Phytochemical and Antioxidant Activity of Avocado Leaf Extract (Persea americana Mill.)

Rahman, Nurdin; Dewi, Nikmah Utami; Bohari,

doi:10.3923/ajsr.2018.357.363

Cited by 10 publications

(9 citation statements)

References 23 publications

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“…Ascorbic acid has very high standard antioxidant activity, the percentage DPPH scavenging activity appeared to increase as concentration increased for both the standard and the other solvent extracts of consideration. The absorbance appeared to reduce as concentration increased and it correlated with what (Rahman et al, 2018) reported in a similar research. The varying of of IC50 value of P. Americana extract in ethanol and methanol is worthy of note.…”

Section: Gc-ms Analysis Of Bioactive Compoundssupporting

confidence: 89%

“…The varying of of IC50 value of P. Americana extract in ethanol and methanol is worthy of note. Compared to the IC50 values of Ascorbic acid which was 5mg/ml, methanolic extract had a lower IC50 value is 3.2mg/ml which according to previousliterature is a good one given that lower IC50 values indicate great antioxidant activity (Rahman et al, 2018). Ethanolic plant extract appeared to have the lowest IC50n value amongst the three of them 2.5 mg/ml which was lower that both the methanolic extract and the standard.…”

Section: Gc-ms Analysis Of Bioactive Compoundsmentioning

confidence: 67%

“…The extraction method of Persea americana (avocado) leaves using 95% HPLC grade ethanol and methanol as a universal solvent for refluxing is quite capable of dissolving polar compounds, so that multiple polar and non -polar compounds, such as certain bioactive elements contained in avocado leaves, can then be attracted to the solvent, although study has shown that ethanol is less effective in screening antioxidants (Rahman et al, 2018). Methanol in comparison to ethanol has proven to be a better solvent for extraction of bioactive and antioxidant but the use of ethanol is safer compared to methanol (Rahman et al, 2018). The Table 1 shows the total phenolic content of Persea Americana extracted by both 95% methanol and ethanol respectively.…”

Section: Total Phenols and Total Flavannoid Contentmentioning

confidence: 99%

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Persea americana Metanolik ve Etanolik Bitki Ekstraktlarının in vitro Biyolojik Aktivite ve Kimyasal Bileşiminin Karşılaştırmalı Çalışması

Kavaz¹,

Ogbonna²

2019

European Journal of Science and Technology

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The aim of this study was to evaluate and compare biological activity, chemical composition, antioxidant and antimicrobial activity of Persea Americana mill refluxed in various solvents, ethanol and methanol respectively. Persea Americana is a plant that is quite new to the turkish medicine and found its way to Turkey as it is little over 10 years old in use. It has been used to treat certain skin problems anddiahrea. The plant extraction was done with various solvents and comparison was done between the extracts produced by ethanol solvent and that of methanol solvent. Chemical constituents of the leaf extract were analyzed using techniques of gas chromatography/mass spectrometry (GC/MS). The methods employed for in vitro antimicrobial screening were the broth microdilution assay and Kirby bauer assay. The technique 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging was applied for antioxidant activity. The ethanol aqueous extract (EAE) IC50 value of 2,4 mg / mL and methanol aqueous extract (MAE) IC50 value was 2,51 mg/ml respectively. According to literature the lesser the IC50 value the more potent the molecule is in the DPPH assay, therefore the results of the IC50 for could be viewded as a powerful antioxidant thus it is highly potent. Scavenging activity for the MAE and EAE were analyzed. Scavenging/inhibition activity increases as concentration increases. The antibacterial activities of the various solvent extract were screened and compared against to Bacillus cereus, Escherichia coli, Staphylococcus Aureus and Salmonella typhrium. The aqueous extracts showed a favourable amount of microbial activity, especially on S. Aureus and E. coli. Persea Americana in both extract conditions showed strong antioxidant ability, strong antimicrobial activity and gave an impressive amount of chemical components which reveal the compounds responsible for its biological activities.

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Section: Gc-ms Analysis Of Bioactive Compoundssupporting

confidence: 89%

Section: Gc-ms Analysis Of Bioactive Compoundsmentioning

confidence: 67%

Section: Total Phenols and Total Flavannoid Contentmentioning

confidence: 99%

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Persea americana Metanolik ve Etanolik Bitki Ekstraktlarının in vitro Biyolojik Aktivite ve Kimyasal Bileşiminin Karşılaştırmalı Çalışması

Kavaz¹,

Ogbonna²

2019

European Journal of Science and Technology

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“…Phytochemical compounds contained in avocado leaf extract have a role as a protective agent for pancreatic cells. The phytochemical screening test shows these compounds in avocado leaf extract [23].…”

Section: Discussionmentioning

confidence: 99%

The Avocado (Persea americana Mill.) Leaf Extract on Streptozotocin-induced Pancreatic Cell Regeneration of White Rats (Rattus norvegicus)

Rahman

Tangkas

Sabang

et al. 2021

Open Access Maced J Med Sci

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Objectibe The rate of pancreatic cell regeneration after avocado leaf extract intervention in a diabetic animal model induced by streptozotocin was investigated in this study. Method: Experimental study was conducted on 18 male white rats as subjects, which were divided into 6 groups, 3 animals of each. Those were G1 (Feed + Streptozotocin + 10% Sucrose + 100 mg/kg b.w. of extract + 0.5% NaCMC), G2 (Feed + Streptozotocin + 10% Sucrose + 150 mg/kg b.w. of extract + 0.5% NaCMC), G3 (Feed + Streptozotocin + 10% Sucrose + 200 mg/kg b.w. of extract + 0.5% NaCMC), G4 (Feed + Streptozotocin + 10% sucrose + 0.5% Na-CMC), G5 (Feed + Streptozotocin + 10% sucrose + Glibenclamid + 0.5% Na-CMC), G6 (Normal healthy animal + Feed). Results: The pancreatic cells damage in animal diabetic model, G1 = 1.67 (moderate cell damage); G2 = 1.00 (mild cell damage); G3 = 0.33 (no damage); G4 = 3.00 (severe cell damage); G5 = 0.33 (no damage); G6 = 0.33 (no damage). Conclusion: The dose of 200 mg/kg b.w. of avocado leaf extract contributed the most significant recovery of pancreatic cell of diabetic animal induced with streptozotocin, equivalent to glibenclamide.

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“…It is a medium to large tree, 9 to 20 meters tall and characterized as an evergreen plant whose leaves are usually 7 to 41 cm in length and can be elliptic, oval or lanceolate in shape; although some varieties lose their leaves for a short time before flowering [8]. Avocado leaf extract is said to contain phytochemical substances such as flavonoids, saponins, tannins and steroids with a strong antioxidant that can be used to prevent and cope with oxidative stress [9]. Avocados are commercially valuable and are cultivated in tropical and Mediterranean climates throughout the world.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effect of Administering Avocado (Persea americana) Leaf Extract on Lead Acetate Toxicity in the Brain-cerebellum of Albino Rats

Isaac

2020

JOCAMR

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Aim: To investigate whether the aqueous extract of avocado leaves can be used in alternative medicine for the remediation or treatment of lead poisoning in the brain. Study Design: Pure Experiment, using animal models. Place and Duration of Study: Department of Anatomy, College of Medicine and Health Sciences, Abia State University, Uturu, Nigeria; between January 2019 and June 2019. Methodology: Twenty albino Wistar rats including both male and female, and weighing around 155 g were randomly assigned to four groups (designated as A,B,C and D), with each group consisting of five animals. While group A served as the control, group B was administered a daily dose of 500 mg/kg body weight of avocado leaf extract, group C received 150 mg/kg body weight per day of lead acetate, and group D was given 150 mg/kg body weight per day of lead acetate and immediately followed with 500 mg/kg body weight/day of the avocado leaf extract. Treatments were given once daily through the oral route using a syringe with attached micropipette tube for 15 days, while the animals had access to water and chow ad libitum. The rats were euthanized on the 16th day by cervical dislocation and the cranial cavity was carefully exposed in order to dissect the brain and to obtain tissue samples from the cerebellum, which were then prepared for microscopic examination using routine histological techniques, with hematoxylin and eosin (H&E) stains. Results: The findings showed the extract to be ameliorative by reducing histomorphological distortions of lead acetate toxicity in the brain, and thus caused moderate regeneration of the cerebellar tissue. Conclusion: The outcome of this research therefore indicates that the avocado leaf extract has medicinal potentials and could serve as an herbal remedy in the alternative treatment of lead poisoning.

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Phytochemical and Antioxidant Activity of Avocado Leaf Extract (Persea americana Mill.)

Cited by 10 publications

References 23 publications

Persea americana Metanolik ve Etanolik Bitki Ekstraktlarının in vitro Biyolojik Aktivite ve Kimyasal Bileşiminin Karşılaştırmalı Çalışması

Persea americana Metanolik ve Etanolik Bitki Ekstraktlarının in vitro Biyolojik Aktivite ve Kimyasal Bileşiminin Karşılaştırmalı Çalışması

The Avocado (Persea americana Mill.) Leaf Extract on Streptozotocin-induced Pancreatic Cell Regeneration of White Rats (Rattus norvegicus)

Ameliorative Effect of Administering Avocado (Persea americana) Leaf Extract on Lead Acetate Toxicity in the Brain-cerebellum of Albino Rats

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