Physiotherapy Intervention in Alzheimer's Disease: Systematic Review and Meta-Analysis

Abstract

The available data indicate that physiotherapy intervention may have benefits in AD. However, current data are not definitive; more carefully designed and conducted observational studies are needed to definitively establish that whether physiotherapy intervention can effectively alleviate symptoms of AD.

Experiences and needs of spouses of persons with young‐onset frontotemporal lobe dementia during the progression of the disease

“…Although dementia often occurs in older people, it can also develop before the age of 65 years . This group is defined as people with young‐onset dementia (YOD).…”

“…This group is defined as people with young‐onset dementia (YOD). The prevalence of dementia in persons age 64 and below in Norway with a population of 5 million people is estimated to be at least 4500 .…”

Ethical Considerations for Deep Brain Stimulation Trials in Patients with Early-Onset Alzheimer’s Disease

“…From this information, it is evident that five out of six DBS for AD studies recruited a total of 19 participants <65, all of which have at least mild cognitive impairment. This indicates an overrepresentation of EOAD in the study population (32.7%) given that [14]. Such overrepresentation of EOAD patients might not have been deliberately made by the authors and could have just been a result of better success in recruiting and enrolling younger patients due to their greater capacity to tolerate surgery [35] and provide consent [36].…”

“…Although the majority of people with AD are ≥65 [13], 5.5% of those affected have an onset of dementia before 65 [14] and thus are classified as having EOAD. The 65-year-old cut-off point has no biological significance and is mainly an indicative of social divide in terms of employment and retirement age [15].…”

Investigating Amyloid β toxicity in Drosophila melanogaste

“…Early-onset AD is genetic, with disease onset before the age of 65 and accounts for about 5% of all cases. Late-onset AD is sporadic, with disease onset after the age of 65 and accounts for around 95% of all cases [34]. To diagnose AD a complete medical assessment is needed.…”