Physostigmine emulsion: a new injectable controlled release delivery system

Benita, Simon; Friedman, Doron; Weinstock, Marta

doi:10.1016/0378-5173(86)90134-1

Cited by 41 publications

(16 citation statements)

References 17 publications

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“…Moreover, the incorporation of certain drugs in an emulsion formulation with phospholipids as sole emulsifier has been found to reduce stability and cause phase separation [5]. The combination of phospholipids and poloxamer as an emulsifying complex was found to increase emulsion stability, probably because of the formation of a complex interfacial film between poloxamer and the phospholipid molecules at the oilwater interface [6].…”

Section: Introductionmentioning

confidence: 99%

Stability of drug-carrier emulsions containing phosphatidylcholine mixtures

Trotta

Pattarino²,

Ignoni

2002

European Journal of Pharmaceutics and Biopharmaceutics

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Lipid emulsion particles containing 10% of medium chain triglycerides were prepared using 2% w/w of a mixture 1:1 w/w of purified soya phosphatidylcholine and 2-hexanoyl phosphatidylcholine as emulsifier mixture, for use as drug carriers. The mean droplet sizes of emulsions, prepared using an Ultra Turrax or a high-pressure homogenizer, were about 288 and 158 nm, respectively, compared with 380 and 268 nm for emulsions containing lecithin, or 325 and 240 nm for those containing 6-phosphatidylcholine. The stability of the emulsions, determined by monitoring the decrease of a lipophilic marker at a specified level within the emulsion, and observing coalescence over time, was also greatly increased using the emulsifier mixture. The emulsion stability did not notably change in the presence of a model destabilizing drug, indomethacin. The use of a second hydrophilic surfactant to adjust the packing properties of the lecithin at the oil-water interface provided an increase in the stability of lipid emulsions, and this may be of importance in the formulation of drug delivery systems. q

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Section: Introductionmentioning

confidence: 99%

Stability of drug-carrier emulsions containing phosphatidylcholine mixtures

Trotta

Pattarino²,

Ignoni

2002

European Journal of Pharmaceutics and Biopharmaceutics

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“…The charge on emulsion droplets was measured using the moving boundary electrophoresis technique. The shape of the electrophoresis cell and the manner of converting elec trophoretic mobility to zeta potential has been dis cussed in detail in previous works [7,8].…”

Section: Emulsion Evaluationmentioning

confidence: 99%

“…We have investigated innovative submi cron-medicated emulsions for several years, mainly as vehicles for lipophilic drugs [7][8][9], A possible use of these emulsions as vehicles for a lipophilic ophthalmic drug such as A8-tetrahydrocannabinol (A8-THC) appeared of interest.…”

Section: Introductionmentioning

confidence: 99%

A Submicron Emulsion as Ocular Vehicle for Delta-8-Tetrahydro cannabinol: Effect on Intraocular Pressure in Rabbits

et al. 1992

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Δ⁸-Tetrahydrocannabinol (Δ⁸-THC), a known antiglaucoma lipophilic drug, was incorporated in a submicron emulsion for ocular administration. The mean droplet size of the emulsion was 130 ± 41 nm, and no droplet was larger than 400 nm. No change in pH, particle size distribution or zeta potential was noted after sterilization by steam autoclaving or long-term storage over 9 months. An intense and long-lasting intraocular pressure (IOP)-depressant effect was observed after ocular application (50 µl) of the THC emulsion, 0.4% (w/w), to rabbits with ocular hypertension (chymotrypsin model). Lesser effects were observed in normotensive rabbits. No irritation effect of either the emulsion vehicle or THC emulsion on the rabbit eyes was detected. These results underline the promising properties of submicron emulsions as vehicles for lipophilic ophthalmic drugs. The mechanism by which the emulsion induced the marked Δ⁸-THC antiglaucoma effect remains unclear. However, the possible involvement of Δ⁸-THC systemic absorption in the hypotensive effect induced by the emulsion cannot be excluded and will be the subject of further investigation.

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“…the inability to provide sustained release of the drugs incorporated in oily droplets. [25,26] These colloidal vectors are prepared with lipids in solid state at room temperature, thus the drug mobility inside the nanoparticles is considerably decreased compared to liquid droplets. [27] SLNs can be prepared with multiple methods such as high shear homogenization and ultrasounds, [28] high pressure homogenization, [29,30] hot homogenization, [31] cold homogenization, [32] and emulsification/solvent evaporation.…”

Section: Introductionmentioning

confidence: 99%

Hot homogenization process optimization for fragrance encapsulation in solid lipid nanoparticles

Cortial

Vocanson

Loubry

et al. 2015

Flavour & Fragrance J

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Solid lipid nanoparticles (SLNs) loaded with perfume were prepared using a hot homogenization process coupled with ultrasounds. The objective was to develop a simple process adjustable to several kinds of lipids. The process comprised two steps: a pre-emulsion of the melted lipids in water followed by a size reduction by sonication, before cooling. The study of several formulation parameters showed that the size distribution of SLNs depended essentially on the sonication step, and especially on the ultrasounds power and time. Five types of SLNs loaded with perfume were produced, based on petrolatum, candelilla, shea butter, C10-18 triglycerides, and cetyl palmitate. The size distribution was below 200 nm with a narrow size distribution. Moreover, high encapsulation efficiency was obtained, at least 66.5% (±0.5) for petrolatum SLNs and 94.9% (±0.5) for cetyl palmitate SLNs and the loading % was comprised between 4.9% (±0.5) (petrolatum) and 7.0% (±0.5) (cetyl palmitate). A correlation between the partition coefficient of the molecules and the encapsulation efficiency was established for all lipids except cetyl palmitate. Cetyl palmitate, candelilla and petrolatum SLNs were stable for at least one month at 4°C and 25°C.

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Physostigmine emulsion: a new injectable controlled release delivery system

Cited by 41 publications

References 17 publications

Stability of drug-carrier emulsions containing phosphatidylcholine mixtures

Stability of drug-carrier emulsions containing phosphatidylcholine mixtures

A Submicron Emulsion as Ocular Vehicle for Delta-8-Tetrahydro cannabinol: Effect on Intraocular Pressure in Rabbits

Hot homogenization process optimization for fragrance encapsulation in solid lipid nanoparticles

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