Physiological Significance of Helical Flow in the Arterial System and its Potential Clinical Applications

Liu, Xiao; Sun, Anqiang; Fan, Yubo; Deng, Xiaoyan

doi:10.1007/s10439-014-1097-2

Cited by 135 publications

(104 citation statements)

References 107 publications

(168 reference statements)

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“…Previously, Liu et al 22. discussed that existing helical flow may also play positive physiological roles in enhancing blood flow transport, suppressing disturbed blood flow, preventing the accumulation of atherogenic low density lipoproteins on the luminal surfaces of arteries, enhancing oxygen transport from the blood to the arterial wall and reducing the adhesion of blood cells on the arterial surface22.…”

Section: Discussionmentioning

confidence: 99%

The influence of the aortic valve angle on the hemodynamic features of the thoracic aorta

Kim

Kweon

et al. 2016

Sci Rep

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Since the first observation of a helical flow pattern in aortic blood flow, the existence of helical blood flow has been found to be associated with various pathological conditions such as bicuspid aortic valve, aortic stenosis, and aortic dilatation. However, an understanding of the development of helical blood flow and its clinical implications are still lacking. In our present study, we hypothesized that the direction and angle of aortic inflow can influence helical flow patterns and related hemodynamic features in the thoracic aorta. Therefore, we investigated the hemodynamic features in the thoracic aorta and various aortic inflow angles using patient-specific vascular phantoms that were generated using a 3D printer and time-resolved, 3D, phase-contrast magnetic resonance imaging (PC-MRI). The results show that the rotational direction and strength of helical blood flow in the thoracic aorta largely vary according to the inflow direction of the aorta, and a higher helical velocity results in higher wall shear stress distributions. In addition, right-handed rotational flow conditions with higher rotational velocities imply a larger total kinetic energy than left-handed rotational flow conditions with lower rotational velocities.

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Section: Discussionmentioning

confidence: 99%

The influence of the aortic valve angle on the hemodynamic features of the thoracic aorta

Kim

Kweon

et al. 2016

Sci Rep

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“…Interested readers are referred to a recent review by Liu et al [20] for an extensive overview of the potential clinical applications of helical flows.…”

Section: Introductionmentioning

confidence: 99%

“…While the physiological importance of secondary motion in circulation has clearly been highlighted in the literature [6,7], the benefits of helical/spiral prostheses in vascular conduits have yet to be firmly established [20–22]. The overall aim of the present work is to investigate the hemodynamic effects of inducing secondary flow in a typical end-to-side distal graft anastomosis and to assess its effectiveness in improving the distribution of hemodynamic factors.…”

Section: Introductionmentioning

confidence: 99%

Numerical Assessment of Novel Helical/Spiral Grafts with Improved Hemodynamics for Distal Graft Anastomoses

et al. 2016

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In the present work, numerical simulations were conducted for a typical end-to-side distal graft anastomosis to assess the effects of inducing secondary flow, which is believed to remove unfavourable flow environment. Simulations were carried out for four models, generated based on two main features of 'out-of-plane helicity' and 'spiral ridge' in the grafts as well as their combination. Following a qualitative comparison against in vitro data, various mean flow and hemodynamic parameters were compared and the results showed that helicity is significantly more effective in inducing swirling flow in comparison to a spiral ridge, while their combination could be even more effective. In addition, the induced swirling flow was generally found to be increasing the wall shear stress and reducing the flow stagnation and particle residence time within the anastomotic region and the host artery, which may be beneficial to the graft longevity and patency rates. Finally, a parametric study on the spiral ridge geometrical features was conducted, which showed that the ridge height and the number of spiral ridges have significant effects on inducing swirling flow, and revealed the potential of improving the efficiency of such designs.

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“…Here, it was found that aortic distortion is more pronounced in the PG, therefore the underlying flow patterns are expected to be more intricate and complex for the PG [41] than for the CG. The distortion observed in PG, and the consequent reshaping imposed to flow structures, does represent a point of attention, because curvature and torsion have a well-known influence on arterial hemodynamics, in particular on the arrangement of flow in helical structures, that has been reported to limit flow disturbances [42][43][44] .…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular morphometry with high-resolution 3D magnetic resonance: First application to left ventricle diastolic dysfunction

Gallo

Vardoulis

Monney

et al. 2017

Medical Engineering & Physics

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a b s t r a c tIn this study, an image-based morphometry toolset quantifying geometric descriptors of the left ventricle, aorta and their coupling is applied to investigate whether morphological information can differentiate between subjects affected by diastolic dysfunction (patient group) and their age-matched controls (control group). The ventriculo-aortic region of 20 total participants (10 per group) were segmented from highresolution 3D magnetic resonance images, from the left ventricle to the descending aorta. Each geometry was divided into segments in correspondence of anatomical landmarks. The orientation of each segment was estimated by least-squares fitting of the respective centerline segment to a plane. Curvature and torsion of vessels' centerlines were automatically extracted, and aortic arch was characterized in terms of height and width.Tilt angle between subsequent best-fit planes in the left ventricle and ascending aorta regions, curvature and cross-sectional area in the descending aorta resulted significantly different between patient and control groups ( P -values < 0.05). Aortic volume ( P = 0.04) and aortic arch width ( P = 0.03) resulted significantly different between the two groups. The observed morphometric differences underlie differences in hemodynamics, by virtue of the influence of geometry on blood flow patterns.The present exploratory analysis does not determine if aortic geometric changes precede diastolic dysfunction, or vice versa. However, this study (1) underlines differences between healthy and diastolic dysfunction subjects, and (2) provides geometric parameters that might help to determine early aortic geometric alterations and potentially prevent evolution toward advanced diastolic dysfunction.

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Physiological Significance of Helical Flow in the Arterial System and its Potential Clinical Applications

Cited by 135 publications

References 107 publications

The influence of the aortic valve angle on the hemodynamic features of the thoracic aorta

The influence of the aortic valve angle on the hemodynamic features of the thoracic aorta

Numerical Assessment of Novel Helical/Spiral Grafts with Improved Hemodynamics for Distal Graft Anastomoses

Cardiovascular morphometry with high-resolution 3D magnetic resonance: First application to left ventricle diastolic dysfunction

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