Phytase supplementation increases bone mineral density, lean body mass and voluntary physical activity in rats fed a low-zinc diet☆

Scrimgeour, Angus G.; Marchitelli, Louis J.; Whicker, Jered S.; Song, Yang; Ho, Emily; Young, Andrew

doi:10.1016/j.jnutbio.2009.03.015

Cited by 10 publications

(7 citation statements)

References 41 publications

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“…Phytate is a major factor that accounts for why vegetarians or people in developing countries are at high risk of zinc deficiency. It has been demonstrated that dietary microbial phytase supplementation in animals fed zinc-deficient diets improves zinc status [13,52–55]. This study further shows that phytase supplementation improved zinc status and reversed the effects of marginal zinc depletion on DNA integrity in the prostate and suggests that phytase supplementation might be an effective intervention strategy to prevent zinc-deficiency-induced DNA damage in populations habitually consuming high-phytate, low-zinc diets.…”

Section: Discussionsupporting

confidence: 56%

“…In this study, we did not observe any difference in daily running distance between the MZD and the MZD + P or ZA groups until the end of the study. By week 6, the MZD group had less daily running distance than the MZD + P or ZA groups, which were not different from each other [13]. However, we would expect that the decreased exercise level would more likely to decrease, not increase, DNA lesions, as found in this study.…”

Section: Discussionmentioning

confidence: 50%

“…For the zinc and chronic exercise study, diets were prepared according to the LM-485 formulation provided by soy protein rather than casein (Research Diets) [13]. Zinc is provided as zinc carbonate in all diets.…”

Section: Methodsmentioning

confidence: 99%

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Marginal zinc deficiency increases oxidative DNA damage in the prostate after chronic exercise

Song¹,

Elias²,

Loban³

et al. 2010

Free Radical Biology and Medicine

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Approximately 12% of Americans do not consume the recommended level of zinc and could be at risk for marginal zinc deficiency. Zinc functions in antioxidant defense and DNA repair and could be important for prostate health. We hypothesized that marginal zinc deficiency sensitizes the prostate to oxidative stress and DNA damage. Rats were fed a zinc-adequate (ZA; 30 mg Zn/kg) or marginally zinc-deficient (MZD; 5–6 mg Zn/kg) diet for 6 weeks. MZD increased p53 and PARP expression but no change in 8-hydroxy-2′-deoxyguanosine levels was detected. To examine the susceptibility to exogenous oxidative stress, rats fed a ZA or MZD diet were assigned to exercising (EXE) or sedentary (SED) groups for 9 weeks. MZD or EXE alone did not affect oxidative DNA damage in the prostate; however, combined MZD + EXE increased DNA damage in the dorsolateral lobe. PARP and p53 expression was not further induced with MZD + EXE, suggesting that MZD interferes with DNA repair responses to stress. Finally, the addition of phytase to the MZD diet successfully restored zinc levels in the prostate and decreased DNA damage back to ZA levels. Overall, this study suggests that marginal zinc deficiency sensitizes the prostate to oxidative stress and demonstrates the importance of maintaining optimal zinc nutrition in physically active populations.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 50%

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Marginal zinc deficiency increases oxidative DNA damage in the prostate after chronic exercise

Song¹,

Elias²,

Loban³

et al. 2010

Free Radical Biology and Medicine

Self Cite

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show abstract

“…The microbial phytase supplementation significantly improved the digestibility of Ca, Mg, Mn, total P, phytate P and gross energy (Cheng and Hardy, 2002). Scrimgeour et al (2010) observed that supplementation of phytase to the diets of rats enhances Zn status to increase bone mineral density.…”

Section: Amelioration Of Nutritional Status Of Diets Of Nonruminantsmentioning

confidence: 93%

“…Scrimgeour et al. () observed that supplementation of phytase to the diets of rats enhances Zn status to increase bone mineral density.…”

Section: Amelioration Of Nutritional Status Of Diets Of Non‐ruminantsmentioning

confidence: 99%

Fungal phytases: characteristics and amelioration of nutritional quality and growth of non‐ruminants

Singh

Satyanarayana

2014

Animal Physiology Nutrition

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SummaryFungal phytases are histidine acid phosphatases, a subclass of acid phosphatases, which catalyse the hydrolysis of phytic acid resulting in the release of phosphate moieties and thus mitigate its antinutritional properties. The supplementation of feed with phytases increases the bioavailability of phosphorus and minerals in non-ruminant animals and reduces the phosphorus pollution due to phosphorus excretion in the areas of intensive livestock production. Although phytases are reported in plants, animals and micro-organisms, fungal sources are used extensively for the production of phytases on a commercial scale. Phytases have been produced by fungi in both solid-state fermentation (SSF) and submerged fermentation (SmF). The fungal phytases are high molecular weight proteins ranging from 35 to 500 kDa. They are optimally active within pH and temperature ranges between 4.5 and 6.0, and 45 and 70°C respectively. Phytate degradation leads to amelioration in the nutritional status of foods and feeds by improving the availability of minerals, phosphorus and proteins in non-ruminant animals and human beings and thus mitigates the environmental phosphorus pollution. Our article focuses on the role of fungal phytases in improving nutritional value of foods and feeds with concomitant increase in growth of non-ruminant animals and mitigating environmental phosphorus pollution.

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Zinc Intervention Strategies: Costs and Health Benefits

Scrimgeour¹,

Condlin²,

Otieno³

et al. 2010

Nutrients, Dietary Supplements, and Nutriceuticals

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Phytase supplementation increases bone mineral density, lean body mass and voluntary physical activity in rats fed a low-zinc diet☆

Cited by 10 publications

References 41 publications

Marginal zinc deficiency increases oxidative DNA damage in the prostate after chronic exercise

Marginal zinc deficiency increases oxidative DNA damage in the prostate after chronic exercise

Fungal phytases: characteristics and amelioration of nutritional quality and growth of non‐ruminants

Zinc Intervention Strategies: Costs and Health Benefits

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