Physiological Role of a Slow, Voltage‐sensitive, Synaptic Response Mediated by an Identified Serotonin‐containing Neurone

Cottrell, G. A.

doi:10.1113/expphysiol.1982.sp002612

Cited by 15 publications

(8 citation statements)

References 8 publications

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“…Our results suggest that the mechanism of this facilitation is more general in that NA makes the cell more responsive to any excitatory stimulus by blocking the cell's intrinsic inhibitory GK(ca). This action is similar in many ways to excitatory effects reported in other systems such as serotonergic excitation of myenteric neurones (Grafe et al 1980) or activation of a presynaptic serotonergic neurone on a follower neurone in Helix (Cottrell, 1982).…”

Section: Discussionmentioning

confidence: 63%

“…is that NA is not the only neurotransmitter that has this action. Acetylcholine (Benardo & Prince, 1982;North & Tokimasa, 1983;Cole & Nicoll, 1984), serotonin (Grafe et al 1980, Cottrell, 1982, histamine (Haas & Konnerth, 1983) and corticotropin releasing factor (Aldenhoff, Gruol, Rivier, Vale & Siggins, 1983) all decrease calcium-activated potassium a.h.p.s in various neuronal preparations. That such a diverse array of putative neurotransmitters can block this potassium conductance, and that this blockade has such a profound effect on the responsiveness of the affected neurone, implies strongly that the calcium-activated potassium channel plays a central role in the regulation of neuronal excitability, and indeed that it may serve as a final common path for the actions of many neurotransmitters.…”

Section: Discussionmentioning

confidence: 99%

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Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones, in vitro.

Madison¹,

Nicoll²

1986

The Journal of Physiology

372

189

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SUMMARY1. CA1 pyramidal neurones were studied in rat in vitro hippocampal slices using standard intracellular and single-electrode voltage-clamp recording techniques to examine the actions of noradrenaline (NA).2. NA had two different effects on the resting membrane potential of pyramidal neurones; either a hyperpolarization accompanied by a decrease in membrane input resistance, or less commonly, a depolarization accompanied by an increase in input resistance. In many cells, both effects, a hyperpolarization followed by a depolarization were observed. The depolarization was mediated by a noradrenergic f-receptor.The hyperpolarization was more difficult to characterize, but may result from a-receptor activation.3. NA reduced the amplitude and duration ofthe slow calcium-activated potassium after-hyperpolarization (a.h.p.) that follows depolarization-induced action potentials. This action of NA was mediated by ,l1-noradrenergic receptors.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones, in vitro.

Madison¹,

Nicoll²

1986

The Journal of Physiology

372

189

View full text Add to dashboard Cite

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“…Accompanying the voltage-dependent response in Helix is a broadening of the action potential (Cottrell, 1982;Paupardin-Tritsch, DeTerre, and Gerschenfeld, 1981) similar to that reported by Klein and Kandel (1978) in sensory neurons of Aplysia. Klein and Kandel (1980) have suggested that the mechanism underlying this serotonin-elicited spike broadening is a decrease in potassium conductance.…”

Section: Introductionmentioning

confidence: 82%

Enhancement of inward current by serotonin in neurons of Aplysia

Pellmar

1984

J. Neurobiol.

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In RB cells of Aplysia, serotonin, in the presence of TEA, 4AP and Ba, elicits a voltage-dependent inward current. In Ba-TEA-4AP seawater, RB cells showed a negative slope region (NSR) in their current-voltage (I-V) relationship when measured at the end of 2-s commands from a holding potential of -60 mV. Addition of serotonin to the bathing solution enhanced the NSR. When holding potential was lowered to -10 mV, the NSR as well as the effects of serotonin were greatly reduced. Addition of 20 mM cobalt to the bathing solution blocked both the NSR and the inward current produced by serotonin. Changes in potassium concentration produced no consistent shift in voltage sensitivity nor change in amplitude of the current elicited by serotonin. Intracellular injection of cesium sufficient to broaden action potentials did not block the enhancement of NSR by serotonin. These results support the conclusion that in RB cells, serotonin produces a voltage-dependent current carried by calcium ions.

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“…The response began to occur at about the same potential at which the delayed rectification was activated. The ionic mechanism of this response was studied by Cottrell (1982 a), and therefore only a summary of those results previously described will be given here, along with results from some additional experiments.…”

Section: Resultsmentioning

confidence: 99%

“…The present report describes the effects of FMRFamide, and of two homologous peptides, Phe-Nle-Arg-Phe-NH2 (FnLRFamide) and Tyr-Gly-Gly-Phe-Met-Arg-Phe-NH2 (YGGFMRFamide), on a number of different specified neurones in the ganglia of Helix aspersa. Some of this work has been published in abstract (Cottrell, 1982 a). METHODS Experiments were made on identified neurones in the cerebral, visceral and right parietal ganglia of Helix asper8a.…”

Section: Introductionmentioning

confidence: 99%

Multiple actions of a molluscan cardioexcitatory neuropeptide and related peptides on identified Helix neurones.

Cottrell¹,

Davies²,

Green³

1984

The Journal of Physiology

115

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SUMMARY1. The effects of the molluscan neuropeptide Phe-Met-Arg-Phe-NH2 (FMRF amide) and related peptides (Price & Greenberg, 1977) were tested on Helix aspersa neurones.2. Ionophoretic application ofFMRFamide depolarized and excited some neurones, but hyperpolarized and inhibited others. In some neurones the sign of the response was dependent on the membrane potential.3. Two responses resulted from an increase in membrane conductance, a depolarizing response mediated mainly by an increase in Na+ ion permeability, and a hyperpolarizing response mediated by an increase in K+ ion permeability.4. In the C1 neurone a voltage-dependent response was observed, which only occurred when the neurone was depolarized from its resting level. This response was recorded as an inward current during voltage clamp and resulted from a decrease in K current(s), possibly Ca-activated K current.5. More than one response may occur in a single neurone. In the CI neurone, the K-mediated hyperpolarization occurred as well as the voltage-dependent response, while the depolarization seen in the F2 neurone was a combination of an increase in Na conductance and an increase in K conductance.

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Physiological Role of a Slow, Voltage‐sensitive, Synaptic Response Mediated by an Identified Serotonin‐containing Neurone

Abstract: SUMMARYIn Helix, activation of an identified serotonin-containing neurone produces a slow, markedly voltage-sensitive, depolarizing synaptic potential in another identified neurone, the A neurone.

Cited by 15 publications

References 8 publications

Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones, in vitro.

Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones, in vitro.

Enhancement of inward current by serotonin in neurons of Aplysia

Multiple actions of a molluscan cardioexcitatory neuropeptide and related peptides on identified Helix neurones.

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