding, sperm acrosome reaction and the authentic sperm protease required for the hole formation on the perivitelline membrane. We explain that the zona pellucida proteins (ZP1 and ZP3) in the perivitelline membrane play important roles in sperm-egg binding, induction of the acrosome reaction as well as sperm penetration by digestion of sperm protease. We anticipate that a deeper understanding of avian fertilization will open up new avenues to create powerful tools for a myriad of applications in the poultry industries including the production of transgenic and cloned birds.

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Physiological inducers of the acrosome reaction

Cited by 17 publications

References 14 publications

Modulation of spermatozoon acrosome reaction

Modulation of spermatozoon acrosome reaction

Organization of Carbohydrate Components in the Egg-Jelly Layers of the Newt, Cynops pyrrhogaster

Sperm-Egg Interaction during Fertilization in Birds

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