Phytochemical and acute toxicity of ethanolic extract of Enantia chlorantha (oliv) stem bark in albino rats

Adebiyi, Olamide Elizabeth; Abatan, MO

doi:10.2478/intox-2013-0023

Cited by 37 publications

(32 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The forced swimming and tail suspension tests are well known models of depression sensitive to all classes of antidepressant including monoamine oxidase inhibitors, tricyclic antidepressants, and selective serotonin reuptake inhibitors [ 20 , 35 ]. Both tests are widely used screening methods for antidepressants in mice [ 20 , 21 ]. Carnosol, ursolic acid, and oleanolic acid exerted significant antidepressant effect as evidenced by the reduction of immobility time in both the tail suspension test and the forced swimming test.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

GABA‐A Receptor Modulation and Anticonvulsant, Anxiolytic, and Antidepressant Activities of Constituents from Artemisia indica Linn

Khan

Ahmad

Abdelhalim

et al. 2016

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Artemisia indica, also known as “Mugwort,” has been widely used in traditional medicines. However, few studies have investigated the effects of nonvolatile components of Artemisia indica on central nervous system's function. Fractionation of Artemisia indica led to the isolation of carnosol, ursolic acid, and oleanolic acid which were evaluated for their effects on GABA-A receptors in electrophysiological studies in Xenopus oocytes and were subsequently investigated in mouse models of acute toxicity, convulsions (pentylenetetrazole induced seizures), depression (tail suspension and forced swim tests), and anxiety (elevated plus maze and light/dark box paradigms). Carnosol, ursolic acid, and oleanolic acid were found to be positive modulators of α1β2γ2L GABA-A receptors and the modulation was antagonized by flumazenil. Carnosol, ursolic acid, and oleanolic acid were found to be devoid of any signs of acute toxicity (50–200 mg/kg) but elicited anticonvulsant, antidepressant, and anxiolytic activities. Thus carnosol, ursolic acid, and oleanolic acid demonstrated CNS activity in mouse models of anticonvulsant, antidepressant, and anxiolysis. The anxiolytic activity of all three compounds was ameliorated by flumazenil suggesting a mode of action via the benzodiazepine binding site of GABA-A receptors.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The acute toxicity study was conducted according to the modified method described by Adebiyi and Abatan [ 20 ]. Swiss albino mice (25–30 g) were randomly divided into ten groups ( n = 6).…”

Section: Methodsmentioning

confidence: 99%

GABA‐A Receptor Modulation and Anticonvulsant, Anxiolytic, and Antidepressant Activities of Constituents from Artemisia indica Linn

Khan

Ahmad

Abdelhalim

et al. 2016

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…The acute toxicity study was conducted according to the modified method described by Adebiyi & Abatan [19]. Swiss albino mice (25-30g) were randomly divided into ten groups (n=6).…”

Section: Acute Toxicitymentioning

confidence: 99%

Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis

et al. 2015

View full text Add to dashboard Cite

Purpose. Rosmarinus officinalis, traditionally known as rosemary, has been widely used in traditional medicines and has long been known as the herb of remembrance. However, few studies have investigated the effects of non-volatile components of rosemary on central nervous system function. Methods. Fractionation of R. officinalis led to the isolation of salvigenin, rosmanol and cirsimaritin, which were investigated in mouse models of acute toxicity, antinociception (tail immersion and hot plate tests), depression (tail suspension and forced swim tests) and anxiety (elevated plus maze and light/dark box paradigms). Results. Rosmanol, cirsimaritin and salvigenin were not found to exhibit any signs of acute toxicity (50-200 mg/kg), but elicited antinociceptive, antidepressant and anxiolytic activities. Conclusion. Rosmanol, cirsimaritin and salvigenin, all previously shown to have biphasic modulation of GABAA receptors, demonstrated CNS activity in mouse models of antinociception, antidepressant and anxiolysis. The anxiolytic activity of all three compounds was not ameliorated by flumazenil, but was inhibited by pentylenetetrazol, suggesting a mode of action via GABAA receptors at a site other than the high affinity benzodiazepine binding site. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

show abstract

“…Both tests are sensitive to quantifying the impact of all kind of antidepressant drugs (e.g. selective serotonin reuptake inhibitors, monoamine oxidase inhibitors and tricyclics) [38,39]. In our study, the 400-mg/kg extract dose led to greater reductions in immobility similar to those of the standard drug fluoxetine.…”

Section: Discussionmentioning

confidence: 54%

Possible neuropharmacological effects of Adenia trilobata (Roxb.) in the Swiss albino mice model

et al. 2020

View full text Add to dashboard Cite

Background Known colloquially as akandaphal in Bangladesh, Adenia trilobata has some traditional uses. Its leaves and stems are extracted with pure methanol (MEATL, MEATS) and fractioned by n-hexane (NFATL, NFATS). The in vivo anxiolytic activity was evaluated by elevated plus maze (EPM) testing and hole-board test (HBT), whilst the locomotor activity was examined using the open-field test (OFT) and hole-cross test (HCT) and the antidepressant activity was assessed with the forced swimming test (FST) and the tail suspension test (TST). Results Regarding the anxiolytic activity, the 400-mg/kg doses of MEATL, NFATL, MEATS and NFATS exhibited maximum percentages of entry into the open arm of 33.85%, 32.23%, 30.06% and 41.84%, respectively, compare with the diazepam (69.33%). During HBT, MEATL (400 mg/kg) and NFATL (400 mg/kg) demonstrated 51.67 ± 0.88 and 57.67 ± 3.18 instances of head-dipping relative to diazepam (64.33 ± 3.16), whilst the locomotor activity showed a dose-dependent reduction in square movements and number of hole crossings. During FST and TST, the NFATL (400 mg/kg) exhibited rates of 43.32% and 57.71% time spent immobile, whilst fluoxetine experienced rates of 54.79% and 55.74%. Conclusion Adenia trilobata could be a potential component for the treatment of neuropharmacological defects. Further study is required.

show abstract

Phytochemical and acute toxicity of ethanolic extract of Enantia chlorantha (oliv) stem bark in albino rats

Cited by 37 publications

References 20 publications

GABA‐A Receptor Modulation and Anticonvulsant, Anxiolytic, and Antidepressant Activities of Constituents from Artemisia indica Linn

GABA‐A Receptor Modulation and Anticonvulsant, Anxiolytic, and Antidepressant Activities of Constituents from Artemisia indica Linn

Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis

Possible neuropharmacological effects of Adenia trilobata (Roxb.) in the Swiss albino mice model

Contact Info

Product

Resources

About