Phytochemical and anti-MRSA constituents of Zanthoxylum nitidum

Zeng, Qi; Wang, Zhaojie; Chen, Song; Wang, Huan; Xie, Tian-Zhen; Xu, Xiang-Juan; Xiang, Mei-Ling; Chen, Yi-Chi; Luo, Xiao‐Dong

doi:10.1016/j.biopha.2022.112758

Cited by 34 publications

(6 citation statements)

References 28 publications

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“…Both compounds were first tested against methicillin-sensitive Staphylococcus aureus and showed higher activity against the resistant clinical isolates. Another two isoquinolines ( 4 and 5 ) were isolated from the roots of Zanthoxylum nitidum by Zeng et al (2022) . Compound 4 showed moderate and compound 5 showed low activity against MRSA, but both exhibited pronounced synergistic effects with ampicillin, which were attributed to the inhibition of the bacterial efflux pump.…”

Section: Resultsmentioning

confidence: 99%

Structure-dependent activity of plant natural products against methicillin-resistant Staphylococcus aureus

Cardenas

Çiçek

2023

Front. Microbiol.

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Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major causes for nosocomial infections and has been classified as “high priority pathogen” by the World Health Organization. Its ability to develop resistances has been a challenge for the last decades and is still a threat to health care systems, as strains with resistances to the so-called drugs of last resort have been discovered. Therefore, new antibiotics are urgently needed. Natural products are an important source for the development of new drugs, thereby mostly serving as lead compounds for further modification. In this review, the data on plant natural products with reported anti-MRSA activity until the end of 2022 is discussed, highlighting the most effective drugs with respect to their inhibitory concentrations as well as with regard to eventual synergistic effects with existing antibiotics. In the latter sense, the class of alkaloids must be mentioned, exhibiting additive or synergistic effects by inhibiting bacterial efflux pumps. With regard to the antibiotic activity, phloroglucinol derivatives certainly belong to the most promising compounds, revealing several candidates with remarkable effects, e.g., lupulone, ivesinol, rhodomyrtone, aspidinol, or hyperforin. Also, the class of terpenoids yielded noteworthy compounds, such as the sesquiterpene lactones parthenolide and lactopicrin as well as acetophenone sesquiterpenes and sphaerodiene type diterpenoids, respectively. In addition, pronounced effects were observed for the macrolide neurymenolide A and three flavonol dicoumaroylrhamnosides.

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Section: Resultsmentioning

confidence: 99%

Structure-dependent activity of plant natural products against methicillin-resistant Staphylococcus aureus

Cardenas

Çiçek

2023

Front. Microbiol.

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“…It was observed that one of the benzophenanthridine alkaloids increased ampicillin susceptibility in MRSA by inhibiting the microbial efflux pump. Invivo efficacy was demonstrated using a Murine model of skin infection, where the alkaloidampicillin combination significantly healed the MRSA-induced skin infection in mice (Zeng et al 2022).…”

Section: Zanthoxylum Nitidummentioning

confidence: 99%

Medicinal Remedies for the Treatment of Methicillin Resistant Staphylococcus Aureus

Saleem,

Chen

2023

Phytopharmacological Com.

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Antimicrobial resistance has led to the rise of formidable microbes like methicillin-resistant Staphylococcus aureus (MRSA). This infection can be acquired at the hospital and in a community, making the search for efficient treatment critical, given the rise in inefficacy of conventional treatments such as vancomycin. Phytocompounds can offer protection against these threats. They not only have the ability to kill MRSA but also enhance its susceptibility to previously ineffective antimicrobial agents. Plant-derived anti-MRSA agents can produce therapeutic effects comparable to some conventional treatments, and in some cases, they may even outperform an antibiotic. This article provided many examples of botanical compounds that have proven potent agents against MRSA in both in vitro and in vivo studies. These compounds achieve these effects by inhibiting the resistance mechanisms in MRSA, breaking down its defenses, making it vulnerable, and eventually killing it. Many of these compounds are inherently bactericidal; however, they may produce a synergistic response when combined with allopathic antibiotics. For example, plumbagin, from Plumbago zeylanica, not only disrupts MRSA cell wall morphology, eliciting cytoplasmic changes but also produces a synergistic effect with ciprofloxacin and piperacillin. Moreover, honokiol and magnolol glycosides, from Magnolia officinalis, reversed the quintessential resistance of MRSA by repressing genes, responsible for resistance development. The possibilities are indeed endless, but further research and financial investments are required for proper drug development.

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“…Moreover, the literature indicated that oxychelerythrine (1) has been reported from Z. nitidum, Z. schinifolium and Z. capense (Cabral et al, 2015); angoline (2) from Z. nitidum or Z. thomense (J. Liu et al, 2014;Simeray et al, 1985), while arnottianamide (3) was obtained from roots of Z. gilletii, Z. nitidum and Z. leprieurii (Adesina & Reisch, 1988;Zeng et al, 2022). This may suggest that benzo[c]phenanthridine alkaloids might be considered as markers compounds for the genus Zanthoxylum.…”

Section: Chemotaxonomic Significance Of the Studymentioning

confidence: 99%

Benzo[c]phenanthridine alkaloids and glycosylated flavonoids from the roots of Zanthoxylum gilletii (Rutaceae)

Dzouemo¹,

Happi²,

Happi³

et al. 2022

NRFHH

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The roots of Zanthoxylum gilletii have been chemically investigated and led to the isolation and characterization of nine compounds including three benzo[c]phenanthridine alkaloids oxychelerythrine (1), angoline (2) and arnottianamide (3); two glycosylated flavonoids hesperidin (4) and its analogue neohesperidin (5) along with four common specialized metabolites including sesamin (6), lupeol (7), β-sitosterol (8) and its derivative daucosterol (9). Their structures were established based on their recorded 1D and 2D-NMR data. Some compounds (1, 2, 3, 6 and 7) did not display a cytotoxic activity until the highest concentration of 200 μM against the human cell lines MCF-7 and A549. The chemotaxonomic relevance of this study has been discussed. To the best of our knowledge, except for the five compounds 3, 6-9, all the four others have been for the first time isolated from Z. gilletii (Rutaceae).

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Phytochemical and anti-MRSA constituents of Zanthoxylum nitidum

Cited by 34 publications

References 28 publications

Structure-dependent activity of plant natural products against methicillin-resistant Staphylococcus aureus

Structure-dependent activity of plant natural products against methicillin-resistant Staphylococcus aureus

Medicinal Remedies for the Treatment of Methicillin Resistant Staphylococcus Aureus

Benzo[<i>c</i>]phenanthridine alkaloids and glycosylated flavonoids from the roots of <i>Zanthoxylum gilletii</i> (Rutaceae)

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