Physiological Mechanisms of Airway Hyperresponsiveness in Obese Asthma

Bates, Jason H. T.

doi:10.1165/rcmb.2016-0019ps

Cited by 46 publications

(37 citation statements)

References 57 publications

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“…The same mechanism is suggested for the decrease in IC [9]. In our study, a more pronounced bronchial obstruction was in obese asthmatics with FEV 1 67.8 ± 2.1 % compared to those without obesity 74.9 ± 2.4 %, P < 0.05 that can be explained by a higher degree of bronchial hyperreactivity in BA-obesity phenotype [10]. The literature indicates that even obese non-asthma tics may have a significant airway obstruction due to small airway collapse when lung volume is reduced [11].…”

Section: Discussionsupporting

confidence: 83%

Lung ventilation impairment in asthma patients with obesity

Feshchenko¹,

Гуменюк²,

Gumeniuk³

et al. 2019

ZMJ

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Section: Discussionsupporting

confidence: 83%

Lung ventilation impairment in asthma patients with obesity

Feshchenko¹,

Гуменюк²,

Gumeniuk³

et al. 2019

ZMJ

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“…High BMI can affect the frequency dependence likely indicative of obesity causing peripheral airway closure and hence, heterogeneity. 75,[94][95][96] The CV 5 is 11%, less than 15%, and hence the study is of acceptable quality. The R 5 is significantly above the reference value for a normal subject's R 5 with a Z-score over 3.…”

Section: Copd With Emphysemamentioning

confidence: 96%

Applications of oscillometry in clinical research and practice

Lundblad

Siddiqui

Bossé

et al. 2019

Canadian Journal of Respiratory, Critical Care, and Sleep Medic

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Oscillometry is gaining in clinical use and while there is an increased interest in the technique, there is paucity in the understanding of its possibilities and limitations. Oscillometry has seen extensive use in research over several decades, but only recently is the technique being adopted in clinical practice; hence, there is a need to educate the novel users. The goal of the mini symposium arranged in San Diego in 2018 was to discuss the principles of oscillometry, showcase some of the recent ongoing research using this technique and to demonstrate how oscillometry may be used in clinical practice. It was concluded that oscillometry has several advantages over spirometry, most notably, with novel data being shown, its sensitivity allowing early detection of small airways disease not possible with spirometry and it can be used in subjects who have difficulties performing forced maneuvers such as preschool children, the elderly and subjects with handicaps. The site of respiratory pathology can be reflected by the various parameters generated by oscillometry and thus help with both disease diagnosis and localization. While the interpretation of oscillometry parameters and translating them into meaningful pathological correlates is still evolving, it is likely that oscillometry will soon be at the forefront of both pulmonary clinical practice and research. R ESUM EL'oscillom etrie est de plus en plus utilis ee en contexte clinique, mais malgr e l'int erêt accru pour cette technique, la compr ehension de ses possibilit es et de ses limites est encore insuffisante. Pendant plusieurs d ecennies, l'oscillom etrie a largement et e utilis ee dans la recherche, mais l'adoption de cette technique dans la pratique clinique est encore r ecente, de sorte qu'il est n ecessaire de former les nouveaux utilisateurs. Le but de ce mini symposium qui s'est tenu a San Diego en 2018 etait de discuter des principes de l'oscillom etrie, de pr esenter les plus r ecentes etudes utilisant cette technique et de d emontrer comment elle peutêtre utilis ee dans la pratique clinique. Il a et e d etermin e que l'oscillom etrie pr esentait plusieurs avantages par rapport a la spirom etrie notamment, comme le d emontrent de nouvelles donn ees, sa sensibilit e qui permet la d etection pr ecoce de la maladie des petites voies a eriennes, ce que la spirom etrie ne peut pas faire, ainsi que le fait qu'elle puisseêtre utilis ee aupr es de sujets qui eprouvent de la difficult e a effectuer des manoeuvres forc ees comme les enfants d'âge pr escolaire, les personnesâg ees et les personnes atteintes d'un handicap. L'emplacement de la pathologie respiratoire peut se refl eter dans les divers param etres produits par la spirom etrie, ce qui peut contribuer a diagnostiquer la maladie et a la localiser. Bien que l'interpr etation des param etres de l'oscillom etrie et leur traduction dans des corr elats pathologiques significatifs continue d' evoluer, l'oscillom etrie sera vraisemblablement a l'avant-plan de la pratique clinique et de la recherche pulmonair...

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“…As detailed elsewhere in this issue (54,55), obesity has been associated with a greater prevalence and severity of asthma in human populations, and recent studies have strongly suggested that these associations reflect a causal connection, because weight gain has been shown to increase the risk of incident asthma and its severity (56,57), whereas weight loss may ameliorate this effect (58,59). Recent clinical studies have yielded tantalizing insights as to the possibility that "obese asthma" may reflect at least two distinct allergic and nonallergic phenotypes (60) and have suggested a differential role for discrete elements of the metabolic syndrome in altering both the innate and the adaptive arms of the immune response in asthma (61).…”

Section: Asthmamentioning

confidence: 98%

Mouse Modeling of Obese Lung Disease. Insights and Caveats

Suratt

2016

Am J Respir Cell Mol Biol

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As the obesity epidemic has worsened, its impact on lung health and disease has become progressively evident. The interactions between obesity and the accompanying metabolic syndrome and diseases such as asthma, pneumonia, and acute respiratory distress syndrome (ARDS) have proven complex and often counterintuitive in human studies. Hence, there is a growing need for relevant experimental approaches to understand the interactions between obesity and the lung. To this end, researchers have increasingly exploited mouse models combining both obesity and lung diseases, including ARDS, pneumonia, and asthma. Such models have both complemented and advanced the understanding we have gained from clinical studies and have allowed elegant dissections of obesity's effects on the pathogenesis of lung disease. Yet these models come with several critically important caveats that we must reflect on when interpreting their results.

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Physiological Mechanisms of Airway Hyperresponsiveness in Obese Asthma

Cited by 46 publications

References 57 publications

Lung ventilation impairment in asthma patients with obesity

Lung ventilation impairment in asthma patients with obesity

Applications of oscillometry in clinical research and practice

Mouse Modeling of Obese Lung Disease. Insights and Caveats

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