Alternative medicines or formulation based on natural sources are good option in diseases cure and prevention. Ficus carica is member of Moraceae family and its health management properties have been mentioned in religious books and traditional medicines. It holds various constituents including phenolic compounds, minerals and vitamins and such ingredient shows role in disease cure. Studies based on in vivo and in vitro reported that figs fruits, stem, leaves, and latex have health management effect through antioxidant, anti-inflammatory effects, antimicrobial, anticarcinogenic, and anti-inflammatory effects. Moreover, an inverse correlation between figs use and development of disease has been noticed. Despite its implications in disease management, little is known about their mechanism of action. In this review, efforts are made based on in vivo and in vitro studies to illuminate the role of F. carica leaves and fruits in the prevention of diseases.