Phytochemical and Antioxidant Properties of Stem Bark Extracts of Anthocleista nobilis

Ngwoke, Kenneth; Anusi, I. A.; Eze, Peter M.; Okezie, Ugochukwu Moses; Abba, Chika; Abonyi, Dominic O.

doi:10.9734/ejmp/2015/16107

Cited by 6 publications

(5 citation statements)

References 18 publications

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“…Phytochemical evaluation of the dried roots of Rhaphiostylis beninensis, dried seeds of Piper guineense and dried fruits of Xylopia aethiopica revealed the presence of avonoids, alkaloids, phenols, saponins, Phytate, Oxalate and tannins in varying concentrations (Table II). The presence of the above phytochemicals in Xylopia aethiopica is in consonance with earlier reports [14,15]. However, the relative compositions of alkaloids (2.23 ± 0.05), avonoids (4.04 ± 0.09) and saponins (0.28 ± 0.01) in the fruit extracts of X. aethiopica were higher than those of Uhegbu et al, (2011) [16]: alkaloids (1.49 ± 0.03), avonoids (0.22 ± 0.02) and saponins (0.18 ± 0.03).…”

Section: Phytochemical Constituents Of Thesupporting

confidence: 92%

Evaluation of the Mineral composition, Phytochemical and Proximate Constituents of three Culinary Spices in Nigeria: A Comparative Study

Evuen

Okolie

Apiamu

2022

Preprint

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A comparative assessment of the quantitative mineral composition, phytochemical and proximate constituents of Xylopia aethiopica (fruits), Piper guineense (seeds) and Rhaphiostylis beninensis (roots) was done using standard protocols. Mineral analysis of the culinary spices revealed significant differences (p < 0.05) in the Magnesium, Zinc, Iron, Selenium, Copper, Calcium, Manganese, Molybdenum, Potassium and Sodium contents of the spices. The respective concentrations of Iron and Selenium (16.03 ± 0.01, 0.25 ± 0.01 mg/L) in R. beninensis were the highest and lowest of all mineral elements evaluated in the three spices. Similarly, the carbohydrate and moisture contents (81.24 ± 0.25%, 0.71 ± 0.01%) of R. beninensis were the highest and lowest among all proximate parameters evaluated in the three spices. However, the Fibre contents of R. beninensis and P. guineense and the ash contents of P. guineense and X. aethiopica respectively, showed no significant differences (p > 0.05). Moreover, flavonoid and oxalate concentrations (4.04 ± 0.09%, 0.25 ± 0.04%) in X. aethiopica were the highest and lowest of phytochemicals in the three spices respectively. Nevertheless, there were no significant differences (p > 0.05) in the tannin content of P. guineense and X. aethiopica spices respectively. Similar trends were observed between the oxalate contents of R. beninensis and X. aethiopica, the phytate contents of R. beninensis and P. guineense and the saponin contents of the three spices respectively. These results indicate that the spices are notable sources of essential nutrients and phytochemicals. Therefore, they are possible candidates in the search for natural ingredients to formulate drugs and nutraceuticals by pharmaceutical industries.

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Section: Phytochemical Constituents Of Thesupporting

confidence: 92%

Evaluation of the Mineral composition, Phytochemical and Proximate Constituents of three Culinary Spices in Nigeria: A Comparative Study

Evuen

Okolie

Apiamu

2022

Preprint

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“…Anthocleista nobilis has been reported as having moderate anti-plasmodial effect in vivo, this activity has been attributed to the alkaloids in the plant (Sanon et al, 2013). Similarly, the antimalarial actions of Phyllanthus fraternus has been widely reported (Komlaga et al, 2016;Sittie et al, 1998;Malau et al, 2009). These findings are very significant as Adutwumwaa malamix, could serve as a potential alternative for the treatment of uncomplicated malaria in Ghana.…”

Section: Discussionmentioning

confidence: 96%

“…Traditionally, the bark of Vitex grandifolia Gurke is used to treat diarrhoea, bronchial complaints, rickets, sores and fever (Burkill, 1997). The Ezza people in Nigeria use the bark of Anthocleista nobilis as a worm expellant and as antimalarial remedy (Ngwoke et al, 2015). In Ghana, the plant extract of Phyllanthus fraternus G L Webster is reported to be a strongly diuretic and taken to allay spasms, such as griping in dysentery, it is also used as a laxative and to treat gonorrhoea and fever (Oudhia, 2008).…”

Section: Introductionmentioning

confidence: 99%

Clinical Evaluation of the Safety and Effectiveness of Adutwumwaa Malamix: A Polyherbal Product for the Treatment of Uncomplicated Malaria in Ghana

2017

J App Pharm Sci

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Antimalarial medications remain one of the major interventional tools for the global malaria control efforts. One of the most popular Ghanaian herbal antimalarial agent is the product sold under the trade name 'Adutwumwaa malamix'. This product is registered with the Food and Drugs Authority (FDA) of Ghana as treatment of uncomplicated malaria. In this study, the safety and effectiveness of the product 'Adutwumwaa malamix' for the treatment of uncomplicated malaria was clinically evaluated based on disease-oriented and patient-oriented evidence. A total of 42 subjects were recruited for the study. Complete cure was achieved for 35 (83.33%) of participants by day 7 of the study. Partial efficacy was also achieved for 7 (16.66%) of subjects. Patient reported symptoms such fever, chills and abdominal pains were also significantly improved by day 7 and absent by day 28. The safety parameters assessed did not show any clinically significant change among the study population during treatment. The outcome of the study indicates that the Ghanaian herbal antimalarial agent 'Adutwumwaa malamix' may be an effective herbal treatment for the management of uncomplicated malaria.

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“…Several species of Anthocleista (family Gentianaceae), including A. djalonensis, A. vogelii, A. nobilis, A. grandiflora, A. schweinfurthii, and A. liebrechtsiana, are commonly found in tropical African countries, including Nigeria, and have been used ethnomedicinally for the treatment of malarial fever and other disease conditions such as typhoid, hypertension, abdominal pain, hemorrhoids, syphilis, diabetes, and as a contraceptive and laxative. (3)(4)(5)(6) The stem, root bark, and leaves of A. djalonensis have traditionally been used to treat malaria in Nigeria, and scientific research has confirmed the plant's antimalarial activity. (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Isovitexin, the main phytoconstituent of Anthocleista djalonensis, may be responsible for the plant's antimalarial properties

Chika C. Abba,

Mildred C. Egwuatu,

Onyekachi Johnson

et al. 2024

Magna Sci. Adv. Biol. Pharm.

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Several studies have reported on the antimalarial properties of Anthoclestia djalonensis. This study was therefore conducted to validate this report and identify the phytocomponents of the plant that might be responsible for its antimalarial activity. The crude methanol extract of the plant was fractionated into ethyl acetate and n-butanol fractions using the liquid-liquid fractionation method. After a 5-day curative study, the plant's crude extract and fractions at 200 mg/kg showed varying levels of antimalarial properties, with the n-butanol fraction showing the highest parasite clearance (86.8%), followed by the crude extract (77.3%), and the ethyl acetate fraction (49.32%). HPLC analysis of the ethyl acetate and n-butanol fractions revealed isovitexin and its derivative as the plant's major phytoconstituents, and these compounds may be responsible for the plant's antimalarial property.

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Phytochemical and Antioxidant Properties of Stem Bark Extracts of Anthocleista nobilis

Cited by 6 publications

References 18 publications

Evaluation of the Mineral composition, Phytochemical and Proximate Constituents of three Culinary Spices in Nigeria: A Comparative Study

Evaluation of the Mineral composition, Phytochemical and Proximate Constituents of three Culinary Spices in Nigeria: A Comparative Study

Clinical Evaluation of the Safety and Effectiveness of Adutwumwaa Malamix: A Polyherbal Product for the Treatment of Uncomplicated Malaria in Ghana

Isovitexin, the main phytoconstituent of Anthocleista djalonensis, may be responsible for the plant's antimalarial properties

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