Phytochemical and Cytotoxic Investigations of Curcuma mangga Rhizomes

Malek, Sri Nurestri Abd; Lee, Guan Serm; Hong, Sok Lai; Yaacob, Hashim; Wahab, Norhanom Abdul; Weber, Jean Frederic; Shah, Syed Adnan Ali

doi:10.3390/molecules16064539

Cited by 73 publications

(56 citation statements)

References 15 publications

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“…It can be found in most tropical countries such as Indonesia, Malaysia, and Thailand [3]. C. mangga is locally known as "temu mangga" in Indonesia and is highly valued in folk medicine for its healing properties to treat stomach disorders, fever, and cancer-related diseases [4].…”

Section: Introductionmentioning

confidence: 99%

“…Phytochemical studies on C. mangga have resulted in the isolation of various compounds, including β-sitosterol, curcumin, (E)-labda-8(17),12-dien-15,16-dial, zerumin A (E)-15,16-bisnorlabda-8(17),11-dien-13-one, demethoxycurcumin and bisdemethoxycurcumin [4,5]. C. mangga has been reported to have analgesic and anti-inflammatory activities [6].…”

Section: Introductionmentioning

confidence: 99%

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Acute Toxicity Evaluation of Ethanol Extract of Curcuma Mangga Rhizome

Yuandani

Suwarso

2016

Asian J Pharm Clin Res

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Objective: Curcuma mangga is highly valued in traditional medicines. This study was carried out to evaluate the in vivo acute toxicity of C. mangga.Methods: Acute toxicity of ethanol extract of C. mangga rhizome was evaluated in mice. The extract at a single dose of 500, 1000, 2000 and 5000 mg/kg body weight (BW) were orally administered to the test animal. Signs of toxicity, BW and mortality were observed for 14 days. The macropathology and histopathology examination was also performed. Results:The highest dose administered (5000 mg/kg BW) did not produce mortality of the test animals. Hence, the lethal dose 50 of ethanol extract of C. mangga was estimated to be more than 5000 mg/kg. No sign of toxicity was observed except lethargy. All the organs displayed normal color and texture. Histopathological examination did not show any lesion except for highest dose. Conclusion:The results indicate the safety of ethanol extract of C. mangga rhizome to the animal tested. Therefore, this plant can be used as a safe and effective alternative medicine.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acute Toxicity Evaluation of Ethanol Extract of Curcuma Mangga Rhizome

Yuandani

Suwarso

2016

Asian J Pharm Clin Res

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“…mangga was found to contain various organic compounds including polyphenols, flavonoids, triterpenes, and sterols [6,7]. The plant was reported to have curcuminoid as its major components; these include curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC).…”

Section: Introductionmentioning

confidence: 99%

Curcuminoids Analysis in Curcuma Mangga Rhizomes

Yuandani

Yuliasmi

2018

Asian J Pharm Clin Res

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Objective: The current study was conducted to analyze the curcuminoid content in ethanol extract of Curcuma mangga. Methods:The constituent of ethanol extract of C. mangga was determined using ultra-performance liquid chromatography (UPLC). The diluted solutions of the extracts and the reference standards were analyzed separately by the reversed-phase UPLC method with mobile phase of acetonitrile: water (40:60) isocratically eluted for 30 min. Results:The chromatograms of the ethanol extract of C. mangga showed the presence of curcumin, bisdemethoxycurcumin, and demethoxycurcumin (DMC). Of all the curcuminoids content, DMC was the major component, corresponding to retention time at 9.96 min as compared to curcuminoid standard at 9.69 min. Conclusion:The results indicate that ethanol extract of C. mangga rhizomes contains DMC at the highest amount as compared to other curcuminoid compounds.

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“…For example, prior to the report by Abdul Malek et al [43], Alpinia mutica was previously reported to have inhibitory activity towards lipid oxidation [50] and anti-bacterial effects against Bacillus subtilis and methicillin-resistant Staphylococcus aureus (MRSA) [50] in addition to anti-platelet aggregation activities [51].…”

Section: Ht29 and Ccd-18comentioning

confidence: 99%

Studies of Malaysian Plants in Prevention and Treatment of Colorectal Cancer

Hashim¹,

Gill²,

Latimer³

et al. 2016

Colorectal Cancer - From Pathogenesis to Treatment

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Incidence rates vary 10-fold globally for colorectal cancer (CRC). Asia has lower rates than Western countries, but as the Western life-style becomes more prevalent in economically developing Asian countries, rates are increasing. Clinical therapy has improved over the last few decades, and national screening programmes are a proven and effective means of reducing mortality; chemoprevention through diet and life-style choices may provide additional value. Diet has strong associations with the aetiology of CRC, considerable epidemiological evidence exist that fruits and vegetables are associated with reduced risk of CRC. There is also extensive experimental evidence that phytochemicals from fruit and vegetables can modulate pathways of carcinogenesis. In this chapter, we consider Malaysia specifically, with its rich ethnopharmacological heritage and megabiodiversity; Malaysian natural compounds may be a source of potentially chemo-protective with relevance to CRC.

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Phytochemical and Cytotoxic Investigations of Curcuma mangga Rhizomes

Cited by 73 publications

References 15 publications

Acute Toxicity Evaluation of Ethanol Extract of Curcuma Mangga Rhizome

Acute Toxicity Evaluation of Ethanol Extract of Curcuma Mangga Rhizome

Curcuminoids Analysis in Curcuma Mangga Rhizomes

Studies of Malaysian Plants in Prevention and Treatment of Colorectal Cancer

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