Angiogenesis: Literature Review

I, Vasilyev; Vasilyev, Sergey A.; Abushkin, Ivan A.; Denis, Alain; Sudeykina, O; Lapin, V. O.; Romanova, O; Vasilyev, Yu.S.; Vasilyev, V.S.; Карпов, Ю. А.

doi:10.14529/hsm170104

Cited by 2 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Обсуждение Существующие данные свидетельствуют о том, что неоваскуляризация и адипогенез -это процессы, связанные во времени и пространстве, обладающие способностью взаимодействовать через паракринные сигнальные системы на протяжении всей жизни [11]. Активированные адипоциты продуцируют множество ангиогенных факторов, включая свободные жирные кислоты, гормоны, факторы роста и цитокины, такие как лептин, адипонектин, резистин, VEGF, HGF, IGF-1, ангиогенин, IL-6, TNF-α и ангиопоэтины [6,12,13].…”

Section: Discussionunclassified

“…Полученные нами данные согласуются с результатами исследований ряда зарубежных авторов [3,15,16]. Известно, что МК в условиях оксидативного стресса вызывает повышение активности β-клеток поджелудочной железы, которые увеличивают секрецию инсулина и поддерживают гомеостатический метаболизм глюкозы в течение определенного периода времени [11]. Это сопровождается гиперинсулинемией и является первым шагом в инициации выраженных углеводных нарушений при ожирении [15] и у больных подагрой [16].…”

Section: Discussionunclassified

“…Несмотря на уже известные механизмы влияния IGF-1 на процессы клеточного роста и дифференциации, в литературе описаны достаточно противоречивые данные участия изучаемого цитокина в регуляции углеводного обмена и функционировании сердечнососудистой системы у больных с ожирением [11,19,20]. С учетом того, что содержание ангиогенных факторов сосудистого роста у больных подагрой ранее не изучалось, мы проанализировали данные других авторов.…”

Section: Discussionunclassified

See 2 more Smart Citations

Clinical and pathogenetic significance of angiogenesis factors (VEGF-A, HGF, IGF-1) in the development of cardiometabolic disorders in gout patients having different obesity phenotypes

et al. 2021

View full text Add to dashboard Cite

Aim. To study such circulating angiogenesis factors as vascular endothelial growth factor (VEGF-A), hepatocyte growth factor (HGF), insulin-like growth factor (IGF-1), as well as the cytokine profile (IL-1β, TNF-α, IL-6, IL-8, IL-23) and their soluble receptors (SRp55 TNF-α, SR IL-6) in the blood serum of gout patients having various obesity phenotypes.Material and methods. The study included 112 male patients with intercritical gout. The patients were divided into 2 study groups: the 1st group consisted of 39 patients with a metabolically healthy obesity (MHO) phenotype and body mass index (BMI) ≥25 kg/m2; the 2nd group included 73 people having metabolically unhealthy obesity (MUO) with impaired immune status, hypertension (HTN) and class 1 abdominal obesity. The control group consisted of 25 metabolically healthy subjects with normal body weight. Serum concentration of uric acid, CRP, insulin, leptin, insulin resistance index (HOMA-IR), cytokine status, plasma levels of VEGF-A, HGF, IGF-1 were studied. To assess the left ventricular (LV) diastolic function, tissue Doppler imaging of the mitral annulus was used.Results. In the group of patients with MUO, an increase of pro-inflammatory cytokines (IL-1β, IL-6, IL-23, TNF-α, SRp55 TNF-α) was revealed, while the level of TNF-α and IL-1β exceeds the control values in 4,7 and 6,8 times, respectively (p <0,05), and in the group of patients with MHO, 1,4 and 1,6 times, respectively (p<0,05). Correlations between VEGF-A and TNF-α (r=0,59, p<0,0001), IL-6 (r=0,68, p<0,001), CRP (r=0,59, p<0,0001), serum uric acid level (r=0,47, p<0,0001), decrease in high-density lipoprotein cholesterol (HDL-C) (r=-0,28, p<0,05) and diastolic blood pressure (r=0,51, p<0,0001) were determined. The concentration of HGF and VEGF-A correlated with BMI (p<0,001). Associations of IGF-1 and HGF with hyperuricemia, carbohydrate metabolism and diastolic remodeling were established.Conclusion. The relationship between circulating levels of VEGF-A, HGF and IGF-1 with indicators of cytokine status, carbohydrate metabolism and Doppler imaging criteria for LV diastolic dysfunction allows to consider them as additional predictors of unfavorable cardiovascular risk.

show abstract

Section: Discussionunclassified

See 1 more Smart Citation

Clinical and pathogenetic significance of angiogenesis factors (VEGF-A, HGF, IGF-1) in the development of cardiometabolic disorders in gout patients having different obesity phenotypes

et al. 2021

View full text Add to dashboard Cite

show abstract

Priority choice of topical antibacterial drugs in the commonly accepted paradigm of acute rhinosinusitis treatment

Krivopalov,

Ryazantsev,

Turieva

et al. 2023

Medicinskij sovet

View full text Add to dashboard Cite

Introduction. In the complex therapy of acute rhinosinusitis, topical drugs with different mechanisms of action and influence on the main links in the pathogenesis of acute infectious lesions of the mucous membrane of the paranasal sinuses are widely used. Local drugs with antibacterial, as well as mucolytic and vasoconstrictor effects do not inhibit mucociliary clearance, have a convenient release form and ensure dosing accuracy with each use.Aim. Evaluation of the clinical effectiveness of the use in complex therapy of a topical antibiotic of the aminoglycoside group in combination with a drug having vasoconstrictive and mucolytic effects of domestic production in the treatment of acute bacterial rhinosinusitis.Materials and methods. The study involved 30 patients with a verified diagnosis of acute bacterial rhinosinusitis of moderate severity aged 18 to 68 years, who were divided into two groups. Patients of the first group (n = 15), in addition to complex treatment (antibacterial, antihistamine and unloading therapy, anti-inflammatory and puncture treatment), used a drug with a bactericidal effect from the group of aminoglycosides (Tramicent). Patients of the second group (n = 15) supplemented the same treatment with a drug with mucolytic and vasoconstrictive action (Rhinostein®). The effectiveness of therapy was evaluated based on the results of three visits to the doctor within two weeks.Results. The positive dynamics of the subjective and objective status of patients in both study groups was noted. By the 3rd visit (10–14 days), the severity of clinical manifestations in patients who used two drugs Tramicent and Rhinostein® as additional therapy was 2 times lower than at the first visit compared with the group of patients who used only Tramicent as additional therapy. The absence of complaints after treatment in the 2nd group was noted by 15% of the examined, in the 1st – 10%.Conclusions. Topical drug from the group of aminoglycosides containing the active substance framycetin sulfate (Tramicent) in the form of a spray is a safe and effective remedy in the complex therapy of bacterial rhinosinusitis, and its use in combination with the drug mucolytic and vasoconstrictive action (Rhinostein®) significantly reduces the duration of treatment and improves the quality of life of patients.

show abstract

Angiogenesis: Literature Review

Cited by 2 publications

References 13 publications

Clinical and pathogenetic significance of angiogenesis factors (VEGF-A, HGF, IGF-1) in the development of cardiometabolic disorders in gout patients having different obesity phenotypes

Clinical and pathogenetic significance of angiogenesis factors (VEGF-A, HGF, IGF-1) in the development of cardiometabolic disorders in gout patients having different obesity phenotypes

Priority choice of topical antibacterial drugs in the commonly accepted paradigm of acute rhinosinusitis treatment

Contact Info

Product

Resources

About