Jerusalem artichoke grows underground tubers that store fructans, primarily inulin, which are considered as prebiotics and functional dietary fibre with positive physiological benefits on human health. The aim of this study was to assess the yield and nutritional quality of Jerusalem artichoke tubers according to different cropping systems on dry sandy soils from Southern Romania. The experiments were carried out during 2018-2020 at the Research and Development Station for Plant Culture on Sands Dăbuleni, using a randomized complete block design with three replications. The experimental combined factors applied were fertilization with plants density (5×2). After the tubers were harvested, their quality was evaluated using standard methods. The results suggest that Jerusalem artichoke crop has minimal requirements for fertilization and tolerates very well high plants density without affecting significantly the yield and the nutritional features analysed, respectively the contents in total dry matter, soluble dry matter, inulin, soluble carbo-hydrates and C vitamin. A significant positive correlation was determined between the soluble dry matter and soluble carbohydrates content. The assessed biochemical compounds displayed high values in both fertilized and unfertilized conditions and in both densities, showing that Jerusalem artichoke is a perennial crop with multifunctional high growing potential in marginal terrains usually improper for the conventional crops.