Physiology of some actinomycete genera

Ensign, Jerald C.; Normand, Philippe; Burden, J.P.; Yallop, C.A.

doi:10.1016/0923-2508(93)90070-i

Cited by 14 publications

(11 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…# P \ 0.05, Student's t-test;n = 4-5 Cell Mol Neurobiol (2008) 28:971-979 975 et al 2000, plants (Nam et al 2001;Kazi et al 2003;Jana et al 2004), and possibly the chemical industry (Kisselev and Goldberg 2001). In brief, lactacysin and epoxomicin, which are naturally produced by actinomycetes, are found globally in soil and aquatic habitats of garden and farmland (Cross 1981;Ensign et al 1993). These microbes can infect root vegetables and potatoes causing scab formation (Cross 1981;Ensign et al 1993).…”

Section: Discussionmentioning

confidence: 98%

“…In brief, lactacysin and epoxomicin, which are naturally produced by actinomycetes, are found globally in soil and aquatic habitats of garden and farmland (Cross 1981;Ensign et al 1993). These microbes can infect root vegetables and potatoes causing scab formation (Cross 1981;Ensign et al 1993). Thus, it is noteworthy that potent proteasome inhibitors are found in rural areas and in well water, both of which have been shown to be associated with an increased risk of developing PD in epidemiological studies (Priyadarshi et al 2001).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Proteasome Inhibitor Does Not Enhance MPTP Neurotoxicity in Mice

et al. 2008

View full text Add to dashboard Cite

Dysfunction of the proteasome function is known to be a potential mechanism for dopaminergic neuron degeneration. Here, we investigated to determine whether systematic administration of proteasome inhibitor, carbobenzoxy-L-gamma-t-butyl-L-glutamyl-L-alanyl-L-leucinal (PSI), causes the increased susceptibility in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. PSI was injected into MPTP-treated mice over a period of 2 weeks. Thereafter, we evaluated the effect of PSI 2, 4, and 8 weeks after the cessation of treatment with PSI. In the present study with HPLC analysis, PSI did not enhance MPTP-induced dopaminergic neurotoxicity in mice. Our present study with Western blot analysis also demonstrated that the reduction of tyrosine hydroxylase (TH) and glial fibrillary acidic protein (GFAP) protein levels in MPTP-treated mice was more pronounced than that in MPTP + PSI-treated animals. These results suggest that proteasome inhibitor did not enhance MPTP neurotoxicity in mice. Our findings suggest that proteasome inhibition is not a reliable model for PD. Thus, our findings provide further valuable information for the pathogenesis of Parkinson's disease.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Proteasome Inhibitor Does Not Enhance MPTP Neurotoxicity in Mice

et al. 2008

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…In brief, lactacystin and epoxomicin, which are naturally produced by actinomycetes, are found globally in soil and aquatic habitats of garden and farmland (Cross 1981;Ensign et al 1993). These microbes can infect root vegetables and potatoes causing scab formation (Cross 1981;Ensign et al 1993). Thus, it is noteworthy that potent proteasome inhibitors are found in rural areas and in well water, both of which have been shown to be associated with an increased risk of developing PD in epidemiological studies (Priyadarshi et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Systemic Administration of Proteasome Inhibitor Protects Against MPTP Neurotoxicity in Mice

et al. 2009

View full text Add to dashboard Cite

Dysfunction of the proteasome has been suggested to contribute in the degeneration of nigrostriatal dopaminergic neurons. Here, we investigated to determine whether systematic administration of proteasome inhibitor, carbobenzoxy-L: -gamma-t-butyl-L: -glutamyl-L: -alanyl-L: -leucinal (PSI) protects against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice. Three administrations of MPTP at 1-h intervals to mice reduced significantly the concentration of dopamine, DOPAC (3,4-dihydroxyphenylacetic acid) and HVA (homovanillic acid) in the striatum after 5 days. In contrast, PSI (0.3 and 1.0 mg/kg) prevented a significant decrease in dopamine, DOPAC and HVA contents of the striatum 5 days after MPTP treatment. In our Western blot analysis study, PSI at a dose of 1.0 mg/kg prevented a significant decrease in TH (tyrosine hydroxylase) protein and a significant increase in glial fibrillary acidic protein 5 days after MPTP treatment. Furthermore, our immunohistochemical study showed that PSI at a dose of 1.0 mg/kg prevented a significant loss in TH immunopositive neurons in the striatum and substantia nigra 5 days after MPTP treatment. In contrast, PSI caused a significant increase in the number of intense ubiquitin immunopositive cells in the striatum and substantia nigra 5 days after MPTP treatment. These results indicate that proteasome inhibitors can protect against MPTP neurotoxicity in mice. The neuroprotective effect of PSI against dopaminergic cell damage may be mediated by the elevation of ubiquitination. Thus, our findings provide further valuable information for the pathogenesis of Parkinson's disease.

show abstract

“…Natural products have been the major source of numerous therapeutic agents [16, 25] producing more than a half of the drugs in use today in many therapeutic categories [7]. …”

Section: Introductionmentioning

confidence: 99%

The Occurrence of Bioactive Micromonosporae in Aquatic Habitats of the Sunshine Coast in Australia

2008

View full text Add to dashboard Cite

Abstract:Screening strategies based on the ecological knowledge of antibiotic producing microorganisms and their roles in the natural environment are being increasingly employed in the search for novel antibiotic agents. Micromonosporae are common inhabitants of aquatic habitats and have proved to be a continuing source of novel bioactive compounds including antibacterial and antitumor agents. The ecological distribution and frequency of bioactive micromonosporae in Sunshine Coast region aquatic habitats were studied through a range of selective isolation procedures designed to negatively select against the isolation of unwanted microbial taxa commonly associated with marine environments. It was revealed that bioactive compound producing species of micromonosporae were present in the aquatic habitats of the Sunshine Coast region in Australia.

show abstract

Physiology of some actinomycete genera

Cited by 14 publications

References 9 publications

Proteasome Inhibitor Does Not Enhance MPTP Neurotoxicity in Mice

Proteasome Inhibitor Does Not Enhance MPTP Neurotoxicity in Mice

Systemic Administration of Proteasome Inhibitor Protects Against MPTP Neurotoxicity in Mice

The Occurrence of Bioactive Micromonosporae in Aquatic Habitats of the Sunshine Coast in Australia

Contact Info

Product

Resources

About