Phytochemical and pharmacological potential of Acanthus ilicifolius

Singh, Dharya; Aeri, Vidhu

doi:10.4103/0975-7406.106557

Cited by 39 publications

(17 citation statements)

References 12 publications

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“…Astilbin, which is isolated from S. glabra , has significantly inhibitory effects on nitric oxide, TNF- α , and IL-6 production [ 28 ] through p65, ERK1/2, and JNK pathways [ 29 ]. In addition, anti-inflammatory, antiproliferative, and antioxidant activities have been well documented for S. corbularia [ 30 ], R. nasutus [ 31 , 32 ], A. ebracteatus [ 33 ], S. involute , S. collinsae [ 34 ], and Smilax sp. [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Antipsoriatic Effects of Wannachawee Recipe on Imiquimod‐Induced Psoriasis‐Like Dermatitis in BALB/c Mice

Takuathung

Wongnoppavich

Panthong

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Psoriasis is a common immune-mediated chronic inflammatory skin disease characterized by thick and erythema raised plaques with adherent silvery scales. T-cells are activated via the IL-23/Th17 axis which is involved in psoriasis pathogenesis. Conventional treatments of psoriasis have adverse events that influence patients' adherence. Wannachawee Recipe (WCR) is Thai traditional medicine that is known to be effective for psoriasis patients; however, preclinical evidence is still lacking. This study investigated the therapeutic potential of WCR on antiproliferant activity using imiquimod- (IMQ-) induced psoriasis-like dermatitis in a mouse model. Psoriasis-like dermatitis was induced on the shaved dorsal skin and right ear pinna of BALB/c mice by topical application of IMQ for 15 consecutive days after which WCR was administered to the mice by oral gavage for 10 days. Phenotypical observations, histopathological examinations, and ELISA of skin and blood samples were conducted. WCR significantly ameliorated development of IMQ-induced psoriasis-like dermatitis and reduced levels of Th17 cytokines (IL-17A, IL-22, and IL-23) in both serum and dorsal skin. Histopathological findings showed a decrease in epidermal thickness and inflammatory T-cell infiltration in the WCR-treated groups. The WCR has pharmacological actions which regulate Th17 related cytokines suggesting that it is a potential alternative therapeutic strategy for psoriasis.

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Section: Discussionmentioning

confidence: 99%

Antipsoriatic Effects of Wannachawee Recipe on Imiquimod‐Induced Psoriasis‐Like Dermatitis in BALB/c Mice

Takuathung

Wongnoppavich

Panthong

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Astilbin also downregulates T cell function by suppressing activated T cell migration and adhesion and stimulating negative regulatory interleukin 10 (IL-10) production [ 35 , 36 ]. In addition, anti-inflammatory, antiproliferative, and antioxidant activities have been well-documented for other components of WCR, including S. corbularia [ 37 ], R. nasutus [ 38 , 39 ], A. ebracteatus [ 40 ], S. involute , S. collinsae [ 41 ], and Smilax sp. [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Wannachawee Recipe with Antipsoriatic Activity on Suppressing Inflammatory Cytokine Production in HaCaT Human Keratinocytes

Takuathung

Wongnoppavich

Pitchakarn

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Psoriasis is a chronic inflammatory and immune-mediated skin disease. The pathogenesis involves T cells activation via the IL-23/Th17 axis. Conventional treatments of psoriasis have adverse events influencing patients' adherence. Wannachawee Recipe (WCR) has been effectively used as Thai folk remedy for psoriasis patients; however, preclinical evidence defining how WCR works is still lacking. This study defined mechanisms for its antiproliferation and anti-inflammatory effects in HaCaT cells. The cytotoxicity and antiproliferation results from SRB and CCK-8 assays showed that WCR inhibited the growth and viability of HaCaT cells in a concentration-dependent manner. The distribution of cell cycle phases determined by flow cytometry showed that WCR did not interrupt cell cycle progression. Interestingly, RT-qPCR revealed that WCR significantly decreased the mRNA expression of IL-1β, IL-6, IL-8, IL-17A, IL-22, IL-23, and TNF-α but induced IL-10 expression in TNF-α- and IFN-γ-induced HaCaT cells. At the protein level determined by ELISA, WCR significantly reduced the secretion of IL-17A, IL-22, and IL-23. The WCR at low concentrations was proved to possess anti-inflammatory effect without cytotoxicity and it did not interfere with cell cycle of keratinocytes. This is the first study to provide convincing evidence that WCR is a potential candidate for development of effective psoriasis therapies.

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“…Beberapa penelitian menyatakan bahwa senyawa bioaktif dari tumbuhan ini memiliki kemampuan untuk memerangi penyakit. Kandungan senyawa kimia dalam Acanthus ilicifolius berfungsi sebagai: neuralgia, analgesik, antiinflamasi, antioksidan, antifertilitas, hepatoprotektif, antitumor, antileukemia, antikanker, antimikroba, antivirus, antijamur juga dapat digunakan sebagai insektisida alami (Bose, 2008;Patra & Thatoi, 2011, 2011Singh & Aeri, 2013). Ekstrak kulit kayu Acanthus ilicifolius menggunakan pelarut air dapat digunakan sebagai antiseptik, obat alergi dingin, dan dermatitis di Thailand.…”

Section: Pendahuluanunclassified

Pemanfaatan ekstrak daun jeruju (<i>Acanthus ilicifolius</i>) sebagai bahan aktif krim anti acne

Nusaibah¹,

Pangestika

Herry

2021

Agrikan: J. Agro. Fish.

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Jeruju (Acanthus ilicifolius) is abundant in mangrove ecosystems in Indonesia and has high antibacterial, antioxidant and anti-inflammatory properties. In addition, the many uses of hazardous chemicals in anti-acne creams are the reason for the need of alternative natural ingredients for making anti-acne creams. So that in this study the use of jeruju leaf extract was added as an active ingredient of anti-acne cream. This research method was carried out by extracting the leaves of jeruju using ethanol solvent then made anti acne cream with extract concentrations of 1%, 5%, 10%, 15%. After that, sensory testing, TPC, antioxidant activity and antibacterial activity against acne-causing bacteria, namely Propionibacterium acne were carried out. The results of the antibacterial activity test of the four concentrations against P.acne produced inhibition zones with a range of values, namely 10.35-12.72 mm.. In testing the antioxidant activity, the best results were obtained at a concentration of 15% extract with an IC50 value of 98.80 ppm. From these results it can be concluded that jeruju is proven to inhibit P.acne bacteria, so that it has the potential to be used as an active ingredient in making anti-acne creams. Suggestions that can be given for further research are to make jeruju extract into a form that is more acceptable to consumers in terms of odor and color without reducing its content.

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Phytochemical and pharmacological potential of Acanthus ilicifolius

Cited by 39 publications

References 12 publications

Antipsoriatic Effects of Wannachawee Recipe on Imiquimod‐Induced Psoriasis‐Like Dermatitis in BALB/c Mice

Antipsoriatic Effects of Wannachawee Recipe on Imiquimod‐Induced Psoriasis‐Like Dermatitis in BALB/c Mice

Effects of Wannachawee Recipe with Antipsoriatic Activity on Suppressing Inflammatory Cytokine Production in HaCaT Human Keratinocytes

Pemanfaatan ekstrak daun jeruju (<i>Acanthus ilicifolius</i>) sebagai bahan aktif krim anti acne

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