Phytochemical and genotoxicity studies of Citrus reticulata aerial part in mice

Hassan, A.; Ahmed, Khadiga M.; Abu-Gabal, Nagat S; Mahrous, Karima F.; Shalaby, Nagwa M. M.

doi:10.4103/epj.epj_13_17

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…Hassan et al 64 investigate the protective effect of the ethanol extract of the aerial part of C. reticulata cultivated in Saudi Arabia against genotoxicity induced by benzo(a)pyrene (BaP) in mice using the comet assay. In the mice treated with BaP, there was a significant increase in the DNA fragmentation in the liver tissues of male mice and an increased rate of DNA damage in mice blood cells.…”

Section: Antigenotoxicity Effectsmentioning

confidence: 99%

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Review of the nutritional composition, medicinal, phytochemical and pharmacological properties of Citrus reticulata Blanco (Rutaceae)

2020

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Citrus reticulata Blanco is a moderately-sized fruit tree widely used as herbal medicine worldwide. The nutritional composition, medicinal uses, phytochemistry and pharmacological properties of C. reticulata were critically reviewed in the current study. The literature linked to C. reticulata properties was obtained from multiple internet sources including Elsevier, Google Scholar, SciFinder, Web of Science, Pubmed, BMC, Science Direct, and Scopus. Ethnopharmacological research identified antioxidants such as vitamin C, carotenoids and phenolic compounds, also a source of sugars, organic acids, amino acids, pectins, minerals and volatile organic compounds as components of C. reticulata. As a medicinal plant, C. reticulata is used for the treatment of dyspepsia, gastro-intestinal distension, cough with profuse phlegm, hiccup and vomiting. The crude extracts of C. reticulata fruits have depicted anti-inflammatory, anticholesterolemic, analgesic, antiasthmatic, antiscorbutic, antiseptic, antitussive, carminative, expectorant, stomachic. With more people becoming nutrition-conscious, there has been an increase in the demand for the use of citrus fruits and their by-products as traditional medicines for conventional healthcare in developing countries.

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Section: Antigenotoxicity Effectsmentioning

confidence: 99%

“…However, the liver and blood cells of the mice treated with ethanol extract demonstrated significant protection by inhibiting the rate of DNA damage. It was concluded that the aerial part of C. reticulata could be useful to reduce the genotoxicity induced by hazardous chemical agents 64 .…”

Section: Antigenotoxicity Effectsmentioning

confidence: 99%