Physiological Significance of Vascular Endothelial Growth Factor in Patients With Acute Forms of Coronary Artery Disease

Гавриленко, Т. И.; Ryzhkova, N.O.; Parkhomenko, O. M.; Dovgan, N.V.

doi:10.15407/fz65.05.033

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…Негативная регуляция в основном осуществляется протеолитическими фрагментами и большими протеинами, хорошо известными представителями которых являются ангиостатин и эндостатин [5]. Позитивная регуляция осуществляется семейством васкулоэндотелисального фактора роста и ангипоэтинами [3]. Одним из наиболее важных и сильных ангиогенных факторов является VEGF-A [40].…”

Section: физиологический ангиогенезunclassified

Angiogenesis: Literature Review

Vasilyev

Abushkin

et al. 2017

HSM

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The aim of this study was to examine theoretical aspects of angiogenesis. Methods. The analysis of current literature and studies devoted to angiogenesis process. Results. The healthy body controls angiogenesis through a balance of modulators, regulated by a strong interaction between growth factors and inhibitors, the imbalance of which can lead to disease. These diseases are caused by both excessive angiogenesis (cancer, diabetic eye disease, rheumatoid arthritis), and insufficient angiogenesis (coronary heart disease, stroke, delayed wound healing). Also some perspective treatment modalities for these patients are revealed. Conclusion. Over one billion people worldwide suffer from diseases associated with disturbed angiogenesis. Comprehensive study of angiogenesis provides better understanding of the formation of new vessels in the healthy body and of pathogenic mechanisms, which can help in prevention or treatment of some diseases.

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Section: физиологический ангиогенезunclassified

Angiogenesis: Literature Review

Vasilyev

Abushkin

et al. 2017

HSM

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Age-peculiarities of L-arginine, inosine and meldonium effects on the adult and old rat vascular wall reactivity

Sykalo,

Serebrovska,

Kuprash

et al. 2024

A&L

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Abstract. Cardiovascular diseases are most common in older people. The functional state of the vascular endothelium is important in the pathogenesis of cardiovascular diseases. Numerous physiologically active substances with different mechanisms of action can affect endothelial function L-arginine, inosine and meldonium caught our attention. Combination therapy is a promising direction in treating circulatory system diseases. This work aimed to establish the age-related characteristics of L-arginine, inosine and meldonium and their combination (Melarginine) on the vascular wall reactivity in adult and old rats to substantiate the occurrence of these cases in cardiology and geriatrics. Experiments were carried out on isolated norepinephrine (10-7 mol/l) segments of the thoracic aorta of adult (8-10 months) and old (21-23 months) outbred male rats. It was shown that the vasodilatory effect of L-arginine, inosine and meldonium and their combination (Melarginine) was insignificant. At the same time, the isolated vascular segment relaxation of old rats under the studied substances was significantly greater compared to adult animals. It should be noted that the vasodilatory effect of acetylcholine in old rats was significantly less than in adults. This indicates the practical endothelium preservation in adult animals and its damage in old ones. The greater sensitivity of the vascular wall of old rats to the action of L-arginine, inosine and meldonium and their combination Melarginine indicates their action is directed at restoring endothelial function in old animals. This suggests the feasibility of using Melarginine in geriatric practice for cardiovascular disease treatment in the future. _________________________________________________________________________________________ Keywords: vessel reactivity; ageing; L-arginine; inosine; meldonium; Melarginine

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Physiological Significance of Vascular Endothelial Growth Factor in Patients With Acute Forms of Coronary Artery Disease

Cited by 2 publications

References 21 publications

Angiogenesis: Literature Review

Angiogenesis: Literature Review

Age-peculiarities of L-arginine, inosine and meldonium effects on the adult and old rat vascular wall reactivity

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