Physostigmine Reversal Of Sedative Drugs

Rosenberg, Henry

doi:10.1001/jama.1974.03230470020010

Cited by 21 publications

(6 citation statements)

References 2 publications

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“…This analeptic property of physostigmine is probably an unspecific one, since the drug also antagonized central depression by neuroleptics (ROSENBERG, 1974;DI LIBERTI et aI., 1975;LARSON et aI., 1977). Moreover, physostigmine failed to reverse diazepam-induced sedation in patients undergoing dental extraction (GARBER et aI., 1980).…”

Section: Anticholinesterasesmentioning

confidence: 99%

General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

Haefely¹,

Pieri²,

Polc³

et al. 1981

Handbook of Experimental Pharmacology

114

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Section: Anticholinesterasesmentioning

confidence: 99%

General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

Haefely¹,

Pieri²,

Polc³

et al. 1981

Handbook of Experimental Pharmacology

114

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“…Interestingly, impaired mental status after droperidol is often ameliorated by physostigmine (17)(18)(19). In the present case, an acute neuroleptic-induced confusional state might be intensified by CNS anticholinergic effects produced by the intraoperative administration of atropine (20,21).…”

Section: Drug Rencfionsmentioning

confidence: 66%

Acute Postoperative Delirium and Extrapyramidal Signs in a Previously Healthy Parturient

Weinger

Swerdlow²,

Millar³

1988

Anesthesia & Analgesia

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“…bolus of physostigmine. The patients recover consciousness and appear normal but lapse into coma again within 30 min (Rosenberg, 1974).…”

Section: Discussionmentioning

confidence: 90%

“…dosing are in agreement with the dynamic effect of this drug observed in vivo. One clinical use of physostigmine is the treatment of coma induced by drugs with central anticholinergic activity (Duvoisin and Katz, 1968;Rosenberg, 1974;Nattel et al, 1979;Daunderer, 1980;Newton, 1975) or in the reversal of anesthesia (Rupreht, 1987). An almost immediate reversal of symptoms is reported following an i.v.…”

Section: Discussionmentioning

confidence: 99%

Brain regional distribution of physostigmine and its relation to cerebral blood flow following intravenous administration in rats

Scremin

Somani

et al. 1990

J of Neuroscience Research

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3H-labeled physostigmine (50 micrograms.kg-1) was administered intravenously to rats, and its concentration in brain tissue and spinal cord was assessed by quantitative autoradiography. Regional cerebral blood flow (rCBF) was measured with iodo-14C-antipyrine autoradiography in control rats and in animals injected i.v. with a dose of physostigmine similar to that used for the distribution studies. Tissue concentration of 3H-physostigmine was correlated with rCBF for 37 brain regions. A high degree of correlation was found at 0.5 min after drug injection, r (correlation coefficient) = 0.87. This association decreased at later times (5 min r = 0.73, 12 min r = 0.24). Structures with high cholinesterase activity (caudate-putamen, amygdala, hippocampus) showed greater retention of physostigmine over time. The highest initial physostigmine concentrations were found in regions lacking a blood-brain barrier (pineal bland, median eminence, choroid plexus) (range = 10.4-23.8 nCi/mg) and the lowest in white matter (corpus callosum, internal capsule, hippocampus commisure, spinal cord dorsal column) (range = 1.2-2.6 nCi/mg). Initial concentrations of the drug in the areas in which physostigmine induced vasodilatation (motor, sensory, temporal and occipital cortex, claustrum, and superior collicullus) were not different from concentrations in areas of comparable basal rCBF in which no such effect was observed. Variations in drug access to brain regions, then, do not explain the topographical variations of the cerebrovascular action of physostigmine.

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Physostigmine Reversal Of Sedative Drugs

Cited by 21 publications

References 2 publications

General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

Acute Postoperative Delirium and Extrapyramidal Signs in a Previously Healthy Parturient

Brain regional distribution of physostigmine and its relation to cerebral blood flow following intravenous administration in rats

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