Phytochemical and biological investigation on Artocarpus chaplasha Roxb

Abstract

The methanolic extract of the stem bark of Artocarpus chaplasha Roxb. (Family: Moraceae) was investigated for the isolation of pure compounds and determination of few biological activities. A mixture of two compounds cycloartenyl acetate and lupeol acetate were isolated from it. The crude methanol extract as well as its petroleum ether, chloroform, carbon tetrachloride and aqueous soluble fractions were studied for antioxidant, cytotoxic and antimicrobial activities. Among the different fractions, the aqueous soluble partitionate was found to have most potent antioxidant activity as compared to tertbutyl-1-hydroxytoluene. Antimicrobial screening of the different fractions was performed using the disc diffusion method. In these tests, the chloroform soluble fraction and carbon tetrachloride soluble fraction of methanolic extract exhibited moderate antimicrobial activity (range of zone of inhibition 8-12 mm). In brine shrimp lethality test, the petroleum ether soluble extract exhibited the highest level of cytotoxicity.

Phytochemical analysis and hypotensive activity of Ipomoea pes-caprae on blood pressure of normotensive rats

“…Besides hypertension, ethnopharmacological surveys describe several medicinal utilizations of this plant such as: analgesic, anti-inflammatory, diuretic, and healing cramps, ulcers, dermatitis caused by jellyfish venom, arthritis and rheumatism (Wasuwat 1970;Souza et al 2000;Lorenzi & Matos 2002;Pereda-Miranda et al 2005;Barni et al 2009). Phytochemical profile of Ipomoea pescaprae is characterized by the presence of glycosidic resins, coumarins, steroids, flavonoids and triterpenes (Krogh et al 1999;Pereda-Miranda et al 2005;Teramachi et al 2005;Escobedo-Martínez et al 2010;Yu et al 2011;Banerjee et al 2013;Sharmin et al 2013). Ipomoea flavonoids are mainly quercetin derivatives which are known for possessing anti-hypertensive activity (Krogh et al 1999;Loizzo et al 2008;Barni et al 2009;Larson et al 2010).…”