Phytochemical and Pharmacological Review of Caesalpinia Bonducella

Abstract

Caesalpinia bonducella is classified under the family of Caesalpiniaceae. It is also known as C. bonducella Flem and C. crista Linn. The plant is found in the tropical and the subtropical parts of Asia. It is also found in Andaman, Nicobar islands and in all over India. The plant is a large prickly shrub. The branches are finely gray downy armed with hooked and hard prickles. Leaves, seeds, roots and bark of this plant are useful parts as a medicine. Caesalpinia bonducella (roxb.) shows antipyretic, anti-inflammatory, anthelmintic, antimalarial, antioxidant, antibacterial, antitumor and antidiabetic activities. The Phytochemical screening of C.bonducella shows the existence of different bioactive compounds like sterols,

Effect of Caesalpinia bonduc Polyphenol Extract on Alloxan-Induced Diabetic Rats in Attenuating Hyperglycemia by Upregulating Insulin Secretion and Inhibiting JNK Signaling Pathway

“…It is a thorny perennial shrub, native of Africa, South India, Sri Lanka, Malaysia, Burma, and Ceylon, particularly along the sea coast and up to 2500 ft. in hilly areas. Caesalpinia bonduc (C. bonduc) has a wide range of therapeutic effects like antioxidant, antiviral, antianaphylactic, antipyretic, antibacterial, antidiarrheal, and antiasthamatic potential [18,19]. These effects are due to the presence of phytoconstituents such as polyphenols, flavonoids, saponins, and terpenoids in different parts of C. bonduc such as leaves, roots, seeds, and bark.…”

Phytochemical Screening, Total Flavonoid and Total Phenolic Content and Antioxidant Activity of Different Parts of Caesalpinia bonduc (L.) Roxb

“…4 C. bonduc also distributed in other tropical and subtropical part of Asia, such as India, Shrilanka, Vietnam, China, Myanmar and Bangladesh. 5 In Indonesia, C. bonduc known as Bagore, Kalici, Tinglur, Areuy Matahiang. 6,7 C. bonduc is thorny perennial shrub with length reach of 15 m, stems are covered in curved spines.…”

The hypolipidemic activity of ethanolic extract of seed kernel of Caesalpinia bonducella fleming on serum lipids and atherogenesis in albino rats fed with high fat diet

“…31 Sitosterol, constituent of seed kernel of Caesalpinia bonducella, has been reported to possess hypocholesterolemic action by inhibiting the intestinal absorption of cholesterol and accelerating the catabolism of cholesterol to bile acid. 6,32 Hyperlipidemia caused by high fat diet leads to the generation of reactive oxygen species (ROS) by increased activation of NADPH oxidase, increased β oxidation of free fatty acid in mitochondria, increased NF-κβ signalling and dysregulated production of adipocytokinins. 33 This enhanced production of ROS leads to oxidative stress which in turn contributes to vascular changes, endothelial dysfunction, thrombosis and atherosclerosis.…”

“…5 The plant has been reported to possess antidiabetic and antihyperlipidemic, abortifacient, antioxidant, analgesic, antiinflammatory, antifilarial, anticonvulsive, antibacterial, antidiarrhoel, antimalarial, antipyretic, antifungal, antitumor, antiulcer, antipsoriatic, immunomodulatory, anticataract, anthelmintic and anticancer activities. 6 Literature reviews have indicated that although the antihyperlipidemic potential of the seed extract of this plant on diabetes-induced hyperlipidemia have been documented, no studies of the seed kernel extract of the plant on high fat diet-induced hyperlipidemia has been conducted so far. As such, the present study was aimed at evaluating the action of ethanolic extract of seed kernel of Caesalpinia bonducella Fleming on serum lipids and atherogenesis in albino rats fed with high fat diet.…”